Multiple functions of short synthetic enantiomeric peptides based on beetle defensins

Four enantiomeric 9-mer peptides, D-peptides A (RLYLRIGRR-NH 2 ), B (RLRLRIGRR-NH 2 ), C (ALYLAIRRR-NH 2 ), and D (RLLLRIGRR-NH 2 ), were designed and synthesized on the basis of a beetle defensin antimicrobial peptide. These D-9-mer peptides have been reported to exhibit multiple functions, includi...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-03, Vol.73 (3), p.683-687
Hauptverfasser:	Iwasaki, T.(Tsukuba Univ., Ibaraki (Japan)), Ishibashi, J, Kubo, M, Taylor, D, Yamakawa, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals antimicrobial peptide ANTIMICROBIAL PROPERTIES Biological and medical sciences BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS Cell Line, Tumor Coleoptera - chemistry DEFENCE MECHANISMS Defensins - chemistry Drug Design FIBROBLASTE FIBROBLASTOS FIBROBLASTS FONCTION PHYSIOLOGIQUE FUNCION FISIOLOGICA Fundamental and applied biological sciences. Psychology Humans Inhibitory Concentration 50 LEUCOCITOS LEUCOCYTE LEUKOCYTES MECANISME DE DEFENSE MECANISMOS DE DEFENSA Membrane Potential, Mitochondrial - drug effects Microscopy, Electron MITOCHONDRIA Mitochondrial Swelling - drug effects MITOCHONDRIE MITOCONDRIA octa-arginine Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - metabolism Oligopeptides - pharmacology PHYSIOLOGICAL FUNCTIONS PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE PROTEINAS PROTEINE PROTEINS PROTOZOA PROTOZOO Rhodamines - chemistry Rhodamines - metabolism Stereoisomerism telomerase Telomerase - antagonists & inhibitors TOXICIDAD TOXICITE TOXICITY
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