Bidirectional Synthesis of Di-tert-butyl (2S,6S,8S)- and (2R,6R,8R)‑1,7-Diazaspiro­[5.5]­undecane-2,8-dicarboxylate and Related Spirodiamines

Efficient syntheses of both enantiomers of a spirodiamine diester from (l)- and (d)-aspartic acid are described. The key transformation was the conversion of Boc-protected tert-butyl aspartate into the derived aldehyde, two-directional Horner–Wadsworth–Emmons olefination, hydrogenation, and selectiv...

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Veröffentlicht in:	Journal of organic chemistry 2018-06, Vol.83 (12), p.6783-6787
Hauptverfasser:	Almond-Thynne, Joshua, Han, Jiaxu, White, Andrew J. P, Polyzos, Anastasios, Parsons, Philip J, Barrett, Anthony G. M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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