Expression levels of 63 p53-related genes add up to similar values in 24 different tissues and are unified in cancer
The expression patterns of 62 genes interacting with p53 have been investigated in 24 normal and cancerous tissues using NIH's dbEST library. The expression levels of individual genes, such as the T TP53 gene itself, but also other genes, vary up to 33-fold among the 24 different tissues and no...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 2007-12, Vol.90 (6), p.661-673 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Altenberg, B. Rapp, A. Schmitt, E. Greulich, K.O. |
| description | The expression patterns of 62 genes interacting with p53 have been investigated in 24 normal and cancerous tissues using NIH's dbEST library. The expression levels of individual genes, such as the T
TP53 gene itself, but also other genes, vary up to 33-fold among the 24 different tissues and no consistent pattern can be recognized. However, when expression levels for all 63 genes are summed, these “cumulated levels” are surprisingly constant over the 24 investigated normal tissues. In cancers, the variation is further reduced. Essentially, the cumulated expression levels in cancer are independent of those in normal tissue. We furthermore constructed a linear statistical classifier, i.e., a
weighted sum of gene expression levels, which robustly distinguishes normal from cancer tissue independent of the particular kind of tissue. Thus, despite very large differences for individual genes and considerable changes during carcinogenesis, the cumulated expressions have narrowly defined levels. |
| doi_str_mv | 10.1016/j.ygeno.2007.06.005 |
| format | Article |
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weighted sum of gene expression levels, which robustly distinguishes normal from cancer tissue independent of the particular kind of tissue. Thus, despite very large differences for individual genes and considerable changes during carcinogenesis, the cumulated expressions have narrowly defined levels.</description><subject>Biological and medical sciences</subject><subject>Cancer genes</subject><subject>Data mining</subject><subject>Databases, Genetic</subject><subject>dbEST database</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Profiling</subject><subject>Genes, p53</subject><subject>Genes, Tumor Suppressor</subject><subject>Genes. Genome</subject><subject>Genetics of eukaryotes. 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Biological and molecular evolution</topic><topic>Humans</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Neoplasms - genetics</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oncogenes</topic><topic>Pregnancy</topic><topic>Statistical classifier</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altenberg, B.</creatorcontrib><creatorcontrib>Rapp, A.</creatorcontrib><creatorcontrib>Schmitt, E.</creatorcontrib><creatorcontrib>Greulich, K.O.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altenberg, B.</au><au>Rapp, A.</au><au>Schmitt, E.</au><au>Greulich, K.O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression levels of 63 p53-related genes add up to similar values in 24 different tissues and are unified in cancer</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>90</volume><issue>6</issue><spage>661</spage><epage>673</epage><pages>661-673</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The expression patterns of 62 genes interacting with p53 have been investigated in 24 normal and cancerous tissues using NIH's dbEST library. 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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Cancer genes Data mining Databases, Genetic dbEST database Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Genes, p53 Genes, Tumor Suppressor Genes. Genome Genetics of eukaryotes. Biological and molecular evolution Humans Male Molecular and cellular biology Molecular genetics Neoplasms - genetics Oligonucleotide Array Sequence Analysis Oncogenes Pregnancy Statistical classifier Tissue Distribution |
| title | Expression levels of 63 p53-related genes add up to similar values in 24 different tissues and are unified in cancer |
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