Subthalamic nucleus deep brain stimulation protects neurons by activating autophagy via PP2A inactivation in a rat model of Parkinson's disease

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapeutic strategy for alleviating disability in patients with moderate to severe Parkinson's disease (PD). Preclinical studies have shown that stimulation of the rat STN can protect against nigral dopaminergic neur...

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Veröffentlicht in:	Experimental neurology 2018-08, Vol.306, p.232-242
Hauptverfasser:	Du, Ting-Ting, Chen, Ying-Chuan, Lu, Yong-Quan, Meng, Fan-Gang, Yang, Hui, Zhang, Jian-Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy Beclin-1 - metabolism Caspases - metabolism Deep Brain Stimulation Male Neuroprotective Agents Oxidopamine Parkinson Disease - metabolism Parkinson Disease - therapy Parkinson's disease Protein Phosphatase 2 - antagonists & inhibitors Protein Phosphatase 2 - metabolism Protein phosphatase 2A Psychomotor Performance Rats Rats, Sprague-Dawley Subthalamic Nucleus Sympatholytics Tyrosine 3-Monooxygenase - metabolism
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