Design, Synthesis, and Evaluation of Novel p‑(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G‑Quadruplex

The human proto-oncogene neuroblastoma RAS (NRAS) contains a guanine-rich sequence in the 5′-untranslated regions (5′-UTR) of the mRNA that could form an RNA G-quadruplex structure. This structure acts as a repressor for NRAS translation and could be a potential target for anticancer drugs. Our prev...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-08, Vol.61 (15), p.6629-6646
Hauptverfasser:	Peng, Wang, Sun, Zhi-Yin, Zhang, Qi, Cheng, Sui-Qi, Wang, Shi-Ke, Wang, Xiao-Na, Kuang, Guo-Tao, Su, Xiao-Xuan, Tan, Jia-Heng, Huang, Zhi-Shu, Ou, Tian-Miao
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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