Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys
Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison wi...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.101-104 |
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| creator | Agrba, V. Z. Karal-Ogly, D. D. Gvozdik, T. E. Kaplanyan, P. A. Demenkova, N. P. Gvaramiya, I. A. Mukhametzyanova, E. I. Shamsutdinova, O. A. Chuguev, Yu. P. Kal’sina, S. Sh Konoplyannikov, A. G. Araviashvili, D. E. Klots, I. N. Lapin, B. A. |
| description | Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison with 50-74 days in animals receiving stem cells before doxorubicin. Controls received doxorubicin and saline; the lifespan of one monkey was 24 days, of the other — 1 year and 8 months. The increase in activity of proinflammatory cytokine IL-6 was paralleled by an increase in the level of C-reactive protein. |
| doi_str_mv | 10.1007/s10517-018-4108-8 |
| format | Article |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Analysis Animals Anthracyclines B cells B-Lymphocytes - drug effects B-Lymphocytes - metabolism Biomedical and Life Sciences Biomedicine C-reactive protein Cachexia Cell Biology Cytokines Cytokines - metabolism Degeneration Doxorubicin Doxorubicin - adverse effects Inflammation Interleukin 6 Interleukin-6 - metabolism Internal Medicine Intoxication Laboratory Medicine Life span Macaca mulatta Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - physiology Mesenchyme Pathology Primatology Stem cell transplantation Stem cells Stem Cells - drug effects Stem Cells - metabolism Viscera |
| title | Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys |
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