PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5

Th17 cells are a class of Th cells that secrete IL-17 and mediate pathogenic immunity responsible for autoimmunity including experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis. Retinoic acid-related orphan receptor γ t (RORγt) is the critical transcription factor that co...

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Veröffentlicht in:	The Journal of immunology (1950) 2018-07, Vol.201 (2), p.440-450
Hauptverfasser:	Sen, Subha, He, Zhiheng, Ghosh, Shubhamoy, Dery, Kenneth J, Yang, Lu, Zhang, Jing, Sun, Zuoming
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animal models Animals Arginine Autoimmunity Autoimmunity - immunology Cell Differentiation - immunology Cofactors Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Experimental allergic encephalomyelitis Foxp3 protein Helper cells Immunoregulation Inactivation Inhibition Interleukin 17 Interleukin 2 Interleukin-17 - immunology Lymphocytes Lymphocytes T Mice Mice, Inbred C57BL Multiple sclerosis N-Methyltransferase Protein-Arginine N-Methyltransferases - metabolism Receptors, Retinoic Acid - metabolism Recruitment Retinoic acid Retinoic Acid Receptor gamma Sclerosis Stat3 protein STAT3 Transcription Factor - metabolism Stat5 protein STAT5 Transcription Factor - metabolism Th17 Cells - immunology Th17 Cells - metabolism
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