Loss of Bardet-Biedl syndrome proteins causes defects in peripheral sensory innervation and function

Reception and interpretation of environmental stimuli is critical for the survival of all organisms. Here, we show that the ablation of BBS1 and BBS4, two genes mutated in Bardet-Biedl syndrome and that encode proteins that localize near the centrioles of sensory neurons, leads to alterations of s.c...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (44), p.17524-17529
Hauptverfasser: Tan, Perciliz L, Barr, Travis, Inglis, Peter N, Mitsuma, Norimasa, Huang, Susan M, Garcia-Gonzalez, Miguel A, Bradley, Brian A, Coforio, Stephanie, Albrecht, Phillip J, Watnick, Terry, Germino, Gregory G, Beales, Philip L, Caterina, Michael J, Leroux, Michel R, Rice, Frank L, Katsanis, Nicholas
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Sprache:eng
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