Strain-dependent acute lung injury after intra-tracheal administration of a ‘refined’ aniline-denatured rapeseed oil: A murine model of the toxic oil syndrome?

Most attempts to reproduce the toxic oil syndrome in animals, either with case-related oils or with refined rapeseed oils, have been unsuccessful. An aniline-denatured rapeseed oil that was subsequently refined according to a protocol yielding relevant markers of “toxic oil” (oil RSO160401) had led...

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Veröffentlicht in:	Food and chemical toxicology 2007-12, Vol.45 (12), p.2563-2573
Hauptverfasser:	Vanhooren, Hadewijch M., Vanoirbeek, Jeroen A., Xu, Haiyan, Verbeken, Erik, Nemery, Benoit
Format:	Artikel
Sprache:	eng
Schlagworte:	acute effects Acute phase pathology acute pulmonary damage aniline Aniline Compounds - administration & dosage Aniline Compounds - toxicity Animals Biological and medical sciences Canola Oil dietary exposure Disease Models, Animal Eosinophilia Eosinophilia-Myalgia Syndrome - chemically induced Eosinophilia-Myalgia Syndrome - diagnosis Fatty Acids, Monounsaturated Female Humans intra-trachael administration Intra-tracheal administration intragastric administration lesions (animal) lungs Medical sciences Mice Mice, Inbred Strains - classification Murine model Plant Oils - administration & dosage Plant Oils - toxicity rapeseed oil refining Respiratory Distress Syndrome, Adult - chemically induced Respiratory Distress Syndrome, Adult - diagnosis Toxic oil syndrome toxic substances toxicity testing Toxicology Trachea
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