Protective immune response against Toxoplasma gondii elicited by a novel yeast-based vaccine with microneme protein 16

Toxoplasma gondii is an obligate intracellular protozoan that can invade all eukaryotic cells and infect all warm-blood animals, causing the important zoonosis toxoplasmosis. Invasion of host cells is the key step necessary for T. gondii to complete its life cycle and microneme proteins play an impo...

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Veröffentlicht in:	Vaccine 2018-06, Vol.36 (27), p.3943-3948
Hauptverfasser:	Wang, Long-jiang, Xiao, Ting, Xu, Chao, Li, Jin, Liu, Gong-zhen, Yin, Kun, Cui, Yong, Wei, Qing-kuan, Huang, Bing-cheng, Sun, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Antigens Baking yeast CD4 antigen CD8 antigen Cell surface Drug resistance Female Humans Immune response Immune response (cell-mediated) Immune response (humoral) Immune system Immunity, Cellular - immunology Immunity, Humoral - immunology Immunization Infections Injections, Intraperitoneal Laboratory animals Life cycle engineering Life cycles Lymphocytes Lymphocytes T Male Mice Mice, Inbred BALB C Microneme protein 16 Minimum inhibitory concentration Parasites Plasmids Proteins Protozoa Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Vaccines - immunology Protozoan Vaccines - therapeutic use Receptors Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - immunology Survival Toxoplasma Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis Toxoplasmosis - prevention & control Toxoplasmosis - therapy Vaccines Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use Yeast Yeast-based vaccine Yeasts
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