Vascularization of the Damaged Nerve under the Effect of Experimental Cell Therapy
Quantitative analysis of blood vessels in the distal segment of rat sciatic nerve after its ligation for 40 sec and subperineurial administration of mesenchymal stem cells or dissociated cells of rat embryonic spinal cord was carried our by immunohistochemical tracing of von Willebrand factor, a mar...
Gespeichert in:
| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.161-165 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 165 |
|---|---|
| container_issue | 1 |
| container_start_page | 161 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 165 |
| creator | Petrova, E. S. Isaeva, E. N. Kolos, E. A. Korzhevskii, D. E |
| description | Quantitative analysis of blood vessels in the distal segment of rat sciatic nerve after its ligation for 40 sec and subperineurial administration of mesenchymal stem cells or dissociated cells of rat embryonic spinal cord was carried our by immunohistochemical tracing of von Willebrand factor, a marker of endothelial cells of blood vessels. It was found that the number of blood vessels per unit area of the nerve trunk in 21 days after injury and administration of mesenchymal stem cells increased by more than 1.5 times in comparison with the control (damaged nerve). After administration of dissociated cells of the embryonic spinal cord, this effect was not observed. It is assumed that mesenchymal stem cells stimulate the growth of vessels of the damaged nerve via production of angiogenic factors. |
| doi_str_mv | 10.1007/s10517-018-4120-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2045268937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A544511560</galeid><sourcerecordid>A544511560</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-89d8d0ab0d4092fb66faee2a2d5e7a423f001578eed2df7223c1863c598842bd3</originalsourceid><addsrcrecordid>eNp1kUFv1DAQhS1ERZfCD-CCIiEhLiljx46dY7UsUKkqEipcLa893k2VxIudILq_HoctLUUgHyyPv_c0M4-QFxROKYB8mygIKkugquSUQbl_RBZUyKpUjNHHZAEZKrlS6pg8Tel6fkJNn5Bj1shG0kouyOevJtmpM7Hdm7ENQxF8MW6xeGd6s0FXXGL8jsU0OIy_6ivv0Y4ztfqxw9j2OIymK5bYdcXVFqPZ3TwjR950CZ_f3ifky_vV1fJjefHpw_ny7KK0XMJYqsYpB2YNjkPD_LquvUFkhjmB0nBWeYA8jEJ0zHnJWGWpqisrGqU4W7vqhLw5-O5i-DZhGnXfJpsbMQOGKWkGXLBaNZXM6Ku_0OswxSF3N1OVgAyJe2pjOtTt4MMYjZ1N9ZngXFAqasjU6T-ofBz2rQ0D-jbXHwhe_yHYounGbQrdNK87PQTpAbQxpBTR611esIk3moKeA9eHwHUOXM-B633WvLydbFr36O4UvxPOADsAKX8NG4z3o__f9SckT7Km</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2043509375</pqid></control><display><type>article</type><title>Vascularization of the Damaged Nerve under the Effect of Experimental Cell Therapy</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Petrova, E. S. ; Isaeva, E. N. ; Kolos, E. A. ; Korzhevskii, D. E</creator><creatorcontrib>Petrova, E. S. ; Isaeva, E. N. ; Kolos, E. A. ; Korzhevskii, D. E</creatorcontrib><description>Quantitative analysis of blood vessels in the distal segment of rat sciatic nerve after its ligation for 40 sec and subperineurial administration of mesenchymal stem cells or dissociated cells of rat embryonic spinal cord was carried our by immunohistochemical tracing of von Willebrand factor, a marker of endothelial cells of blood vessels. It was found that the number of blood vessels per unit area of the nerve trunk in 21 days after injury and administration of mesenchymal stem cells increased by more than 1.5 times in comparison with the control (damaged nerve). After administration of dissociated cells of the embryonic spinal cord, this effect was not observed. It is assumed that mesenchymal stem cells stimulate the growth of vessels of the damaged nerve via production of angiogenic factors.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4120-z</identifier><identifier>PMID: 29797137</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Angiogenesis ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood vessels ; Cell Biology ; Cell- and Tissue-Based Therapy ; Endothelial cells ; Immunohistochemistry ; Internal Medicine ; Laboratory Medicine ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - physiology ; Mesenchyme ; Nerve Regeneration - physiology ; Pathology ; Peripheral Nerve Injuries - metabolism ; Peripheral Nerve Injuries - therapy ; Rats ; Rats, Wistar ; Sciatic nerve ; Sciatic Nerve - injuries ; Sciatic Nerve - metabolism ; Sciatic Nerve - physiology ; Spinal cord ; Spinal Cord - embryology ; Stem cell transplantation ; Stem cells ; Vascularization ; Von Willebrand factor ; von Willebrand Factor - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2018-05, Vol.165 (1), p.161-165</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-89d8d0ab0d4092fb66faee2a2d5e7a423f001578eed2df7223c1863c598842bd3</citedby><cites>FETCH-LOGICAL-c470t-89d8d0ab0d4092fb66faee2a2d5e7a423f001578eed2df7223c1863c598842bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-018-4120-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-018-4120-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29797137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrova, E. S.</creatorcontrib><creatorcontrib>Isaeva, E. N.</creatorcontrib><creatorcontrib>Kolos, E. A.</creatorcontrib><creatorcontrib>Korzhevskii, D. E</creatorcontrib><title>Vascularization of the Damaged Nerve under the Effect of Experimental Cell Therapy</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Quantitative analysis of blood vessels in the distal segment of rat sciatic nerve after its ligation for 40 sec and subperineurial administration of mesenchymal stem cells or dissociated cells of rat embryonic spinal cord was carried our by immunohistochemical tracing of von Willebrand factor, a marker of endothelial cells of blood vessels. It was found that the number of blood vessels per unit area of the nerve trunk in 21 days after injury and administration of mesenchymal stem cells increased by more than 1.5 times in comparison with the control (damaged nerve). After administration of dissociated cells of the embryonic spinal cord, this effect was not observed. It is assumed that mesenchymal stem cells stimulate the growth of vessels of the damaged nerve via production of angiogenic factors.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood vessels</subject><subject>Cell Biology</subject><subject>Cell- and Tissue-Based Therapy</subject><subject>Endothelial cells</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stromal Cells - physiology</subject><subject>Mesenchyme</subject><subject>Nerve Regeneration - physiology</subject><subject>Pathology</subject><subject>Peripheral Nerve Injuries - metabolism</subject><subject>Peripheral Nerve Injuries - therapy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sciatic nerve</subject><subject>Sciatic Nerve - injuries</subject><subject>Sciatic Nerve - metabolism</subject><subject>Sciatic Nerve - physiology</subject><subject>Spinal cord</subject><subject>Spinal Cord - embryology</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Vascularization</subject><subject>Von Willebrand factor</subject><subject>von Willebrand Factor - metabolism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFv1DAQhS1ERZfCD-CCIiEhLiljx46dY7UsUKkqEipcLa893k2VxIudILq_HoctLUUgHyyPv_c0M4-QFxROKYB8mygIKkugquSUQbl_RBZUyKpUjNHHZAEZKrlS6pg8Tel6fkJNn5Bj1shG0kouyOevJtmpM7Hdm7ENQxF8MW6xeGd6s0FXXGL8jsU0OIy_6ivv0Y4ztfqxw9j2OIymK5bYdcXVFqPZ3TwjR950CZ_f3ifky_vV1fJjefHpw_ny7KK0XMJYqsYpB2YNjkPD_LquvUFkhjmB0nBWeYA8jEJ0zHnJWGWpqisrGqU4W7vqhLw5-O5i-DZhGnXfJpsbMQOGKWkGXLBaNZXM6Ku_0OswxSF3N1OVgAyJe2pjOtTt4MMYjZ1N9ZngXFAqasjU6T-ofBz2rQ0D-jbXHwhe_yHYounGbQrdNK87PQTpAbQxpBTR611esIk3moKeA9eHwHUOXM-B633WvLydbFr36O4UvxPOADsAKX8NG4z3o__f9SckT7Km</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Petrova, E. S.</creator><creator>Isaeva, E. N.</creator><creator>Kolos, E. A.</creator><creator>Korzhevskii, D. E</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Vascularization of the Damaged Nerve under the Effect of Experimental Cell Therapy</title><author>Petrova, E. S. ; Isaeva, E. N. ; Kolos, E. A. ; Korzhevskii, D. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-89d8d0ab0d4092fb66faee2a2d5e7a423f001578eed2df7223c1863c598842bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood vessels</topic><topic>Cell Biology</topic><topic>Cell- and Tissue-Based Therapy</topic><topic>Endothelial cells</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stromal Cells - physiology</topic><topic>Mesenchyme</topic><topic>Nerve Regeneration - physiology</topic><topic>Pathology</topic><topic>Peripheral Nerve Injuries - metabolism</topic><topic>Peripheral Nerve Injuries - therapy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sciatic nerve</topic><topic>Sciatic Nerve - injuries</topic><topic>Sciatic Nerve - metabolism</topic><topic>Sciatic Nerve - physiology</topic><topic>Spinal cord</topic><topic>Spinal Cord - embryology</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Vascularization</topic><topic>Von Willebrand factor</topic><topic>von Willebrand Factor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrova, E. S.</creatorcontrib><creatorcontrib>Isaeva, E. N.</creatorcontrib><creatorcontrib>Kolos, E. A.</creatorcontrib><creatorcontrib>Korzhevskii, D. E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrova, E. S.</au><au>Isaeva, E. N.</au><au>Kolos, E. A.</au><au>Korzhevskii, D. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascularization of the Damaged Nerve under the Effect of Experimental Cell Therapy</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>165</volume><issue>1</issue><spage>161</spage><epage>165</epage><pages>161-165</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Quantitative analysis of blood vessels in the distal segment of rat sciatic nerve after its ligation for 40 sec and subperineurial administration of mesenchymal stem cells or dissociated cells of rat embryonic spinal cord was carried our by immunohistochemical tracing of von Willebrand factor, a marker of endothelial cells of blood vessels. It was found that the number of blood vessels per unit area of the nerve trunk in 21 days after injury and administration of mesenchymal stem cells increased by more than 1.5 times in comparison with the control (damaged nerve). After administration of dissociated cells of the embryonic spinal cord, this effect was not observed. It is assumed that mesenchymal stem cells stimulate the growth of vessels of the damaged nerve via production of angiogenic factors.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29797137</pmid><doi>10.1007/s10517-018-4120-z</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2018-05, Vol.165 (1), p.161-165 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2045268937 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Angiogenesis Animals Biomedical and Life Sciences Biomedicine Blood vessels Cell Biology Cell- and Tissue-Based Therapy Endothelial cells Immunohistochemistry Internal Medicine Laboratory Medicine Mesenchymal stem cells Mesenchymal Stromal Cells - physiology Mesenchyme Nerve Regeneration - physiology Pathology Peripheral Nerve Injuries - metabolism Peripheral Nerve Injuries - therapy Rats Rats, Wistar Sciatic nerve Sciatic Nerve - injuries Sciatic Nerve - metabolism Sciatic Nerve - physiology Spinal cord Spinal Cord - embryology Stem cell transplantation Stem cells Vascularization Von Willebrand factor von Willebrand Factor - metabolism |
| title | Vascularization of the Damaged Nerve under the Effect of Experimental Cell Therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T00%3A10%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vascularization%20of%20the%20Damaged%20Nerve%20under%20the%20Effect%20of%20Experimental%20Cell%20Therapy&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Petrova,%20E.%20S.&rft.date=2018-05-01&rft.volume=165&rft.issue=1&rft.spage=161&rft.epage=165&rft.pages=161-165&rft.issn=0007-4888&rft.eissn=1573-8221&rft_id=info:doi/10.1007/s10517-018-4120-z&rft_dat=%3Cgale_proqu%3EA544511560%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2043509375&rft_id=info:pmid/29797137&rft_galeid=A544511560&rfr_iscdi=true |