Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy
There is still debate over the neural mechanisms underlying pathogenic and even recovery processes of Wernicke's encephalopathy. Therefore, we attempted to validate the usefulness of resting-state functional connectivity analysis in assessing memory function and its neural correlation with the...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 2009-02, Vol.132 (2), p.369-376 |
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| creator | Kim, Eosu Ku, Jeonghun Namkoong, Kee Lee, Wonho Lee, Kang Soo Park, Ji-Yeon Lee, Su Young Kim, Jae-Jin Kim, Sun I. Jung, Young-Chul |
| description | There is still debate over the neural mechanisms underlying pathogenic and even recovery processes of Wernicke's encephalopathy. Therefore, we attempted to validate the usefulness of resting-state functional connectivity analysis in assessing memory function and its neural correlation with the mammillothalamic tract in patients recovering from Wernicke's encephalopathy. Seven chronic alcoholics recovering from Wernicke's encephalopathy, 14 alcoholic comparisons without Wernicke's encephalopathy, and 14 healthy comparisons underwent functional connectivity MRI scans, as well as verbal and non-verbal memory tests after at least a 1 month abstinence from alcohol. Resting-state functional connectivity strength between the anterior thalamus and the mammillary bodies was investigated by calculating temporal correlations in magnetic resonance signal levels between the two regions during a 5-min passive viewing task. The mean values of the functional connectivity strength between the left anterior thalamus and the ipsilateral mammillary body differed significantly between Wernicke's encephalopathy patients and healthy comparisons (P = 0.014). This connectivity strength in alcoholic comparisons fell between those of the former two groups, with a significant difference from that of healthy comparisons (P = 0.038). In addition, the strength of this left-sided functional connectivity significantly correlated with delayed verbal recall scores (r = 0.771, P = 0.042) and verbal recognition score (r = 0.825, P = 0.022) in patients with Wernicke's encephalopathy. Our findings indicate that memory function in patients recovering from Wernicke's encephalopathy parallels the level of the mammillothalamic functional connectivity; this supports the usefulness of resting-state functional connectivity analysis as a practical alternative to pathological examination of the mammillothalamic tract in living patients with Wernicke's encephalopathy. |
| doi_str_mv | 10.1093/brain/awn311 |
| format | Article |
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Therefore, we attempted to validate the usefulness of resting-state functional connectivity analysis in assessing memory function and its neural correlation with the mammillothalamic tract in patients recovering from Wernicke's encephalopathy. Seven chronic alcoholics recovering from Wernicke's encephalopathy, 14 alcoholic comparisons without Wernicke's encephalopathy, and 14 healthy comparisons underwent functional connectivity MRI scans, as well as verbal and non-verbal memory tests after at least a 1 month abstinence from alcohol. Resting-state functional connectivity strength between the anterior thalamus and the mammillary bodies was investigated by calculating temporal correlations in magnetic resonance signal levels between the two regions during a 5-min passive viewing task. The mean values of the functional connectivity strength between the left anterior thalamus and the ipsilateral mammillary body differed significantly between Wernicke's encephalopathy patients and healthy comparisons (P = 0.014). This connectivity strength in alcoholic comparisons fell between those of the former two groups, with a significant difference from that of healthy comparisons (P = 0.038). In addition, the strength of this left-sided functional connectivity significantly correlated with delayed verbal recall scores (r = 0.771, P = 0.042) and verbal recognition score (r = 0.825, P = 0.022) in patients with Wernicke's encephalopathy. Our findings indicate that memory function in patients recovering from Wernicke's encephalopathy parallels the level of the mammillothalamic functional connectivity; this supports the usefulness of resting-state functional connectivity analysis as a practical alternative to pathological examination of the mammillothalamic tract in living patients with Wernicke's encephalopathy.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/awn311</identifier><identifier>PMID: 19036763</identifier><identifier>CODEN: BRAIAK</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Alcoholism - pathology ; Alcoholism - physiopathology ; Anterior Thalamic Nuclei - pathology ; Anterior Thalamic Nuclei - physiopathology ; Biological and medical sciences ; Brain - pathology ; Brain - physiopathology ; Case-Control Studies ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Mammillary Bodies - pathology ; Mammillary Bodies - physiopathology ; mammillothalamic tract ; Medical sciences ; memory ; Memory - physiology ; Middle Aged ; Nervous system ; Neural Pathways - physiology ; Neurology ; Neuropsychological Tests ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; resting-state functional connectivity ; Thiamine - therapeutic use ; Vitamin B Complex - therapeutic use ; Wernicke Encephalopathy - drug therapy ; Wernicke Encephalopathy - pathology ; Wernicke Encephalopathy - physiopathology ; Wernicke's encephalopathy</subject><ispartof>Brain (London, England : 1878), 2009-02, Vol.132 (2), p.369-376</ispartof><rights>The Author (2008). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2008</rights><rights>2009 INIST-CNRS</rights><rights>The Author (2008). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-19d35e338906c804d916e15a2e9351b9ffdf266d5c52ba3ad20cf6d8372ba2c03</citedby><cites>FETCH-LOGICAL-c447t-19d35e338906c804d916e15a2e9351b9ffdf266d5c52ba3ad20cf6d8372ba2c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21127138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19036763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Eosu</creatorcontrib><creatorcontrib>Ku, Jeonghun</creatorcontrib><creatorcontrib>Namkoong, Kee</creatorcontrib><creatorcontrib>Lee, Wonho</creatorcontrib><creatorcontrib>Lee, Kang Soo</creatorcontrib><creatorcontrib>Park, Ji-Yeon</creatorcontrib><creatorcontrib>Lee, Su Young</creatorcontrib><creatorcontrib>Kim, Jae-Jin</creatorcontrib><creatorcontrib>Kim, Sun I.</creatorcontrib><creatorcontrib>Jung, Young-Chul</creatorcontrib><title>Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>There is still debate over the neural mechanisms underlying pathogenic and even recovery processes of Wernicke's encephalopathy. Therefore, we attempted to validate the usefulness of resting-state functional connectivity analysis in assessing memory function and its neural correlation with the mammillothalamic tract in patients recovering from Wernicke's encephalopathy. Seven chronic alcoholics recovering from Wernicke's encephalopathy, 14 alcoholic comparisons without Wernicke's encephalopathy, and 14 healthy comparisons underwent functional connectivity MRI scans, as well as verbal and non-verbal memory tests after at least a 1 month abstinence from alcohol. Resting-state functional connectivity strength between the anterior thalamus and the mammillary bodies was investigated by calculating temporal correlations in magnetic resonance signal levels between the two regions during a 5-min passive viewing task. The mean values of the functional connectivity strength between the left anterior thalamus and the ipsilateral mammillary body differed significantly between Wernicke's encephalopathy patients and healthy comparisons (P = 0.014). This connectivity strength in alcoholic comparisons fell between those of the former two groups, with a significant difference from that of healthy comparisons (P = 0.038). In addition, the strength of this left-sided functional connectivity significantly correlated with delayed verbal recall scores (r = 0.771, P = 0.042) and verbal recognition score (r = 0.825, P = 0.022) in patients with Wernicke's encephalopathy. Our findings indicate that memory function in patients recovering from Wernicke's encephalopathy parallels the level of the mammillothalamic functional connectivity; this supports the usefulness of resting-state functional connectivity analysis as a practical alternative to pathological examination of the mammillothalamic tract in living patients with Wernicke's encephalopathy.</description><subject>Adult</subject><subject>Alcoholism - pathology</subject><subject>Alcoholism - physiopathology</subject><subject>Anterior Thalamic Nuclei - pathology</subject><subject>Anterior Thalamic Nuclei - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Case-Control Studies</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Mammillary Bodies - pathology</subject><subject>Mammillary Bodies - physiopathology</subject><subject>mammillothalamic tract</subject><subject>Medical sciences</subject><subject>memory</subject><subject>Memory - physiology</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neural Pathways - physiology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>resting-state functional connectivity</subject><subject>Thiamine - therapeutic use</subject><subject>Vitamin B Complex - therapeutic use</subject><subject>Wernicke Encephalopathy - drug therapy</subject><subject>Wernicke Encephalopathy - pathology</subject><subject>Wernicke Encephalopathy - physiopathology</subject><subject>Wernicke's encephalopathy</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1v1DAQBmALgehSuHFGERL0QqjHjp34WBX6RRESKuLjYs06juo2sYOdAPvva8hqkbhwGo306B3NS8hToK-BKn64juj8If70HOAeWUElaclAyPtkRSmVZaME3SOPUrqhFCrO5EOyB4pyWUu-Il_f4zC4vg_TNfY4OFN0szeTCx77wgTvbV5-uGlToG-LwQ4hbnakcL74bKN35tYepMJ6Y8ccE0acrjePyYMO-2SfbOc--XTy9ur4rLz8cHp-fHRZmqqqpxJUy4XlvFFUmoZWrQJpQSCzigtYq65rOyZlK4xga-TYMmo62Ta8ziszlO-Tl0vuGMP32aZJDy4Z2_fobZiTZrQSlCmW4fN_4E2YY_4zaVCiqrhkMqNXCzIxpBRtp8foBowbDVT_7lv_6VsvfWf-bJs5rwfb_sXbgjN4sQWYDPZdRG9c2jkGwGrgTXYHiwvz-L-T5SJdmuyvncV4q2XNa6HPvnzTJ8DF1Zt3H_UFvwPlmKdV</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Kim, Eosu</creator><creator>Ku, Jeonghun</creator><creator>Namkoong, Kee</creator><creator>Lee, Wonho</creator><creator>Lee, Kang Soo</creator><creator>Park, Ji-Yeon</creator><creator>Lee, Su Young</creator><creator>Kim, Jae-Jin</creator><creator>Kim, Sun I.</creator><creator>Jung, Young-Chul</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20090201</creationdate><title>Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy</title><author>Kim, Eosu ; Ku, Jeonghun ; Namkoong, Kee ; Lee, Wonho ; Lee, Kang Soo ; Park, Ji-Yeon ; Lee, Su Young ; Kim, Jae-Jin ; Kim, Sun I. ; Jung, Young-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-19d35e338906c804d916e15a2e9351b9ffdf266d5c52ba3ad20cf6d8372ba2c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Alcoholism - pathology</topic><topic>Alcoholism - physiopathology</topic><topic>Anterior Thalamic Nuclei - pathology</topic><topic>Anterior Thalamic Nuclei - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Case-Control Studies</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Mammillary Bodies - pathology</topic><topic>Mammillary Bodies - physiopathology</topic><topic>mammillothalamic tract</topic><topic>Medical sciences</topic><topic>memory</topic><topic>Memory - physiology</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neural Pathways - physiology</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>resting-state functional connectivity</topic><topic>Thiamine - therapeutic use</topic><topic>Vitamin B Complex - therapeutic use</topic><topic>Wernicke Encephalopathy - drug therapy</topic><topic>Wernicke Encephalopathy - pathology</topic><topic>Wernicke Encephalopathy - physiopathology</topic><topic>Wernicke's encephalopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Eosu</creatorcontrib><creatorcontrib>Ku, Jeonghun</creatorcontrib><creatorcontrib>Namkoong, Kee</creatorcontrib><creatorcontrib>Lee, Wonho</creatorcontrib><creatorcontrib>Lee, Kang Soo</creatorcontrib><creatorcontrib>Park, Ji-Yeon</creatorcontrib><creatorcontrib>Lee, Su Young</creatorcontrib><creatorcontrib>Kim, Jae-Jin</creatorcontrib><creatorcontrib>Kim, Sun I.</creatorcontrib><creatorcontrib>Jung, Young-Chul</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Eosu</au><au>Ku, Jeonghun</au><au>Namkoong, Kee</au><au>Lee, Wonho</au><au>Lee, Kang Soo</au><au>Park, Ji-Yeon</au><au>Lee, Su Young</au><au>Kim, Jae-Jin</au><au>Kim, Sun I.</au><au>Jung, Young-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>132</volume><issue>2</issue><spage>369</spage><epage>376</epage><pages>369-376</pages><issn>0006-8950</issn><eissn>1460-2156</eissn><coden>BRAIAK</coden><abstract>There is still debate over the neural mechanisms underlying pathogenic and even recovery processes of Wernicke's encephalopathy. Therefore, we attempted to validate the usefulness of resting-state functional connectivity analysis in assessing memory function and its neural correlation with the mammillothalamic tract in patients recovering from Wernicke's encephalopathy. Seven chronic alcoholics recovering from Wernicke's encephalopathy, 14 alcoholic comparisons without Wernicke's encephalopathy, and 14 healthy comparisons underwent functional connectivity MRI scans, as well as verbal and non-verbal memory tests after at least a 1 month abstinence from alcohol. Resting-state functional connectivity strength between the anterior thalamus and the mammillary bodies was investigated by calculating temporal correlations in magnetic resonance signal levels between the two regions during a 5-min passive viewing task. The mean values of the functional connectivity strength between the left anterior thalamus and the ipsilateral mammillary body differed significantly between Wernicke's encephalopathy patients and healthy comparisons (P = 0.014). This connectivity strength in alcoholic comparisons fell between those of the former two groups, with a significant difference from that of healthy comparisons (P = 0.038). In addition, the strength of this left-sided functional connectivity significantly correlated with delayed verbal recall scores (r = 0.771, P = 0.042) and verbal recognition score (r = 0.825, P = 0.022) in patients with Wernicke's encephalopathy. Our findings indicate that memory function in patients recovering from Wernicke's encephalopathy parallels the level of the mammillothalamic functional connectivity; this supports the usefulness of resting-state functional connectivity analysis as a practical alternative to pathological examination of the mammillothalamic tract in living patients with Wernicke's encephalopathy.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>19036763</pmid><doi>10.1093/brain/awn311</doi><tpages>8</tpages></addata></record> |
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| ispartof | Brain (London, England : 1878), 2009-02, Vol.132 (2), p.369-376 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Alcoholism - pathology Alcoholism - physiopathology Anterior Thalamic Nuclei - pathology Anterior Thalamic Nuclei - physiopathology Biological and medical sciences Brain - pathology Brain - physiopathology Case-Control Studies Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Mammillary Bodies - pathology Mammillary Bodies - physiopathology mammillothalamic tract Medical sciences memory Memory - physiology Middle Aged Nervous system Neural Pathways - physiology Neurology Neuropsychological Tests Radiodiagnosis. Nmr imagery. Nmr spectrometry resting-state functional connectivity Thiamine - therapeutic use Vitamin B Complex - therapeutic use Wernicke Encephalopathy - drug therapy Wernicke Encephalopathy - pathology Wernicke Encephalopathy - physiopathology Wernicke's encephalopathy |
| title | Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy |
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