Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation

Phosphoinositide 3-kinase (PI3K) plays an important role in platelet function and contributes to platelet hyperreactivity induced by elevated levels of circulating peptide hormones, including thrombopoietin (TPO). Previous work established an important role for the PI3K isoform; p110β in platelet fu...

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Veröffentlicht in:	Cellular signalling 2018-10, Vol.50, p.111-120
Hauptverfasser:	Blair, T.A., Moore, S.F., Walsh, T.G., Hutchinson, J.L., Durrant, T.N., Anderson, K.E., Poole, A.W., Hers, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - drug effects Blood Platelets - metabolism Blood Platelets - physiology Knockout mice Mice Mice, Knockout p38 Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinase - metabolism Phosphoinositide 3-kinase Phosphorylation - drug effects Phosphorylation - physiology Platelet Activation - drug effects Platelet Activation - physiology Platelet Aggregation - drug effects Platelet Aggregation - physiology Platelets Protein Kinase Inhibitors - pharmacology Signal Transduction - drug effects Signal Transduction - physiology Thrombopoietin Thrombopoietin - metabolism Thrombosis Thrombosis - metabolism Thromboxane A2 - metabolism
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