Dynamics of Expression of Cytokine Genes and Macrophage Content in the Lungs and Kidneys after Subtotal Hepatectomy in Rats
The role of the lungs and kidneys in liver regeneration after subtotal hepatectomy was studied on a rat model. It was found that production of hepatocyte growth factor (HGF) in the lungs and kidneys and expression of cytokine genes Il1b , Il6 , Il10 , and tnfa significantly increased. Analysis of th...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.136-141 |
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| creator | El’chaninov, A. V. Fatkhudinov, T. Kh Arutyunyan, I. V. Makarov, A. V. Usman, N. Yu Mikhailova, L. P. Lokhonina, A. V. Botchey, V. M. Glinkina, V. V. Bol’shakova, G. B. |
| description | The role of the lungs and kidneys in liver regeneration after subtotal hepatectomy was studied on a rat model. It was found that production of hepatocyte growth factor (HGF) in the lungs and kidneys and expression of cytokine genes
Il1b
,
Il6
,
Il10
, and
tnfa
significantly increased. Analysis of the dynamics of lung macrophage population showed that accumulation of HGF and the increase in the expression of cytokine genes in the lungs were accompanied by simultaneous increase in the number of CD68
+
cells, which attested to the leading role of macrophages in activation of HGF synthesis in the lungs. Macrophage content in the kidneys after subtotal hepatectomy did not increase. |
| doi_str_mv | 10.1007/s10517-018-4115-9 |
| format | Article |
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Il1b
,
Il6
,
Il10
, and
tnfa
significantly increased. Analysis of the dynamics of lung macrophage population showed that accumulation of HGF and the increase in the expression of cytokine genes in the lungs were accompanied by simultaneous increase in the number of CD68
+
cells, which attested to the leading role of macrophages in activation of HGF synthesis in the lungs. Macrophage content in the kidneys after subtotal hepatectomy did not increase.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4115-9</identifier><identifier>PMID: 29796817</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cytokines ; Genes ; Hepatectomy ; Interleukin-10 - metabolism ; Interleukin-1beta - metabolism ; Internal Medicine ; Kidney - metabolism ; Laboratory Medicine ; Liver ; Liver Regeneration - physiology ; Lung - metabolism ; Macrophages ; Macrophages - metabolism ; Pathology ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2018-05, Vol.165 (1), p.136-141</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-2130c607e50748d117459d1e2a86f071e3f1be5e7f9f15f8556c6cdd5ea503c63</citedby><cites>FETCH-LOGICAL-c442t-2130c607e50748d117459d1e2a86f071e3f1be5e7f9f15f8556c6cdd5ea503c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-018-4115-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-018-4115-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29796817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El’chaninov, A. V.</creatorcontrib><creatorcontrib>Fatkhudinov, T. Kh</creatorcontrib><creatorcontrib>Arutyunyan, I. V.</creatorcontrib><creatorcontrib>Makarov, A. V.</creatorcontrib><creatorcontrib>Usman, N. Yu</creatorcontrib><creatorcontrib>Mikhailova, L. P.</creatorcontrib><creatorcontrib>Lokhonina, A. V.</creatorcontrib><creatorcontrib>Botchey, V. M.</creatorcontrib><creatorcontrib>Glinkina, V. V.</creatorcontrib><creatorcontrib>Bol’shakova, G. B.</creatorcontrib><title>Dynamics of Expression of Cytokine Genes and Macrophage Content in the Lungs and Kidneys after Subtotal Hepatectomy in Rats</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The role of the lungs and kidneys in liver regeneration after subtotal hepatectomy was studied on a rat model. It was found that production of hepatocyte growth factor (HGF) in the lungs and kidneys and expression of cytokine genes
Il1b
,
Il6
,
Il10
, and
tnfa
significantly increased. Analysis of the dynamics of lung macrophage population showed that accumulation of HGF and the increase in the expression of cytokine genes in the lungs were accompanied by simultaneous increase in the number of CD68
+
cells, which attested to the leading role of macrophages in activation of HGF synthesis in the lungs. Macrophage content in the kidneys after subtotal hepatectomy did not increase.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cytokines</subject><subject>Genes</subject><subject>Hepatectomy</subject><subject>Interleukin-10 - metabolism</subject><subject>Interleukin-1beta - metabolism</subject><subject>Internal Medicine</subject><subject>Kidney - metabolism</subject><subject>Laboratory Medicine</subject><subject>Liver</subject><subject>Liver Regeneration - physiology</subject><subject>Lung - metabolism</subject><subject>Macrophages</subject><subject>Macrophages - metabolism</subject><subject>Pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV-L1TAQxYMo7t3VD-CLBATZl66Ztmnax-W67opXBP88h9x0cm_XNukmKVj88qZ0FRdE8pDM5HcG5hxCXgC7AMbEmwCMg8gY1FkJwLPmEdkAF0VW5zk8JhuWoKys6_qEnIZwu5SsgqfkJG9EU9UgNuTn29mqodOBOkOvfoweQ-icXartHN33ziK9RouBKtvSj0p7Nx7VAenW2Yg20s7SeES6m-xhZT50rcU5vU1ET79M--ii6ukNjiqijm6YF81nFcMz8sSoPuDz-_uMfHt39XV7k-0-Xb_fXu4yXZZ5zHIomK6YQM5EWbcAouRNC5irujJMABYG9shRmMYANzXnla5023JUnBW6Ks7I-Tp39O5uwhDl0AWNfa8suinInJU8F3lV8YS-WtGD6lF21rjolV5wecnLkieX-UJd_INKp8VkpbNoutR_IHj9l-CIqo_H4PopJqvDQxBWMPkcgkcjR98Nys8SmFwyl2vmMmUul8xlkzQv79eb9gO2fxS_Q05AvgIhfdkDennrJm-T5f-Z-guJO7TX</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>El’chaninov, A. 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V.</creatorcontrib><creatorcontrib>Fatkhudinov, T. Kh</creatorcontrib><creatorcontrib>Arutyunyan, I. V.</creatorcontrib><creatorcontrib>Makarov, A. V.</creatorcontrib><creatorcontrib>Usman, N. Yu</creatorcontrib><creatorcontrib>Mikhailova, L. P.</creatorcontrib><creatorcontrib>Lokhonina, A. V.</creatorcontrib><creatorcontrib>Botchey, V. M.</creatorcontrib><creatorcontrib>Glinkina, V. V.</creatorcontrib><creatorcontrib>Bol’shakova, G. B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El’chaninov, A. V.</au><au>Fatkhudinov, T. Kh</au><au>Arutyunyan, I. 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Il1b
,
Il6
,
Il10
, and
tnfa
significantly increased. Analysis of the dynamics of lung macrophage population showed that accumulation of HGF and the increase in the expression of cytokine genes in the lungs were accompanied by simultaneous increase in the number of CD68
+
cells, which attested to the leading role of macrophages in activation of HGF synthesis in the lungs. Macrophage content in the kidneys after subtotal hepatectomy did not increase.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29796817</pmid><doi>10.1007/s10517-018-4115-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Cell Biology Cytokines Genes Hepatectomy Interleukin-10 - metabolism Interleukin-1beta - metabolism Internal Medicine Kidney - metabolism Laboratory Medicine Liver Liver Regeneration - physiology Lung - metabolism Macrophages Macrophages - metabolism Pathology Rats Rats, Wistar Tumor Necrosis Factor-alpha - metabolism |
| title | Dynamics of Expression of Cytokine Genes and Macrophage Content in the Lungs and Kidneys after Subtotal Hepatectomy in Rats |
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