Efficacy and safety of replacing lopinavir with atazanavir in HIV-infected patients with undetectable plasma viraemia: final results of the SLOAT trial

Background Atazanavir seems to be a protease inhibitor (PI) with a more favourable metabolic profile. Information regarding the potential benefit of replacing lopinavir/ritonavir by atazanavir in HIV-infected patients with prolonged viral suppression is scarce. If proved, this strategy could be part...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2008-01, Vol.61 (1), p.200-205
Hauptverfasser:	Soriano, Vincent, García-Gasco, Pilar, Vispo, Eugenia, Ruiz-Sancho, Andrés, Blanco, Francisco, Martín-Carbonero, Luz, Rodríguez-Novoa, Sonia, Morello, Judit, de Mendoza, Carmen, Rivas, Pablo, Barreiro, Pablo, González-Lahoz, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibiotics. Antiinfectious agents. Antiparasitic agents antiretroviral therapy Antiretroviral Therapy, Highly Active Atazanavir Sulfate Biological and medical sciences Blood Glucose - analysis Cardiovascular disease CD4 Lymphocyte Count Comparative studies Drug Administration Schedule drug resistance dyslipidaemia Female Follow-Up Studies HIV HIV Infections - blood HIV Infections - drug therapy HIV Infections - virology HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - adverse effects HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - isolation & purification Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lipids - blood Lopinavir Male Medical sciences Metabolic diseases metabolic syndrome Metabolism Microbiology Middle Aged Miscellaneous Oligopeptides - administration & dosage Oligopeptides - adverse effects Oligopeptides - therapeutic use Other metabolic disorders Pharmacology. Drug treatments Prospective Studies Protease inhibitors Pyridines - administration & dosage Pyridines - adverse effects Pyridines - therapeutic use Pyrimidinones - administration & dosage Pyrimidinones - adverse effects Pyrimidinones - therapeutic use Risk factors RNA, Viral - blood simplification strategies Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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