Pericytes in the Premetastatic Niche
The premetastatic niche formed by primary tumor-derived molecules contributes to fixation of cancer metastasis. The design of efficient therapies is limited by the current lack of knowledge about the details of cellular and molecular mechanisms involved in the premetastatic niche formation. Recently...
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Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2018-06, Vol.78 (11), p.2779-2786 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The premetastatic niche formed by primary tumor-derived molecules contributes to fixation of cancer metastasis. The design of efficient therapies is limited by the current lack of knowledge about the details of cellular and molecular mechanisms involved in the premetastatic niche formation. Recently, the role of pericytes in the premetastatic niche formation and lung metastatic tropism was explored by using state-of-the-art techniques, including
lineage-tracing and mice with pericyte-specific KLF4 deletion. Strikingly, genetic inactivation of KLF4 in pericytes inhibits pulmonary pericyte expansion and decreases metastasis in the lung. Here, we summarize and evaluate recent advances in the understanding of pericyte contribution to premetastatic niche formation.
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ISSN: | 0008-5472 1538-7445 1538-7445 |
DOI: | 10.1158/0008-5472.can-17-3883 |