Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats

The peptide neurotransmitter N‐acetylaspartylglutamate (NAAG) selectively activates group II metabotropic glutamate receptors (mGluRs). Systemic administration of inhibitors of the enzymes that inactivate NAAG results in decreased pain responses in rat models of inflammatory and neuropathic pain. Th...

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Veröffentlicht in:	The European journal of neuroscience 2007-01, Vol.25 (1), p.147-158
Hauptverfasser:	Yamamoto, Tatsuo, Saito, Osamu, Aoe, Tomohiko, Bartolozzi, Alessandra, Sarva, Jayaprakash, Zhou, Jia, Kozikowski, Alan, Wroblewska, Barbara, Bzdega, Tomasz, Neale, Joseph H.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology Animals Carrageenan Cells, Cultured Cerebellum - cytology Cricetinae Cricetulus Drug Interactions Excitatory Amino Acid Agents - pharmacology Formaldehyde - adverse effects Functional Laterality Glutamate Carboxypeptidase II - antagonists & inhibitors group II mGluRs inflammatory pain LY 341495 NAAG Neuralgia - chemically induced Neuralgia - drug therapy Neuralgia - physiopathology Neurons - drug effects Organophosphorus Compounds - administration & dosage Pain Measurement - methods Pain Threshold - drug effects Phosphodiesterase Inhibitors - pharmacology Rats Rats, Sprague-Dawley Reaction Time - drug effects Receptors, Glutamate - physiology sensory neurons Transfection - methods Urea - administration & dosage Urea - analogs & derivatives
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