Atorvastatin and Caffeine in Combination Regulates Apoptosis, Migration, Invasion and Tumorspheres of Prostate Cancer Cells

Atorvastatin is the most prescribed cholesterol-lowering statin, while caffeine enhances chemo-sensitivity and induces apoptosis of tumor cells through its DNA repair-inhibiting effect. The present study investigated the effects and mechanisms of atorvastatin and caffeine in combination on human pro...

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Veröffentlicht in:	Pathology oncology research 2020-01, Vol.26 (1), p.209-216
Hauptverfasser:	Wang, Zhenshi, Zhang, Lanyue, Wan, Zheng, He, Yan, Huang, Huarong, Xiang, Hongping, Wu, Xiaofeng, Zhang, Kun, Liu, Yang, Goodin, Susan, Du, Zhiyun, Zheng, Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Apoptosis Apoptosis - drug effects Assaying Atorvastatin Atorvastatin - pharmacology Bcl-2 protein Biomedical and Life Sciences Biomedicine Caffeine Caffeine - pharmacology Cancer Research Cell adhesion & migration Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Cholesterol DNA repair Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Immunology Male Oncology Original Article Pathology PC-3 Cells Phosphodiesterase Inhibitors - pharmacology Prostate cancer Prostatic Neoplasms - pathology Proteins Serum-free medium Survivin Tumor cells Wound healing
Online-Zugang:	Volltext
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