1H‐MR Spectroscopy Indicates Severity Markers in Temporal Lobe Epilepsy: Correlations between Metabolic Alterations, Seizures, and Epileptic Discharges in EEG
Purpose: In this study, hippocampal metabolite alterations in 1H‐MR spectroscopy (1H‐MRS) were correlated to the findings of intensive video‐EEG monitoring and duration of seizure symptoms in patients with temporal lobe epilepsy (TLE). Methods: The 14 patients with mesial TLE and no pathological fin...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2007-02, Vol.48 (2), p.263-269 |
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| creator | Hammen, Thilo Schwarz, Michael Doelken, Marc Kerling, Frank Engelhorn, Tobias Stadlbauer, Andreas Ganslandt, Oliver Nimsky, Christopher Doerfler, Arnd Stefan, Hermann |
| description | Purpose: In this study, hippocampal metabolite alterations in 1H‐MR spectroscopy (1H‐MRS) were correlated to the findings of intensive video‐EEG monitoring and duration of seizure symptoms in patients with temporal lobe epilepsy (TLE).
Methods: The 14 patients with mesial TLE and no pathological findings in imaging were investigated by 1H‐MRS. Seizures were analyzed by: number of clinical seizures in 24 h, exact duration of clinical symptoms in 24 h, frequency of interictal epileptiform discharges (IEDs) and ictal activity, duration of ictal activity, and IEDs occurring within 24 h in intensive EEG monitoring. Pearson Correlation Coefficient (PCC) was calculated between spectral metabolite alterations and the parameters mentioned above.
Results: In the analysis, a negative correlation was found between total (t) NAA values and degree of IEDs in EEG (p = 0.04); a positive correlation was found between Cr levels and duration of seizure symptoms registered by video monitoring (p = 0.01).
Conclusions: Our study shows that, in some patients, 1H‐MRS is able to refer the severity of TLE. The degree of tNAA reduction in 1H‐MRS, probably indicating neuronal dysfunction, is associated with interictal spiking in intensive EEG monitoring. Duration of seizure symptoms associated with increased Cr peaks probably reflects increased gliosis. |
| doi_str_mv | 10.1111/j.1528-1167.2006.00856.x |
| format | Article |
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Methods: The 14 patients with mesial TLE and no pathological findings in imaging were investigated by 1H‐MRS. Seizures were analyzed by: number of clinical seizures in 24 h, exact duration of clinical symptoms in 24 h, frequency of interictal epileptiform discharges (IEDs) and ictal activity, duration of ictal activity, and IEDs occurring within 24 h in intensive EEG monitoring. Pearson Correlation Coefficient (PCC) was calculated between spectral metabolite alterations and the parameters mentioned above.
Results: In the analysis, a negative correlation was found between total (t) NAA values and degree of IEDs in EEG (p = 0.04); a positive correlation was found between Cr levels and duration of seizure symptoms registered by video monitoring (p = 0.01).
Conclusions: Our study shows that, in some patients, 1H‐MRS is able to refer the severity of TLE. The degree of tNAA reduction in 1H‐MRS, probably indicating neuronal dysfunction, is associated with interictal spiking in intensive EEG monitoring. Duration of seizure symptoms associated with increased Cr peaks probably reflects increased gliosis.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2006.00856.x</identifier><identifier>PMID: 17295619</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>1H‐MR Spectroscopy ; Adult ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Biological and medical sciences ; Biomarkers - metabolism ; Brain Mapping ; Choline - metabolism ; Creatine - metabolism ; Dipeptides - metabolism ; Electrodiagnosis. Electric activity recording ; Electroencephalography - statistics & numerical data ; Epilepsy, Temporal Lobe - diagnosis ; Epilepsy, Temporal Lobe - metabolism ; Epilepsy, Temporal Lobe - physiopathology ; Epileptic discharges in EEG ; Female ; Functional Laterality ; Glutamine - metabolism ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampus - metabolism ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Spectroscopy - statistics & numerical data ; Male ; Medical sciences ; Metabolic alterations ; Monitoring, Physiologic ; Nervous system ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Pharmacology. Drug treatments ; Seizures ; Seizures - diagnosis ; Seizures - metabolism ; Severity of Illness Index ; Temporal Lobe - metabolism ; Temporal Lobe - physiopathology ; Temporal lobe epilepsy ; Videotape Recording</subject><ispartof>Epilepsia (Copenhagen), 2007-02, Vol.48 (2), p.263-269</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2006.00856.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2006.00856.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18547939$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17295619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammen, Thilo</creatorcontrib><creatorcontrib>Schwarz, Michael</creatorcontrib><creatorcontrib>Doelken, Marc</creatorcontrib><creatorcontrib>Kerling, Frank</creatorcontrib><creatorcontrib>Engelhorn, Tobias</creatorcontrib><creatorcontrib>Stadlbauer, Andreas</creatorcontrib><creatorcontrib>Ganslandt, Oliver</creatorcontrib><creatorcontrib>Nimsky, Christopher</creatorcontrib><creatorcontrib>Doerfler, Arnd</creatorcontrib><creatorcontrib>Stefan, Hermann</creatorcontrib><title>1H‐MR Spectroscopy Indicates Severity Markers in Temporal Lobe Epilepsy: Correlations between Metabolic Alterations, Seizures, and Epileptic Discharges in EEG</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Purpose: In this study, hippocampal metabolite alterations in 1H‐MR spectroscopy (1H‐MRS) were correlated to the findings of intensive video‐EEG monitoring and duration of seizure symptoms in patients with temporal lobe epilepsy (TLE).
Methods: The 14 patients with mesial TLE and no pathological findings in imaging were investigated by 1H‐MRS. Seizures were analyzed by: number of clinical seizures in 24 h, exact duration of clinical symptoms in 24 h, frequency of interictal epileptiform discharges (IEDs) and ictal activity, duration of ictal activity, and IEDs occurring within 24 h in intensive EEG monitoring. Pearson Correlation Coefficient (PCC) was calculated between spectral metabolite alterations and the parameters mentioned above.
Results: In the analysis, a negative correlation was found between total (t) NAA values and degree of IEDs in EEG (p = 0.04); a positive correlation was found between Cr levels and duration of seizure symptoms registered by video monitoring (p = 0.01).
Conclusions: Our study shows that, in some patients, 1H‐MRS is able to refer the severity of TLE. The degree of tNAA reduction in 1H‐MRS, probably indicating neuronal dysfunction, is associated with interictal spiking in intensive EEG monitoring. Duration of seizure symptoms associated with increased Cr peaks probably reflects increased gliosis.</description><subject>1H‐MR Spectroscopy</subject><subject>Adult</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Brain Mapping</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Dipeptides - metabolism</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Electroencephalography - statistics & numerical data</subject><subject>Epilepsy, Temporal Lobe - diagnosis</subject><subject>Epilepsy, Temporal Lobe - metabolism</subject><subject>Epilepsy, Temporal Lobe - physiopathology</subject><subject>Epileptic discharges in EEG</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Glutamine - metabolism</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Spectroscopy - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic alterations</subject><subject>Monitoring, Physiologic</subject><subject>Nervous system</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Seizures</subject><subject>Seizures - diagnosis</subject><subject>Seizures - metabolism</subject><subject>Severity of Illness Index</subject><subject>Temporal Lobe - metabolism</subject><subject>Temporal Lobe - physiopathology</subject><subject>Temporal lobe epilepsy</subject><subject>Videotape Recording</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkd9u0zAUhy0EYmXwCsg3cEXCcRInMeJmKmGr1ArExrV1nJ6AS5pkdspWrngEHoFn40lw1sJ84yP9Pv3852OMC4hFWK83sZBJGQmRF3ECkMcApczj2wds9j94yGYAIo2ULOGEPfF-AwBFXqSP2YkoEiVzoWbst7j48_PX6hO_HKgeXe_rftjzRbe2NY7k-SV9J2fHPV-h-0bOc9vxK9oOvcOWL3tDvBpsS4Pfv-Hz3jlqcbR957mh8Yao4ysa0fStrflZO5I7pK9Cr_2xcxQm7NbHjjFA76yvv6L7QncnVdX5U_aowdbTs-N-yj6_r67mF9Hyw_lifraMhkSUeVTKAvKkSRVkBQJQYZREarAwQAlKpUDlIRGosMxMtm6MkIYAFSWQGUjSU_by0Du4_npHftTbcBVqW-yo33kdMJnKRAXw-RHcmS2t9eDsFt1e__vTALw4AuhrbBuHXW39PVfKrFDpxL09cDfh8fv7HPTkWG_0pFJPKvXkWN851re6-rgIQ_oXULmcFg</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Hammen, Thilo</creator><creator>Schwarz, Michael</creator><creator>Doelken, Marc</creator><creator>Kerling, Frank</creator><creator>Engelhorn, Tobias</creator><creator>Stadlbauer, Andreas</creator><creator>Ganslandt, Oliver</creator><creator>Nimsky, Christopher</creator><creator>Doerfler, Arnd</creator><creator>Stefan, Hermann</creator><general>Blackwell Publishing Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope></search><sort><creationdate>200702</creationdate><title>1H‐MR Spectroscopy Indicates Severity Markers in Temporal Lobe Epilepsy: Correlations between Metabolic Alterations, Seizures, and Epileptic Discharges in EEG</title><author>Hammen, Thilo ; Schwarz, Michael ; Doelken, Marc ; Kerling, Frank ; Engelhorn, Tobias ; Stadlbauer, Andreas ; Ganslandt, Oliver ; Nimsky, Christopher ; Doerfler, Arnd ; Stefan, Hermann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2186-857062f39047a00e7b95aefa7b0e2a59909647a1a9a84b4dfb15be0a9e204b023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>1H‐MR Spectroscopy</topic><topic>Adult</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Brain Mapping</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Dipeptides - metabolism</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Electroencephalography - statistics & numerical data</topic><topic>Epilepsy, Temporal Lobe - diagnosis</topic><topic>Epilepsy, Temporal Lobe - metabolism</topic><topic>Epilepsy, Temporal Lobe - physiopathology</topic><topic>Epileptic discharges in EEG</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Glutamine - metabolism</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Spectroscopy - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic alterations</topic><topic>Monitoring, Physiologic</topic><topic>Nervous system</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Seizures</topic><topic>Seizures - diagnosis</topic><topic>Seizures - metabolism</topic><topic>Severity of Illness Index</topic><topic>Temporal Lobe - metabolism</topic><topic>Temporal Lobe - physiopathology</topic><topic>Temporal lobe epilepsy</topic><topic>Videotape Recording</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammen, Thilo</creatorcontrib><creatorcontrib>Schwarz, Michael</creatorcontrib><creatorcontrib>Doelken, Marc</creatorcontrib><creatorcontrib>Kerling, Frank</creatorcontrib><creatorcontrib>Engelhorn, Tobias</creatorcontrib><creatorcontrib>Stadlbauer, Andreas</creatorcontrib><creatorcontrib>Ganslandt, Oliver</creatorcontrib><creatorcontrib>Nimsky, Christopher</creatorcontrib><creatorcontrib>Doerfler, Arnd</creatorcontrib><creatorcontrib>Stefan, Hermann</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammen, Thilo</au><au>Schwarz, Michael</au><au>Doelken, Marc</au><au>Kerling, Frank</au><au>Engelhorn, Tobias</au><au>Stadlbauer, Andreas</au><au>Ganslandt, Oliver</au><au>Nimsky, Christopher</au><au>Doerfler, Arnd</au><au>Stefan, Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1H‐MR Spectroscopy Indicates Severity Markers in Temporal Lobe Epilepsy: Correlations between Metabolic Alterations, Seizures, and Epileptic Discharges in EEG</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2007-02</date><risdate>2007</risdate><volume>48</volume><issue>2</issue><spage>263</spage><epage>269</epage><pages>263-269</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Purpose: In this study, hippocampal metabolite alterations in 1H‐MR spectroscopy (1H‐MRS) were correlated to the findings of intensive video‐EEG monitoring and duration of seizure symptoms in patients with temporal lobe epilepsy (TLE).
Methods: The 14 patients with mesial TLE and no pathological findings in imaging were investigated by 1H‐MRS. Seizures were analyzed by: number of clinical seizures in 24 h, exact duration of clinical symptoms in 24 h, frequency of interictal epileptiform discharges (IEDs) and ictal activity, duration of ictal activity, and IEDs occurring within 24 h in intensive EEG monitoring. Pearson Correlation Coefficient (PCC) was calculated between spectral metabolite alterations and the parameters mentioned above.
Results: In the analysis, a negative correlation was found between total (t) NAA values and degree of IEDs in EEG (p = 0.04); a positive correlation was found between Cr levels and duration of seizure symptoms registered by video monitoring (p = 0.01).
Conclusions: Our study shows that, in some patients, 1H‐MRS is able to refer the severity of TLE. The degree of tNAA reduction in 1H‐MRS, probably indicating neuronal dysfunction, is associated with interictal spiking in intensive EEG monitoring. Duration of seizure symptoms associated with increased Cr peaks probably reflects increased gliosis.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17295619</pmid><doi>10.1111/j.1528-1167.2006.00856.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1H‐MR Spectroscopy Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Biomarkers - metabolism Brain Mapping Choline - metabolism Creatine - metabolism Dipeptides - metabolism Electrodiagnosis. Electric activity recording Electroencephalography - statistics & numerical data Epilepsy, Temporal Lobe - diagnosis Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - physiopathology Epileptic discharges in EEG Female Functional Laterality Glutamine - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Spectroscopy - statistics & numerical data Male Medical sciences Metabolic alterations Monitoring, Physiologic Nervous system Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Seizures Seizures - diagnosis Seizures - metabolism Severity of Illness Index Temporal Lobe - metabolism Temporal Lobe - physiopathology Temporal lobe epilepsy Videotape Recording |
| title | 1H‐MR Spectroscopy Indicates Severity Markers in Temporal Lobe Epilepsy: Correlations between Metabolic Alterations, Seizures, and Epileptic Discharges in EEG |
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