Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance

•Exemestane induces cytoprotective autophagy in resistant breast cancer cells.•Targeting autophagy and PI3K pathway re-sensitise resistant breast cancer cells to Exemestane.•Autophagy is an attractive therapeutic target to surpass Exemestane-acquired resistance. The leading cause of cancer death in...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2018-10, Vol.183, p.51-61
Hauptverfasser:	Amaral, Cristina, Augusto, Tiago Vieira, Tavares-da-Silva, Elisiário, Roleira, Fernanda M.F., Correia-da-Silva, Georgina, Teixeira, Natércia
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acquired resistance AKT protein Androstadienes - pharmacology Apoptosis Aromatase Aromatase - chemistry Aromatase inhibitors Aromatase Inhibitors - pharmacology Autophagy Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Cycle Cell death Cell Proliferation Cell survival Drug Resistance, Neoplasm Estrogen receptors Estrogens Exemestane Female Gene Expression Regulation, Neoplastic - drug effects Humans Mortality Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Phagocytosis Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism PI3K pathway Post-menopause Therapeutic applications TOR protein Tumor Cells, Cultured Tumors Women
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