Short-term effect of additional apheresis on visual acuity changes in patients with steroid-resistant optic neuritis in neuromyelitis optica spectrum disorders
Purpose To evaluate temporal changes in visual acuity in patients with steroid-resistant optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) after apheresis. Design Retrospective observational study, clinical case series Subjects and methods We reviewed the medical charts of 15 ey...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2018-07, Vol.62 (4), p.525-530 |
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| container_title | Japanese journal of ophthalmology |
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| creator | Mori, Sotaro Kurimoto, Takuji Ueda, Kaori Nakamura, Makoto |
| description | Purpose
To evaluate temporal changes in visual acuity in patients with steroid-resistant optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) after apheresis.
Design
Retrospective observational study, clinical case series
Subjects and methods
We reviewed the medical charts of 15 eyes of 9 consecutive patients with ON in NMOSD who underwent apheresis between March 2010 and September 2017. All patients were seropositive for anti-aquaporin 4 (AQP4) antibody and resistant to steroid pulse therapy. Apheresis was performed by either simple plasma exchange or/and immune adsorption therapy.
Results
Twelve eyes (80%) showed improvement with logMAR > 0.3 at 1 month after apheresis. Within 1 month after apheresis therapy, logMAR on average significantly decreased, the magnitude of change being greatest within the first week. Thereafter visual acuity became stable in 10 of the 11 eyes, until 12 months. However, two eyes (12%) showed recurrence of visual acuity reduction 3 months after the cessation of apheresis. There were a few serious complications during and after apheresis, but these were completely treatable.
Conclusions
Additional apheresis therapy rapidly improves the visual acuity of steroid-resistant seropositive AQP4 ON. |
| doi_str_mv | 10.1007/s10384-018-0602-9 |
| format | Article |
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To evaluate temporal changes in visual acuity in patients with steroid-resistant optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) after apheresis.
Design
Retrospective observational study, clinical case series
Subjects and methods
We reviewed the medical charts of 15 eyes of 9 consecutive patients with ON in NMOSD who underwent apheresis between March 2010 and September 2017. All patients were seropositive for anti-aquaporin 4 (AQP4) antibody and resistant to steroid pulse therapy. Apheresis was performed by either simple plasma exchange or/and immune adsorption therapy.
Results
Twelve eyes (80%) showed improvement with logMAR > 0.3 at 1 month after apheresis. Within 1 month after apheresis therapy, logMAR on average significantly decreased, the magnitude of change being greatest within the first week. Thereafter visual acuity became stable in 10 of the 11 eyes, until 12 months. However, two eyes (12%) showed recurrence of visual acuity reduction 3 months after the cessation of apheresis. There were a few serious complications during and after apheresis, but these were completely treatable.
Conclusions
Additional apheresis therapy rapidly improves the visual acuity of steroid-resistant seropositive AQP4 ON.</description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-018-0602-9</identifier><identifier>PMID: 29802557</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Acuity ; Adsorption ; Apheresis ; Aquaporin 4 ; Clinical Investigation ; Complications ; Disorders ; Eye ; Eye (anatomy) ; Eye diseases ; Immune adsorption ; Medicine ; Medicine & Public Health ; Neuritis ; Neuromyelitis ; Ophthalmology ; Optic neuritis ; Patients ; Therapy ; Visual acuity</subject><ispartof>Japanese journal of ophthalmology, 2018-07, Vol.62 (4), p.525-530</ispartof><rights>Japanese Ophthalmological Society 2018</rights><rights>Japanese Journal of Ophthalmology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-71b7a70468d17f8cf6eccf3a6ea2f2103fcc111aa98769a3b3cc009c2c8e1dda3</citedby><cites>FETCH-LOGICAL-c396t-71b7a70468d17f8cf6eccf3a6ea2f2103fcc111aa98769a3b3cc009c2c8e1dda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-018-0602-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-018-0602-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29802557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mori, Sotaro</creatorcontrib><creatorcontrib>Kurimoto, Takuji</creatorcontrib><creatorcontrib>Ueda, Kaori</creatorcontrib><creatorcontrib>Nakamura, Makoto</creatorcontrib><title>Short-term effect of additional apheresis on visual acuity changes in patients with steroid-resistant optic neuritis in neuromyelitis optica spectrum disorders</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Purpose
To evaluate temporal changes in visual acuity in patients with steroid-resistant optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) after apheresis.
Design
Retrospective observational study, clinical case series
Subjects and methods
We reviewed the medical charts of 15 eyes of 9 consecutive patients with ON in NMOSD who underwent apheresis between March 2010 and September 2017. All patients were seropositive for anti-aquaporin 4 (AQP4) antibody and resistant to steroid pulse therapy. Apheresis was performed by either simple plasma exchange or/and immune adsorption therapy.
Results
Twelve eyes (80%) showed improvement with logMAR > 0.3 at 1 month after apheresis. Within 1 month after apheresis therapy, logMAR on average significantly decreased, the magnitude of change being greatest within the first week. Thereafter visual acuity became stable in 10 of the 11 eyes, until 12 months. However, two eyes (12%) showed recurrence of visual acuity reduction 3 months after the cessation of apheresis. There were a few serious complications during and after apheresis, but these were completely treatable.
Conclusions
Additional apheresis therapy rapidly improves the visual acuity of steroid-resistant seropositive AQP4 ON.</description><subject>Acuity</subject><subject>Adsorption</subject><subject>Apheresis</subject><subject>Aquaporin 4</subject><subject>Clinical Investigation</subject><subject>Complications</subject><subject>Disorders</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Eye diseases</subject><subject>Immune adsorption</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuritis</subject><subject>Neuromyelitis</subject><subject>Ophthalmology</subject><subject>Optic neuritis</subject><subject>Patients</subject><subject>Therapy</subject><subject>Visual acuity</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kc2KFTEQhYMoznX0AdxIwI2baFX6fymDPwMDLtR1k5uueDN0d9pU2uE-ja9qbt9RQXCVUPWdk3COEM8RXiNA84YRirZUgK2CGrTqHogd1lgorcv6odgBaFQVVtWFeMJ8CwClLvRjcaG7FnRVNTvx8_MhxKQSxUmSc2STDE6aYfDJh9mM0iwHisSeZZjlD8_raWZXn47SHsz8jVj6WS4meZoTyzufDpKzXfCD2nTJzNlzSd7KmdaYfTfF6R6mI43bYNsbyUv-QFwnOXgOcaDIT8UjZ0amZ_fnpfj6_t2Xq4_q5tOH66u3N8oWXZ1Ug_vGNFDW7YCNa62ryVpXmJqMdjrH5KxFRGO6tqk7U-wLawE6q21LOAymuBSvzr5LDN9X4tRPni2No5kprNxrKCvdYFPpjL78B70Na8xZbVQJiG2FmcIzZWNgjuT6JfrJxGOP0J_a68_t9bm9_tRe32XNi3vndT_R8Efxu64M6DPAeZWzj3-f_r_rL0-sqas</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Mori, Sotaro</creator><creator>Kurimoto, Takuji</creator><creator>Ueda, Kaori</creator><creator>Nakamura, Makoto</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20180701</creationdate><title>Short-term effect of additional apheresis on visual acuity changes in patients with steroid-resistant optic neuritis in neuromyelitis optica spectrum disorders</title><author>Mori, Sotaro ; Kurimoto, Takuji ; Ueda, Kaori ; Nakamura, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-71b7a70468d17f8cf6eccf3a6ea2f2103fcc111aa98769a3b3cc009c2c8e1dda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acuity</topic><topic>Adsorption</topic><topic>Apheresis</topic><topic>Aquaporin 4</topic><topic>Clinical Investigation</topic><topic>Complications</topic><topic>Disorders</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Eye diseases</topic><topic>Immune adsorption</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuritis</topic><topic>Neuromyelitis</topic><topic>Ophthalmology</topic><topic>Optic neuritis</topic><topic>Patients</topic><topic>Therapy</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mori, Sotaro</creatorcontrib><creatorcontrib>Kurimoto, Takuji</creatorcontrib><creatorcontrib>Ueda, Kaori</creatorcontrib><creatorcontrib>Nakamura, Makoto</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mori, Sotaro</au><au>Kurimoto, Takuji</au><au>Ueda, Kaori</au><au>Nakamura, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term effect of additional apheresis on visual acuity changes in patients with steroid-resistant optic neuritis in neuromyelitis optica spectrum disorders</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>62</volume><issue>4</issue><spage>525</spage><epage>530</epage><pages>525-530</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><abstract>Purpose
To evaluate temporal changes in visual acuity in patients with steroid-resistant optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) after apheresis.
Design
Retrospective observational study, clinical case series
Subjects and methods
We reviewed the medical charts of 15 eyes of 9 consecutive patients with ON in NMOSD who underwent apheresis between March 2010 and September 2017. All patients were seropositive for anti-aquaporin 4 (AQP4) antibody and resistant to steroid pulse therapy. Apheresis was performed by either simple plasma exchange or/and immune adsorption therapy.
Results
Twelve eyes (80%) showed improvement with logMAR > 0.3 at 1 month after apheresis. Within 1 month after apheresis therapy, logMAR on average significantly decreased, the magnitude of change being greatest within the first week. Thereafter visual acuity became stable in 10 of the 11 eyes, until 12 months. However, two eyes (12%) showed recurrence of visual acuity reduction 3 months after the cessation of apheresis. There were a few serious complications during and after apheresis, but these were completely treatable.
Conclusions
Additional apheresis therapy rapidly improves the visual acuity of steroid-resistant seropositive AQP4 ON.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>29802557</pmid><doi>10.1007/s10384-018-0602-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Japanese journal of ophthalmology, 2018-07, Vol.62 (4), p.525-530 |
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| subjects | Acuity Adsorption Apheresis Aquaporin 4 Clinical Investigation Complications Disorders Eye Eye (anatomy) Eye diseases Immune adsorption Medicine Medicine & Public Health Neuritis Neuromyelitis Ophthalmology Optic neuritis Patients Therapy Visual acuity |
| title | Short-term effect of additional apheresis on visual acuity changes in patients with steroid-resistant optic neuritis in neuromyelitis optica spectrum disorders |
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