Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice

ObjectiveNardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular space and a transcriptional coregulator in the nucleus. In this study, we investigated its functional role in exocrine pancreatic deve...

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Veröffentlicht in:	Gut 2019-05, Vol.68 (5), p.882-892
Hauptverfasser:	Ikuta, Kozo, Fukuda, Akihisa, Ogawa, Satoshi, Masuo, Kenji, Goto, Norihiro, Hiramatsu, Yukiko, Tsuda, Motoyuki, Kimura, Yoshito, Matsumoto, Yoshihide, Kimura, Yuto, Maruno, Takahisa, Kanda, Keitaro, Nishi, Kiyoto, Takaori, Kyoichi, Uemoto, Shinji, Takaishi, Shigeo, Chiba, Tsutomu, Nishi, Eiichiro, Seno, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar cells Adenocarcinoma Animals Apoptosis Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - prevention & control Chemokines Clonal deletion Cre recombinase Diabetes Disease Models, Animal DNA microarrays Epidermal growth factor Gastroenterology Gene expression Homeostasis Immunohistochemistry Inflammation Kinases Localization Metalloendopeptidases - physiology Mice Mutation Pancreas Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Neoplasms - prevention & control Pancreatitis Pancreatitis - metabolism Pancreatitis - pathology Pancreatitis - prevention & control Peptidase Transcription Tumor necrosis factor-TNF Tumors
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