Unexpected Inhibition of Peptidoglycan LD-Transpeptidase from Enterococcus faecium by the β-Lactam Imipenem

The β-lactam antibiotics mimic the d-alanyl4-d-alanine5 extremity of peptidoglycan precursors and act as “suicide” substrates of the dd-transpeptidases that catalyze the last cross-linking step of peptidoglycan synthesis. We have previously shown that bypass of the dd-transpeptidases by the ld-trans...

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Veröffentlicht in:	The Journal of biological chemistry 2007-10, Vol.282 (42), p.30414-30422
Hauptverfasser:	Mainardi, Jean-Luc, Hugonnet, Jean-Emmanuel, Rusconi, Filippo, Fourgeaud, Martine, Dubost, Lionel, Moumi, Angèle Nguekam, Delfosse, Vanessa, Mayer, Claudine, Gutmann, Laurent, Rice, Louis B., Arthur, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation - drug effects Aminoacyltransferases - antagonists & inhibitors Aminoacyltransferases - chemistry Aminoacyltransferases - metabolism Ampicillin - chemistry Ampicillin - pharmacology Ampicillin - therapeutic use Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - metabolism beta-Lactams - chemistry beta-Lactams - pharmacology beta-Lactams - therapeutic use Dipeptides - chemistry Dipeptides - metabolism Dose-Response Relationship, Drug Enterococcus faecium Enterococcus faecium - enzymology Enterococcus faecium - growth & development Enzyme Precursors - antagonists & inhibitors Enzyme Precursors - chemistry Enzyme Precursors - pharmacology Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - enzymology Imipenem - chemistry Imipenem - pharmacology Imipenem - therapeutic use Mass Spectrometry Substrate Specificity - drug effects Trypsin - chemistry
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