A New Class of 1‐Aryl‐5,6‐dihydropyrrolo[2,1‐a]isoquinoline Derivatives as Reversers of P‐Glycoprotein‐Mediated Multidrug Resistance in Tumor Cells

A number of aza‐heterocyclic compounds, which share the 5,6‐dihydropyrrolo[2,1‐a]isoquinoline (DHPIQ) scaffold with members of the lamellarin alkaloid family, were synthesized and evaluated for their ability to reverse in vitro multidrug resistance in cancer cells through inhibition of P‐glycoprotei...

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Veröffentlicht in:	ChemMedChem 2018-08, Vol.13 (15), p.1588-1596
Hauptverfasser:	Nevskaya, Alisa A., Matveeva, Maria D., Borisova, Tatiana N., Niso, Mauro, Colabufo, Nicola A., Boccarelli, Angelina, Purgatorio, Rosa, de Candia, Modesto, Cellamare, Saverio, Voskressensky, Leonid G., Altomare, Cosimo D.
Format:	Artikel
Sprache:	eng
Schlagworte:	efflux transporters multidrug resistance P-glycoproteins pyrrolo[2,1-a]isoquinolines structure–activity relationships
Online-Zugang:	Volltext
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