Morbidity in former sawmill workers exposed to pentachlorophenol (PCP): A cross-sectional study in New Zealand
Background From 1950 to 1990 pentachlorophenol (PCP) was used widely in the New Zealand sawmill industry, and persistent claims of long‐term health effects have been made. Methods We surveyed surviving members of a cohort enumerated to study mortality in sawmill workers employed from 1970 to 1990. E...
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| Veröffentlicht in: | American journal of industrial medicine 2009-04, Vol.52 (4), p.271-281 |
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| container_title | American journal of industrial medicine |
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| creator | McLean, David Eng, Amanda Dryson, Evan Walls, Chris Harding, Elizabeth Wong, Khoon Ching Cheng, Soo Mannetje, Andrea't Ellison-Loschmann, Lis Slater, Tania Shoemack, Phil Pearce, Neil |
| description | Background
From 1950 to 1990 pentachlorophenol (PCP) was used widely in the New Zealand sawmill industry, and persistent claims of long‐term health effects have been made.
Methods
We surveyed surviving members of a cohort enumerated to study mortality in sawmill workers employed from 1970 to 1990. Estimates of historical exposure were based on job titles held, using the results of a PCP biomonitoring survey conducted in the 1980s. The survey involved interviews and clinical examinations, with interviewers and examiners blinded to exposure status.
Results
Of the 293 participants 177 had not been exposed, and of the 116 exposed all but 10% had low or short‐term PCP exposure. Nevertheless, a number of significant associations between PCP exposure and the prevalence of various symptoms were observed including associations between: (i) exposure levels and self‐reported tuberculosis, pleurisy or pneumonia (P |
| doi_str_mv | 10.1002/ajim.20677 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20434487</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20434487</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4267-4dcc873cdb6c1b379fefad1487341cb184a81a0010dde55a3d42e8b67358f16e3</originalsourceid><addsrcrecordid>eNp9kEtv1DAUhS0EotOBDT8AeQMCpBS_EmfYjaZQitpSFVClbizHvlHdOnGwM5rOv8fzoOxYXenqO-fecxB6RckRJYR91HeuO2KkkvIJmlAykwVhUjxFkzxowcu6OkCHKd0RQqmoxHN0QGe0ZLwsJ6g_D7Fx1o1r7HrchthBxEmvOuc9XoV4DzFheBhCAovHgAfoR21ufYhhuIU-ePzucnH5_hOeYxNDSkUCM7rQa4_TuLRb1wtY4RvQXvf2BXrWap_g5X5O0a8vn38uvhZn309OF_OzwghWyUJYY2rJjW0qQxsuZy202lKRd4KahtZC11TnPMRaKEvNrWBQN5XMYVtaAZ-itzvfIYbfS0ij6lwy4PMPEJZJMSK42NhN0YcduP0-QquG6Dod14oStWlXbdpV23Yz_Hrvumw6sP_QfZ0ZeLMHdDLat1H3xqVHjtEcjpQ8c3THrZyH9X9Oqvm30_O_x4udxqURHh41Ot6rnFuW6vriRF3f_DgWgl2pK_4HUu6hzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20434487</pqid></control><display><type>article</type><title>Morbidity in former sawmill workers exposed to pentachlorophenol (PCP): A cross-sectional study in New Zealand</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>McLean, David ; Eng, Amanda ; Dryson, Evan ; Walls, Chris ; Harding, Elizabeth ; Wong, Khoon Ching ; Cheng, Soo ; Mannetje, Andrea't ; Ellison-Loschmann, Lis ; Slater, Tania ; Shoemack, Phil ; Pearce, Neil</creator><creatorcontrib>McLean, David ; Eng, Amanda ; Dryson, Evan ; Walls, Chris ; Harding, Elizabeth ; Wong, Khoon Ching ; Cheng, Soo ; Mannetje, Andrea't ; Ellison-Loschmann, Lis ; Slater, Tania ; Shoemack, Phil ; Pearce, Neil</creatorcontrib><description>Background
From 1950 to 1990 pentachlorophenol (PCP) was used widely in the New Zealand sawmill industry, and persistent claims of long‐term health effects have been made.
Methods
We surveyed surviving members of a cohort enumerated to study mortality in sawmill workers employed from 1970 to 1990. Estimates of historical exposure were based on job titles held, using the results of a PCP biomonitoring survey conducted in the 1980s. The survey involved interviews and clinical examinations, with interviewers and examiners blinded to exposure status.
Results
Of the 293 participants 177 had not been exposed, and of the 116 exposed all but 10% had low or short‐term PCP exposure. Nevertheless, a number of significant associations between PCP exposure and the prevalence of various symptoms were observed including associations between: (i) exposure levels and self‐reported tuberculosis, pleurisy or pneumonia (P < 0.01) and a deficit in cranial nerve function (P = 0.04); (ii) duration of employment and thyroid disorders (P = 0.04), and neuropsychological symptoms including often going back to check things (P = 0.04), low libido (P = 0.02) and heart palpitations (P = 0.02), and a strong dose–response trend for frequent mood changes without cause (P < 0.01); and (iii) cumulative exposure and frequent mood changes without cause (P = 0.02), low libido (P = 0.04), and in the overall number of neuropsychological symptoms reported (P = 0.03).
Conclusions
PCP exposure was associated with a number of physical and neuropsychological health effects that persisted long after exposure had ceased. Am. J. Ind. Med. 52:271–281, 2009. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.20677</identifier><identifier>PMID: 19152355</identifier><identifier>CODEN: AJIMD8</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cross-Sectional Studies ; Drug addictions ; Female ; Humans ; Interviews as Topic ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; morbidity ; Mycobacterium ; New Zealand - epidemiology ; Occupational Diseases - epidemiology ; Occupational Exposure - adverse effects ; pentachlorophenol ; Pentachlorophenol - poisoning ; sawmill workers ; Toxicology</subject><ispartof>American journal of industrial medicine, 2009-04, Vol.52 (4), p.271-281</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4267-4dcc873cdb6c1b379fefad1487341cb184a81a0010dde55a3d42e8b67358f16e3</citedby><cites>FETCH-LOGICAL-c4267-4dcc873cdb6c1b379fefad1487341cb184a81a0010dde55a3d42e8b67358f16e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajim.20677$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajim.20677$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21267053$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19152355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McLean, David</creatorcontrib><creatorcontrib>Eng, Amanda</creatorcontrib><creatorcontrib>Dryson, Evan</creatorcontrib><creatorcontrib>Walls, Chris</creatorcontrib><creatorcontrib>Harding, Elizabeth</creatorcontrib><creatorcontrib>Wong, Khoon Ching</creatorcontrib><creatorcontrib>Cheng, Soo</creatorcontrib><creatorcontrib>Mannetje, Andrea't</creatorcontrib><creatorcontrib>Ellison-Loschmann, Lis</creatorcontrib><creatorcontrib>Slater, Tania</creatorcontrib><creatorcontrib>Shoemack, Phil</creatorcontrib><creatorcontrib>Pearce, Neil</creatorcontrib><title>Morbidity in former sawmill workers exposed to pentachlorophenol (PCP): A cross-sectional study in New Zealand</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Background
From 1950 to 1990 pentachlorophenol (PCP) was used widely in the New Zealand sawmill industry, and persistent claims of long‐term health effects have been made.
Methods
We surveyed surviving members of a cohort enumerated to study mortality in sawmill workers employed from 1970 to 1990. Estimates of historical exposure were based on job titles held, using the results of a PCP biomonitoring survey conducted in the 1980s. The survey involved interviews and clinical examinations, with interviewers and examiners blinded to exposure status.
Results
Of the 293 participants 177 had not been exposed, and of the 116 exposed all but 10% had low or short‐term PCP exposure. Nevertheless, a number of significant associations between PCP exposure and the prevalence of various symptoms were observed including associations between: (i) exposure levels and self‐reported tuberculosis, pleurisy or pneumonia (P < 0.01) and a deficit in cranial nerve function (P = 0.04); (ii) duration of employment and thyroid disorders (P = 0.04), and neuropsychological symptoms including often going back to check things (P = 0.04), low libido (P = 0.02) and heart palpitations (P = 0.02), and a strong dose–response trend for frequent mood changes without cause (P < 0.01); and (iii) cumulative exposure and frequent mood changes without cause (P = 0.02), low libido (P = 0.04), and in the overall number of neuropsychological symptoms reported (P = 0.03).
Conclusions
PCP exposure was associated with a number of physical and neuropsychological health effects that persisted long after exposure had ceased. Am. J. Ind. Med. 52:271–281, 2009. © 2009 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Drug addictions</subject><subject>Female</subject><subject>Humans</subject><subject>Interviews as Topic</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>morbidity</subject><subject>Mycobacterium</subject><subject>New Zealand - epidemiology</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Exposure - adverse effects</subject><subject>pentachlorophenol</subject><subject>Pentachlorophenol - poisoning</subject><subject>sawmill workers</subject><subject>Toxicology</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1DAUhS0EotOBDT8AeQMCpBS_EmfYjaZQitpSFVClbizHvlHdOnGwM5rOv8fzoOxYXenqO-fecxB6RckRJYR91HeuO2KkkvIJmlAykwVhUjxFkzxowcu6OkCHKd0RQqmoxHN0QGe0ZLwsJ6g_D7Fx1o1r7HrchthBxEmvOuc9XoV4DzFheBhCAovHgAfoR21ufYhhuIU-ePzucnH5_hOeYxNDSkUCM7rQa4_TuLRb1wtY4RvQXvf2BXrWap_g5X5O0a8vn38uvhZn309OF_OzwghWyUJYY2rJjW0qQxsuZy202lKRd4KahtZC11TnPMRaKEvNrWBQN5XMYVtaAZ-itzvfIYbfS0ij6lwy4PMPEJZJMSK42NhN0YcduP0-QquG6Dod14oStWlXbdpV23Yz_Hrvumw6sP_QfZ0ZeLMHdDLat1H3xqVHjtEcjpQ8c3THrZyH9X9Oqvm30_O_x4udxqURHh41Ot6rnFuW6vriRF3f_DgWgl2pK_4HUu6hzw</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>McLean, David</creator><creator>Eng, Amanda</creator><creator>Dryson, Evan</creator><creator>Walls, Chris</creator><creator>Harding, Elizabeth</creator><creator>Wong, Khoon Ching</creator><creator>Cheng, Soo</creator><creator>Mannetje, Andrea't</creator><creator>Ellison-Loschmann, Lis</creator><creator>Slater, Tania</creator><creator>Shoemack, Phil</creator><creator>Pearce, Neil</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>200904</creationdate><title>Morbidity in former sawmill workers exposed to pentachlorophenol (PCP): A cross-sectional study in New Zealand</title><author>McLean, David ; Eng, Amanda ; Dryson, Evan ; Walls, Chris ; Harding, Elizabeth ; Wong, Khoon Ching ; Cheng, Soo ; Mannetje, Andrea't ; Ellison-Loschmann, Lis ; Slater, Tania ; Shoemack, Phil ; Pearce, Neil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4267-4dcc873cdb6c1b379fefad1487341cb184a81a0010dde55a3d42e8b67358f16e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Drug addictions</topic><topic>Female</topic><topic>Humans</topic><topic>Interviews as Topic</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>morbidity</topic><topic>Mycobacterium</topic><topic>New Zealand - epidemiology</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Exposure - adverse effects</topic><topic>pentachlorophenol</topic><topic>Pentachlorophenol - poisoning</topic><topic>sawmill workers</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McLean, David</creatorcontrib><creatorcontrib>Eng, Amanda</creatorcontrib><creatorcontrib>Dryson, Evan</creatorcontrib><creatorcontrib>Walls, Chris</creatorcontrib><creatorcontrib>Harding, Elizabeth</creatorcontrib><creatorcontrib>Wong, Khoon Ching</creatorcontrib><creatorcontrib>Cheng, Soo</creatorcontrib><creatorcontrib>Mannetje, Andrea't</creatorcontrib><creatorcontrib>Ellison-Loschmann, Lis</creatorcontrib><creatorcontrib>Slater, Tania</creatorcontrib><creatorcontrib>Shoemack, Phil</creatorcontrib><creatorcontrib>Pearce, Neil</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McLean, David</au><au>Eng, Amanda</au><au>Dryson, Evan</au><au>Walls, Chris</au><au>Harding, Elizabeth</au><au>Wong, Khoon Ching</au><au>Cheng, Soo</au><au>Mannetje, Andrea't</au><au>Ellison-Loschmann, Lis</au><au>Slater, Tania</au><au>Shoemack, Phil</au><au>Pearce, Neil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morbidity in former sawmill workers exposed to pentachlorophenol (PCP): A cross-sectional study in New Zealand</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>2009-04</date><risdate>2009</risdate><volume>52</volume><issue>4</issue><spage>271</spage><epage>281</epage><pages>271-281</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><coden>AJIMD8</coden><abstract>Background
From 1950 to 1990 pentachlorophenol (PCP) was used widely in the New Zealand sawmill industry, and persistent claims of long‐term health effects have been made.
Methods
We surveyed surviving members of a cohort enumerated to study mortality in sawmill workers employed from 1970 to 1990. Estimates of historical exposure were based on job titles held, using the results of a PCP biomonitoring survey conducted in the 1980s. The survey involved interviews and clinical examinations, with interviewers and examiners blinded to exposure status.
Results
Of the 293 participants 177 had not been exposed, and of the 116 exposed all but 10% had low or short‐term PCP exposure. Nevertheless, a number of significant associations between PCP exposure and the prevalence of various symptoms were observed including associations between: (i) exposure levels and self‐reported tuberculosis, pleurisy or pneumonia (P < 0.01) and a deficit in cranial nerve function (P = 0.04); (ii) duration of employment and thyroid disorders (P = 0.04), and neuropsychological symptoms including often going back to check things (P = 0.04), low libido (P = 0.02) and heart palpitations (P = 0.02), and a strong dose–response trend for frequent mood changes without cause (P < 0.01); and (iii) cumulative exposure and frequent mood changes without cause (P = 0.02), low libido (P = 0.04), and in the overall number of neuropsychological symptoms reported (P = 0.03).
Conclusions
PCP exposure was associated with a number of physical and neuropsychological health effects that persisted long after exposure had ceased. Am. J. Ind. Med. 52:271–281, 2009. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19152355</pmid><doi>10.1002/ajim.20677</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Biological and medical sciences Cross-Sectional Studies Drug addictions Female Humans Interviews as Topic Logistic Models Male Medical sciences Middle Aged morbidity Mycobacterium New Zealand - epidemiology Occupational Diseases - epidemiology Occupational Exposure - adverse effects pentachlorophenol Pentachlorophenol - poisoning sawmill workers Toxicology |
| title | Morbidity in former sawmill workers exposed to pentachlorophenol (PCP): A cross-sectional study in New Zealand |
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