(‐)Epicatechin stimulates ERK‐dependent cyclic AMP response element activity and up‐regulates GluR2 in cortical neurons

Emerging evidence suggests that the cellular actions of flavonoids relate not simply to their antioxidant potential but also to the modulation of protein kinase signalling pathways. We investigated in primary cortical neurons, the ability of the flavan‐3‐ol, (‐)epicatechin, and its human metabolites...

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Veröffentlicht in:	Journal of neurochemistry 2007-06, Vol.101 (6), p.1596-1606
Hauptverfasser:	Schroeter, Hagen, Bahia, Parmvir, Spencer, Jeremy P. E., Sheppard, Olivia, Rattray, Marcus, Cadenas, Enrique, Rice‐Evans, Catherine, Williams, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Akt Animals antioxidants Biochemistry Biological and medical sciences Bipolar disorders Catechin - metabolism Catechin - pharmacology Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cyclic AMP Response Element-Binding Protein - metabolism cyclic AMP‐response element binding protein Extracellular Signal-Regulated MAP Kinases - physiology flavonoids Fundamental and applied biological sciences. Psychology Gene expression Kinases Medical sciences Mice mitogen‐activated protein kinase Molecular and cellular biology Molecular genetics Mood disorders neurodegeneration Neurology Neurons - drug effects Neurons - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, AMPA - biosynthesis Ribonucleic acid RNA RNA, Messenger - metabolism Signal transduction Transcription. Transcription factor. Splicing. Rna processing Up-Regulation
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