Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy
The aim of the study is examine the impact of non-obstructive (
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| Veröffentlicht in: | Journal of cardiovascular computed tomography 2018-05, Vol.12 (3), p.231-237 |
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| creator | Weir-McCall, Jonathan R. Blanke, Philipp Sellers, Stephanie L. Ahmadi, Amir A. Andreini, Daniele Budoff, Matthew J. Cademartiri, Filippo Chinnaiyan, Kavitha Choi, Jung Hyun Chun, Eun Ju Conte, Edoardo Gottlieb, Ilan Hadamitzky, Martin Kim, Yong Jin Lee, Byoung Kwon Lee, Sang-Eun Maffei, Erica Marques, Hugo Pontone, Gianluca Raff, Gilbert L. Shin, Sanghoon Sung, Ji Min Stone, Peter Samady, Habib Virmani, Renu Narula, Jagat Berman, Daniel S. Shaw, Leslee J. Bax, Jeroen J. Lin, Fay Y. Min, James K. Chang, Hyuk-Jae Leipsic, Jonathon A. |
| description | The aim of the study is examine the impact of non-obstructive ( |
| doi_str_mv | 10.1016/j.jcct.2018.05.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2045288607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S193459251830114X</els_id><sourcerecordid>2045288607</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-ac1260fbbc1c9c76a28912e435880ddc64d93b93fc46c69ca4c4d62f6ca5dabb3</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EoqXwAhyQj1wSxk7idRCXVSllpbYgBBI3yxlPwKtNvNhOpb59vdqFI6cZS___yfMx9lpALUCod9t6i5hrCULX0NUgxBN2LvRKVVqJn0_L3jdt1fWyO2MvUtoCdCsB-jk7k70GCY08Z_Nm2lvMPIz8LsxVGFKOC2Z_T3xHY-aT9TN3PpFNxMPM82_i-xh-RUrJl3fpYYhhtvGB25ipjFP6PV_zr-tv64-b61uelgJe3MNL9my0u0SvTvOC_fh09f3yc3Xz5Xpzub6psAXIlUUhFYzDgAJ7XCkrdS8ktU2nNTiHqnV9M_TNiK1C1aNtsXVKjgpt5-wwNBfs7ZFb_vpnoZTN5BPSbmdnCksyEtpOaq1gVaLyGMUYUoo0mn30U7nHCDAHz2ZrDp7NwbOBzhTPpfTmxF-Gidy_yl-xJfDhGKBy5b2naBJ6mpGcj1RgLvj_8R8BOoiP6g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2045288607</pqid></control><display><type>article</type><title>Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Weir-McCall, Jonathan R. ; Blanke, Philipp ; Sellers, Stephanie L. ; Ahmadi, Amir A. ; Andreini, Daniele ; Budoff, Matthew J. ; Cademartiri, Filippo ; Chinnaiyan, Kavitha ; Choi, Jung Hyun ; Chun, Eun Ju ; Conte, Edoardo ; Gottlieb, Ilan ; Hadamitzky, Martin ; Kim, Yong Jin ; Lee, Byoung Kwon ; Lee, Sang-Eun ; Maffei, Erica ; Marques, Hugo ; Pontone, Gianluca ; Raff, Gilbert L. ; Shin, Sanghoon ; Sung, Ji Min ; Stone, Peter ; Samady, Habib ; Virmani, Renu ; Narula, Jagat ; Berman, Daniel S. ; Shaw, Leslee J. ; Bax, Jeroen J. ; Lin, Fay Y. ; Min, James K. ; Chang, Hyuk-Jae ; Leipsic, Jonathon A.</creator><creatorcontrib>Weir-McCall, Jonathan R. ; Blanke, Philipp ; Sellers, Stephanie L. ; Ahmadi, Amir A. ; Andreini, Daniele ; Budoff, Matthew J. ; Cademartiri, Filippo ; Chinnaiyan, Kavitha ; Choi, Jung Hyun ; Chun, Eun Ju ; Conte, Edoardo ; Gottlieb, Ilan ; Hadamitzky, Martin ; Kim, Yong Jin ; Lee, Byoung Kwon ; Lee, Sang-Eun ; Maffei, Erica ; Marques, Hugo ; Pontone, Gianluca ; Raff, Gilbert L. ; Shin, Sanghoon ; Sung, Ji Min ; Stone, Peter ; Samady, Habib ; Virmani, Renu ; Narula, Jagat ; Berman, Daniel S. ; Shaw, Leslee J. ; Bax, Jeroen J. ; Lin, Fay Y. ; Min, James K. ; Chang, Hyuk-Jae ; Leipsic, Jonathon A.</creatorcontrib><description>The aim of the study is examine the impact of non-obstructive (<50%stenosis) left main (LM) disease on the natural history of coronary artery disease using serial coronary computed tomography angiography (CTA).
CTAs from the PARADIGM (Progression of atherosclerotic plaque determined by computed tomographic angiography imaging) study, a prospective multinational registry of patients who underwent serial CTA at a ≥2 year interval were analyzed. Those without evidence of CAD on their baseline scan were excluded, as were those with obstructive left main disease. Coronary artery vessels and their branches underwent quantification of: plaque volume and composition; diameter stenosis; presence of high-risk plaque.
Of 944 (62 ± 9 years, 60% male) who had evidence of CAD at baseline, 444 (47%) had LM disease. Those with LM disease had a higher baseline plaque volume (194.8 ± 221mm3 versus 72.9 ± 84.3mm3, p < 0.001) and a higher prevalence of high-risk plaque (17.5% versus 13%, p < 0.001) than those without LM disease. On multivariable general linear model, patients with LM disease had greater annual rates of progression of total (26.5 ± 31.4mm3/yr versus 14.9 ± 20.1mm3/yr, p < 0.001) and calcified plaque volume (17 ± 24mm3/yr versus 7 ± 11mm3/yr, p < 0.001), with no difference in fibrous, fibrofatty or necrotic core plaque components.
The presence of non-obstructive LM disease is associated with greater rates of plaque progression and a higher prevalence of high-risk plaque throughout the entire coronary artery tree compared to CAD without LM involvement. Our data suggests that non-obstructive LM disease may be a marker for an aggressive phenotype of CAD that may benefit from more intensive treatment strategies.</description><identifier>ISSN: 1934-5925</identifier><identifier>EISSN: 1876-861X</identifier><identifier>DOI: 10.1016/j.jcct.2018.05.011</identifier><identifier>PMID: 29802032</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Chi-Square Distribution ; Computed Tomography Angiography ; Coronary Angiography - methods ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - pathology ; Coronary computed tomography angiography ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - epidemiology ; Coronary Stenosis - pathology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - pathology ; Disease Progression ; Female ; Fibrosis ; Humans ; Left main coronary artery disease ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Natural history ; Necrosis ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prevalence ; Registries ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Time Factors ; Vascular Calcification - diagnostic imaging ; Vascular Calcification - epidemiology ; Vascular Calcification - pathology</subject><ispartof>Journal of cardiovascular computed tomography, 2018-05, Vol.12 (3), p.231-237</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-ac1260fbbc1c9c76a28912e435880ddc64d93b93fc46c69ca4c4d62f6ca5dabb3</citedby><cites>FETCH-LOGICAL-c400t-ac1260fbbc1c9c76a28912e435880ddc64d93b93fc46c69ca4c4d62f6ca5dabb3</cites><orcidid>0000-0002-2348-2570 ; 0000-0001-8812-7388 ; 0000-0003-0402-5769</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcct.2018.05.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29802032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weir-McCall, Jonathan R.</creatorcontrib><creatorcontrib>Blanke, Philipp</creatorcontrib><creatorcontrib>Sellers, Stephanie L.</creatorcontrib><creatorcontrib>Ahmadi, Amir A.</creatorcontrib><creatorcontrib>Andreini, Daniele</creatorcontrib><creatorcontrib>Budoff, Matthew J.</creatorcontrib><creatorcontrib>Cademartiri, Filippo</creatorcontrib><creatorcontrib>Chinnaiyan, Kavitha</creatorcontrib><creatorcontrib>Choi, Jung Hyun</creatorcontrib><creatorcontrib>Chun, Eun Ju</creatorcontrib><creatorcontrib>Conte, Edoardo</creatorcontrib><creatorcontrib>Gottlieb, Ilan</creatorcontrib><creatorcontrib>Hadamitzky, Martin</creatorcontrib><creatorcontrib>Kim, Yong Jin</creatorcontrib><creatorcontrib>Lee, Byoung Kwon</creatorcontrib><creatorcontrib>Lee, Sang-Eun</creatorcontrib><creatorcontrib>Maffei, Erica</creatorcontrib><creatorcontrib>Marques, Hugo</creatorcontrib><creatorcontrib>Pontone, Gianluca</creatorcontrib><creatorcontrib>Raff, Gilbert L.</creatorcontrib><creatorcontrib>Shin, Sanghoon</creatorcontrib><creatorcontrib>Sung, Ji Min</creatorcontrib><creatorcontrib>Stone, Peter</creatorcontrib><creatorcontrib>Samady, Habib</creatorcontrib><creatorcontrib>Virmani, Renu</creatorcontrib><creatorcontrib>Narula, Jagat</creatorcontrib><creatorcontrib>Berman, Daniel S.</creatorcontrib><creatorcontrib>Shaw, Leslee J.</creatorcontrib><creatorcontrib>Bax, Jeroen J.</creatorcontrib><creatorcontrib>Lin, Fay Y.</creatorcontrib><creatorcontrib>Min, James K.</creatorcontrib><creatorcontrib>Chang, Hyuk-Jae</creatorcontrib><creatorcontrib>Leipsic, Jonathon A.</creatorcontrib><title>Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy</title><title>Journal of cardiovascular computed tomography</title><addtitle>J Cardiovasc Comput Tomogr</addtitle><description>The aim of the study is examine the impact of non-obstructive (<50%stenosis) left main (LM) disease on the natural history of coronary artery disease using serial coronary computed tomography angiography (CTA).
CTAs from the PARADIGM (Progression of atherosclerotic plaque determined by computed tomographic angiography imaging) study, a prospective multinational registry of patients who underwent serial CTA at a ≥2 year interval were analyzed. Those without evidence of CAD on their baseline scan were excluded, as were those with obstructive left main disease. Coronary artery vessels and their branches underwent quantification of: plaque volume and composition; diameter stenosis; presence of high-risk plaque.
Of 944 (62 ± 9 years, 60% male) who had evidence of CAD at baseline, 444 (47%) had LM disease. Those with LM disease had a higher baseline plaque volume (194.8 ± 221mm3 versus 72.9 ± 84.3mm3, p < 0.001) and a higher prevalence of high-risk plaque (17.5% versus 13%, p < 0.001) than those without LM disease. On multivariable general linear model, patients with LM disease had greater annual rates of progression of total (26.5 ± 31.4mm3/yr versus 14.9 ± 20.1mm3/yr, p < 0.001) and calcified plaque volume (17 ± 24mm3/yr versus 7 ± 11mm3/yr, p < 0.001), with no difference in fibrous, fibrofatty or necrotic core plaque components.
The presence of non-obstructive LM disease is associated with greater rates of plaque progression and a higher prevalence of high-risk plaque throughout the entire coronary artery tree compared to CAD without LM involvement. Our data suggests that non-obstructive LM disease may be a marker for an aggressive phenotype of CAD that may benefit from more intensive treatment strategies.</description><subject>Aged</subject><subject>Chi-Square Distribution</subject><subject>Computed Tomography Angiography</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary computed tomography angiography</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - epidemiology</subject><subject>Coronary Stenosis - pathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Left main coronary artery disease</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Natural history</subject><subject>Necrosis</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Registries</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Vascular Calcification - 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CTAs from the PARADIGM (Progression of atherosclerotic plaque determined by computed tomographic angiography imaging) study, a prospective multinational registry of patients who underwent serial CTA at a ≥2 year interval were analyzed. Those without evidence of CAD on their baseline scan were excluded, as were those with obstructive left main disease. Coronary artery vessels and their branches underwent quantification of: plaque volume and composition; diameter stenosis; presence of high-risk plaque.
Of 944 (62 ± 9 years, 60% male) who had evidence of CAD at baseline, 444 (47%) had LM disease. Those with LM disease had a higher baseline plaque volume (194.8 ± 221mm3 versus 72.9 ± 84.3mm3, p < 0.001) and a higher prevalence of high-risk plaque (17.5% versus 13%, p < 0.001) than those without LM disease. On multivariable general linear model, patients with LM disease had greater annual rates of progression of total (26.5 ± 31.4mm3/yr versus 14.9 ± 20.1mm3/yr, p < 0.001) and calcified plaque volume (17 ± 24mm3/yr versus 7 ± 11mm3/yr, p < 0.001), with no difference in fibrous, fibrofatty or necrotic core plaque components.
The presence of non-obstructive LM disease is associated with greater rates of plaque progression and a higher prevalence of high-risk plaque throughout the entire coronary artery tree compared to CAD without LM involvement. Our data suggests that non-obstructive LM disease may be a marker for an aggressive phenotype of CAD that may benefit from more intensive treatment strategies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29802032</pmid><doi>10.1016/j.jcct.2018.05.011</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2348-2570</orcidid><orcidid>https://orcid.org/0000-0001-8812-7388</orcidid><orcidid>https://orcid.org/0000-0003-0402-5769</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1934-5925 |
| ispartof | Journal of cardiovascular computed tomography, 2018-05, Vol.12 (3), p.231-237 |
| issn | 1934-5925 1876-861X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2045288607 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Chi-Square Distribution Computed Tomography Angiography Coronary Angiography - methods Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Artery Disease - pathology Coronary computed tomography angiography Coronary Stenosis - diagnostic imaging Coronary Stenosis - epidemiology Coronary Stenosis - pathology Coronary Vessels - diagnostic imaging Coronary Vessels - pathology Disease Progression Female Fibrosis Humans Left main coronary artery disease Linear Models Male Middle Aged Multivariate Analysis Natural history Necrosis Plaque, Atherosclerotic Predictive Value of Tests Prevalence Registries Risk Assessment Risk Factors Severity of Illness Index Time Factors Vascular Calcification - diagnostic imaging Vascular Calcification - epidemiology Vascular Calcification - pathology |
| title | Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T02%3A10%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Non-obstructive%20left%20main%20disease%20on%20the%20progression%20of%20coronary%20artery%20disease:%20A%20PARADIGM%20substudy&rft.jtitle=Journal%20of%20cardiovascular%20computed%20tomography&rft.au=Weir-McCall,%20Jonathan%20R.&rft.date=2018-05&rft.volume=12&rft.issue=3&rft.spage=231&rft.epage=237&rft.pages=231-237&rft.issn=1934-5925&rft.eissn=1876-861X&rft_id=info:doi/10.1016/j.jcct.2018.05.011&rft_dat=%3Cproquest_cross%3E2045288607%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2045288607&rft_id=info:pmid/29802032&rft_els_id=S193459251830114X&rfr_iscdi=true |