Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study

Abstract Background Most patients with ulcerative colitis (UC) rely predominantly on medication for disease control. Diet interventions can reduce pharmaceutical expenditures and prolong remission. We designed a prospective study to evaluate whether an immunoglobulin G (IgG)-guided exclusion diet wo...

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Veröffentlicht in:Inflammatory bowel diseases 2018-08, Vol.24 (9), p.1918-1925
Hauptverfasser: Jian, Liu, Anqi, He, Gang, Liu, Litian, Wang, Yanyan, Xu, Mengdi, Wang, Tong, Liu
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container_end_page 1925
container_issue 9
container_start_page 1918
container_title Inflammatory bowel diseases
container_volume 24
creator Jian, Liu
Anqi, He
Gang, Liu
Litian, Wang
Yanyan, Xu
Mengdi, Wang
Tong, Liu
description Abstract Background Most patients with ulcerative colitis (UC) rely predominantly on medication for disease control. Diet interventions can reduce pharmaceutical expenditures and prolong remission. We designed a prospective study to evaluate whether an immunoglobulin G (IgG)-guided exclusion diet would improve symptoms and quality of life (QoL) in patients with UC. Methods The 6-month diet intervention included 97 patients with UC, who were randomly divided into an intervention group (n = 49) and a control (n = 48) group. Individual diet plans were created for the intervention group according to IgG titers; the control group ate a healthy diet as normal. Observational indices included disease activity, extraintestinal manifestations, nutritional status, and QoL. Relationships between food-specific IgG antibodies and these indices were also analyzed. Results At baseline, there were no significant differences between the groups. Food-specific IgG antibodies were detected in 70.10% of participants. After intervention, the Mayo score was significantly lower in the intervention group than in the control group (2.41 ± 0.89 vs 3.52 ± 1.15, P < 0.05). The number of patients with extraintestinal manifestations decreased from 7 to 2 in the intervention group and from 6 to 5 in the control group. As for nutritive indices, the intervention group had higher mean body mass index and albumin than the control group (23.88 ± 3.31 vs 21.50 ± 6.24 kg/m2, respectively, P < 0.05; 48.05 ± 6.39 vs 45.72 ± 5.48 g/L, respectively, P < 0.05), whereas prealbumin and transferrin were not significantly different between the groups. QoL improved after food exclusion (P < 0.05). Conclusions An IgG-guided exclusion diet ameliorated UC symptoms and improved QoL. Interactions between IgG-based food intolerance and UC warrant further study.
doi_str_mv 10.1093/ibd/izy110
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Diet interventions can reduce pharmaceutical expenditures and prolong remission. We designed a prospective study to evaluate whether an immunoglobulin G (IgG)-guided exclusion diet would improve symptoms and quality of life (QoL) in patients with UC. Methods The 6-month diet intervention included 97 patients with UC, who were randomly divided into an intervention group (n = 49) and a control (n = 48) group. Individual diet plans were created for the intervention group according to IgG titers; the control group ate a healthy diet as normal. Observational indices included disease activity, extraintestinal manifestations, nutritional status, and QoL. Relationships between food-specific IgG antibodies and these indices were also analyzed. Results At baseline, there were no significant differences between the groups. Food-specific IgG antibodies were detected in 70.10% of participants. After intervention, the Mayo score was significantly lower in the intervention group than in the control group (2.41 ± 0.89 vs 3.52 ± 1.15, P &lt; 0.05). The number of patients with extraintestinal manifestations decreased from 7 to 2 in the intervention group and from 6 to 5 in the control group. As for nutritive indices, the intervention group had higher mean body mass index and albumin than the control group (23.88 ± 3.31 vs 21.50 ± 6.24 kg/m2, respectively, P &lt; 0.05; 48.05 ± 6.39 vs 45.72 ± 5.48 g/L, respectively, P &lt; 0.05), whereas prealbumin and transferrin were not significantly different between the groups. QoL improved after food exclusion (P &lt; 0.05). Conclusions An IgG-guided exclusion diet ameliorated UC symptoms and improved QoL. Interactions between IgG-based food intolerance and UC warrant further study.</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1093/ibd/izy110</identifier><identifier>PMID: 29788288</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Aged ; Autoantibodies - blood ; Autoantibodies - immunology ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - diet therapy ; Colitis, Ulcerative - immunology ; Diet - methods ; Female ; Food Analysis ; Food Intolerance - diet therapy ; Food Intolerance - immunology ; Humans ; Immunoglobulin G - immunology ; Male ; Middle Aged ; Prospective Studies ; Quality of Life ; Treatment Outcome ; Young Adult</subject><ispartof>Inflammatory bowel diseases, 2018-08, Vol.24 (9), p.1918-1925</ispartof><rights>2018 Crohn's &amp; Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2018</rights><rights>2018 Crohn’s &amp; Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-b702863d4af822e7e3dabbee5a9d4cc4c418ef8d0bc2cbc54ea74c37eabc4f0f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29788288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jian, Liu</creatorcontrib><creatorcontrib>Anqi, He</creatorcontrib><creatorcontrib>Gang, Liu</creatorcontrib><creatorcontrib>Litian, Wang</creatorcontrib><creatorcontrib>Yanyan, Xu</creatorcontrib><creatorcontrib>Mengdi, Wang</creatorcontrib><creatorcontrib>Tong, Liu</creatorcontrib><title>Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Abstract Background Most patients with ulcerative colitis (UC) rely predominantly on medication for disease control. Diet interventions can reduce pharmaceutical expenditures and prolong remission. We designed a prospective study to evaluate whether an immunoglobulin G (IgG)-guided exclusion diet would improve symptoms and quality of life (QoL) in patients with UC. Methods The 6-month diet intervention included 97 patients with UC, who were randomly divided into an intervention group (n = 49) and a control (n = 48) group. Individual diet plans were created for the intervention group according to IgG titers; the control group ate a healthy diet as normal. Observational indices included disease activity, extraintestinal manifestations, nutritional status, and QoL. Relationships between food-specific IgG antibodies and these indices were also analyzed. Results At baseline, there were no significant differences between the groups. Food-specific IgG antibodies were detected in 70.10% of participants. After intervention, the Mayo score was significantly lower in the intervention group than in the control group (2.41 ± 0.89 vs 3.52 ± 1.15, P &lt; 0.05). The number of patients with extraintestinal manifestations decreased from 7 to 2 in the intervention group and from 6 to 5 in the control group. As for nutritive indices, the intervention group had higher mean body mass index and albumin than the control group (23.88 ± 3.31 vs 21.50 ± 6.24 kg/m2, respectively, P &lt; 0.05; 48.05 ± 6.39 vs 45.72 ± 5.48 g/L, respectively, P &lt; 0.05), whereas prealbumin and transferrin were not significantly different between the groups. QoL improved after food exclusion (P &lt; 0.05). Conclusions An IgG-guided exclusion diet ameliorated UC symptoms and improved QoL. Interactions between IgG-based food intolerance and UC warrant further study.</description><subject>Adult</subject><subject>Aged</subject><subject>Autoantibodies - blood</subject><subject>Autoantibodies - immunology</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colitis, Ulcerative - diet therapy</subject><subject>Colitis, Ulcerative - immunology</subject><subject>Diet - methods</subject><subject>Female</subject><subject>Food Analysis</subject><subject>Food Intolerance - diet therapy</subject><subject>Food Intolerance - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk5v_AGSG0GEuqTN1tS7OrY5GCjMXZd8nEqkbWrTDuuvN7rppZyLvISHl3MehC4puaMkicZG6rH57CklR2hIJ9E0YJyxY59JzAOSJHyAzpx7IyT0k5yiQZjEnIecDxEsrNV4_qGKzhlb4QfhQGMfVq9LnFatkVYbcDgtCtgZ0fq46cu6taXDpsLbQkEjWrMDPLOFaY27xyl-bqyrQf18b9pO9-foJBeFg4vDO0Lbxfxl9hisn5arWboOVETjNpAxCfk00kzkPAwhhkgLKQEmItFMKaYY5ZBzTaQKlVQTBiJmKopBSMVykkcjdLPvrRv73oFrs9I4BUUhKrCdy0LCIuov99ZG6HaPKr-sayDP6saUoukzSrJvrZnXmu21evjq0NvJEvQf-uvRA9d7wHb1f0VfY-OCtg</recordid><startdate>20180816</startdate><enddate>20180816</enddate><creator>Jian, Liu</creator><creator>Anqi, He</creator><creator>Gang, Liu</creator><creator>Litian, Wang</creator><creator>Yanyan, Xu</creator><creator>Mengdi, Wang</creator><creator>Tong, Liu</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180816</creationdate><title>Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study</title><author>Jian, Liu ; Anqi, He ; Gang, Liu ; Litian, Wang ; Yanyan, Xu ; Mengdi, Wang ; Tong, Liu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-b702863d4af822e7e3dabbee5a9d4cc4c418ef8d0bc2cbc54ea74c37eabc4f0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Autoantibodies - blood</topic><topic>Autoantibodies - immunology</topic><topic>Colitis, Ulcerative - blood</topic><topic>Colitis, Ulcerative - diet therapy</topic><topic>Colitis, Ulcerative - immunology</topic><topic>Diet - methods</topic><topic>Female</topic><topic>Food Analysis</topic><topic>Food Intolerance - diet therapy</topic><topic>Food Intolerance - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jian, Liu</creatorcontrib><creatorcontrib>Anqi, He</creatorcontrib><creatorcontrib>Gang, Liu</creatorcontrib><creatorcontrib>Litian, Wang</creatorcontrib><creatorcontrib>Yanyan, Xu</creatorcontrib><creatorcontrib>Mengdi, Wang</creatorcontrib><creatorcontrib>Tong, Liu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jian, Liu</au><au>Anqi, He</au><au>Gang, Liu</au><au>Litian, Wang</au><au>Yanyan, Xu</au><au>Mengdi, Wang</au><au>Tong, Liu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2018-08-16</date><risdate>2018</risdate><volume>24</volume><issue>9</issue><spage>1918</spage><epage>1925</epage><pages>1918-1925</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Abstract Background Most patients with ulcerative colitis (UC) rely predominantly on medication for disease control. Diet interventions can reduce pharmaceutical expenditures and prolong remission. We designed a prospective study to evaluate whether an immunoglobulin G (IgG)-guided exclusion diet would improve symptoms and quality of life (QoL) in patients with UC. Methods The 6-month diet intervention included 97 patients with UC, who were randomly divided into an intervention group (n = 49) and a control (n = 48) group. Individual diet plans were created for the intervention group according to IgG titers; the control group ate a healthy diet as normal. Observational indices included disease activity, extraintestinal manifestations, nutritional status, and QoL. Relationships between food-specific IgG antibodies and these indices were also analyzed. Results At baseline, there were no significant differences between the groups. Food-specific IgG antibodies were detected in 70.10% of participants. After intervention, the Mayo score was significantly lower in the intervention group than in the control group (2.41 ± 0.89 vs 3.52 ± 1.15, P &lt; 0.05). The number of patients with extraintestinal manifestations decreased from 7 to 2 in the intervention group and from 6 to 5 in the control group. As for nutritive indices, the intervention group had higher mean body mass index and albumin than the control group (23.88 ± 3.31 vs 21.50 ± 6.24 kg/m2, respectively, P &lt; 0.05; 48.05 ± 6.39 vs 45.72 ± 5.48 g/L, respectively, P &lt; 0.05), whereas prealbumin and transferrin were not significantly different between the groups. QoL improved after food exclusion (P &lt; 0.05). Conclusions An IgG-guided exclusion diet ameliorated UC symptoms and improved QoL. Interactions between IgG-based food intolerance and UC warrant further study.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>29788288</pmid><doi>10.1093/ibd/izy110</doi><tpages>8</tpages></addata></record>
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source MEDLINE; Oxford University Press Journals All Titles (1996-Current)
subjects Adult
Aged
Autoantibodies - blood
Autoantibodies - immunology
Colitis, Ulcerative - blood
Colitis, Ulcerative - diet therapy
Colitis, Ulcerative - immunology
Diet - methods
Female
Food Analysis
Food Intolerance - diet therapy
Food Intolerance - immunology
Humans
Immunoglobulin G - immunology
Male
Middle Aged
Prospective Studies
Quality of Life
Treatment Outcome
Young Adult
title Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study
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