Oleoylethanolamide increases the expression of PPAR-Α and reduces appetite and body weight in obese people: A clinical trial
Obesity is a crucial public health problem worldwide and is considered as the main cause of many chronic diseases. The present study evaluated the effects of Oleoylethanolamide (OEA) supplementation on proximal proliferator-activated receptor-α (PPAR-α) gene expression, appetite sensations, and anth...
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| Veröffentlicht in: | Appetite 2018-09, Vol.128, p.44-49 |
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| creator | Laleh, Payahoo Yaser, Khajebishak Abolfazl, Barzegari Shahriar, Alipour Mohammad, Asghari Jafarabadi Nazila, Farrin Alireza, Ostadrahimi |
| description | Obesity is a crucial public health problem worldwide and is considered as the main cause of many chronic diseases. The present study evaluated the effects of Oleoylethanolamide (OEA) supplementation on proximal proliferator-activated receptor-α (PPAR-α) gene expression, appetite sensations, and anthropometric measurements in obese people. This randomized, double-blind, placebo-controlled clinical trial was carried out on 60 healthy obese people in Tabriz, Iran, in 2016. The eligible subjects were divided into an intervention group (who received two 125 mg OEA capsules daily) and a placebo group (who received the same amount of starches) and treated for 60 days. Anthropometric measurements and body composition were assessed in a fasting state at baseline and at the end of the study. The visual analogue scales (VAS) were used to assess appetite sensations. Quantitative real-time PCR analysis targeting the 16S rRNA gene of PPAR-α was done. Analysis was done on 56 participants who continued intervention until the end of the study. A significant increase in PPAR-α gene expression was observed in the intervention group (p |
| doi_str_mv | 10.1016/j.appet.2018.05.129 |
| format | Article |
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The present study evaluated the effects of Oleoylethanolamide (OEA) supplementation on proximal proliferator-activated receptor-α (PPAR-α) gene expression, appetite sensations, and anthropometric measurements in obese people. This randomized, double-blind, placebo-controlled clinical trial was carried out on 60 healthy obese people in Tabriz, Iran, in 2016. The eligible subjects were divided into an intervention group (who received two 125 mg OEA capsules daily) and a placebo group (who received the same amount of starches) and treated for 60 days. Anthropometric measurements and body composition were assessed in a fasting state at baseline and at the end of the study. The visual analogue scales (VAS) were used to assess appetite sensations. Quantitative real-time PCR analysis targeting the 16S rRNA gene of PPAR-α was done. Analysis was done on 56 participants who continued intervention until the end of the study. A significant increase in PPAR-α gene expression was observed in the intervention group (p < 0.001). Weight, body mass index, waist circumference, and fat percent decreased significantly at the end of the study in the intervention group (all p < 0.01). Hunger, the desire to eat, and cravings for sweet foods decreased significantly and fullness increased significantly by the end of study in the intervention group at the end of study (all p < 0.01). The fullness item increased significantly by the end of study in the intervention group (p < 0.001). Use of OEA as a complementary approach could be effective in suppressing appetite and modulating energy balance in obese people.</description><identifier>ISSN: 0195-6663</identifier><identifier>EISSN: 1095-8304</identifier><identifier>DOI: 10.1016/j.appet.2018.05.129</identifier><identifier>PMID: 29787831</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Anthropometric measurements ; Appetite ; Appetite - drug effects ; Body Weight - drug effects ; Diet, Reducing - methods ; Dietary Supplements ; Double-Blind Method ; Endocannabinoids - administration & dosage ; Energy homeostasis ; Female ; Humans ; Iran ; Male ; Middle Aged ; Obesity ; Obesity - metabolism ; Obesity - therapy ; Oleic Acids - administration & dosage ; Oleoylethanolamide ; PPAR alpha - drug effects ; PPAR-α ; Satiation - drug effects ; Treatment Outcome ; Weight Loss ; Young Adult</subject><ispartof>Appetite, 2018-09, Vol.128, p.44-49</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c274t-b65454fc3ae8fb11e2d03885a08b3bcafb90815da11f0da9f91aae8737d53a773</citedby><cites>FETCH-LOGICAL-c274t-b65454fc3ae8fb11e2d03885a08b3bcafb90815da11f0da9f91aae8737d53a773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0195666318301557$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29787831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laleh, Payahoo</creatorcontrib><creatorcontrib>Yaser, Khajebishak</creatorcontrib><creatorcontrib>Abolfazl, Barzegari</creatorcontrib><creatorcontrib>Shahriar, Alipour</creatorcontrib><creatorcontrib>Mohammad, Asghari Jafarabadi</creatorcontrib><creatorcontrib>Nazila, Farrin</creatorcontrib><creatorcontrib>Alireza, Ostadrahimi</creatorcontrib><title>Oleoylethanolamide increases the expression of PPAR-Α and reduces appetite and body weight in obese people: A clinical trial</title><title>Appetite</title><addtitle>Appetite</addtitle><description>Obesity is a crucial public health problem worldwide and is considered as the main cause of many chronic diseases. The present study evaluated the effects of Oleoylethanolamide (OEA) supplementation on proximal proliferator-activated receptor-α (PPAR-α) gene expression, appetite sensations, and anthropometric measurements in obese people. This randomized, double-blind, placebo-controlled clinical trial was carried out on 60 healthy obese people in Tabriz, Iran, in 2016. The eligible subjects were divided into an intervention group (who received two 125 mg OEA capsules daily) and a placebo group (who received the same amount of starches) and treated for 60 days. Anthropometric measurements and body composition were assessed in a fasting state at baseline and at the end of the study. The visual analogue scales (VAS) were used to assess appetite sensations. Quantitative real-time PCR analysis targeting the 16S rRNA gene of PPAR-α was done. Analysis was done on 56 participants who continued intervention until the end of the study. A significant increase in PPAR-α gene expression was observed in the intervention group (p < 0.001). Weight, body mass index, waist circumference, and fat percent decreased significantly at the end of the study in the intervention group (all p < 0.01). Hunger, the desire to eat, and cravings for sweet foods decreased significantly and fullness increased significantly by the end of study in the intervention group at the end of study (all p < 0.01). The fullness item increased significantly by the end of study in the intervention group (p < 0.001). Use of OEA as a complementary approach could be effective in suppressing appetite and modulating energy balance in obese people.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anthropometric measurements</subject><subject>Appetite</subject><subject>Appetite - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Diet, Reducing - methods</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Endocannabinoids - administration & dosage</subject><subject>Energy homeostasis</subject><subject>Female</subject><subject>Humans</subject><subject>Iran</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Obesity - therapy</subject><subject>Oleic Acids - administration & dosage</subject><subject>Oleoylethanolamide</subject><subject>PPAR alpha - drug effects</subject><subject>PPAR-α</subject><subject>Satiation - drug effects</subject><subject>Treatment Outcome</subject><subject>Weight Loss</subject><subject>Young Adult</subject><issn>0195-6663</issn><issn>1095-8304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAQgEVpabbbPkGg6NiLXcmyLLmQwxL6B4GEkpyFLI2zWrSWI2mT7KEP0RfrM1XZTXvsaYbhm78PoVNKakpo93FT63mGXDeEyprwmjb9C7SgpOeVZKR9iRaElrzrOnaC3qS0IYQwLsRrdNL0QgrJ6AL9vPQQ9h7yWk_B662zgN1kIugECec1YHicI6TkwoTDiK-uVj-q37-wniyOYHemUIczXIZDcQh2jx_A3a5zGYTDAAnwDGH28AmvsPFuckZ7nKPT_i16NWqf4N1zXKKbL5-vz79VF5dfv5-vLirTiDZXQ8db3o6GaZDjQCk0ljApuSZyYIPR49ATSbnVlI7E6n7sqS6oYMJypoVgS_ThOHeO4W4HKautSwa81xOEXVINaRmVTBRVS8SOqIkhpQijmqPb6rhXlKgn72qjDg-rJ--KcFW8l673zwt2wxbsv56_ogtwdgSgvHnvIKpkHEwGrItgsrLB_XfBHziEl3E</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Laleh, Payahoo</creator><creator>Yaser, Khajebishak</creator><creator>Abolfazl, Barzegari</creator><creator>Shahriar, Alipour</creator><creator>Mohammad, Asghari Jafarabadi</creator><creator>Nazila, Farrin</creator><creator>Alireza, Ostadrahimi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>Oleoylethanolamide increases the expression of PPAR-Α and reduces appetite and body weight in obese people: A clinical trial</title><author>Laleh, Payahoo ; Yaser, Khajebishak ; Abolfazl, Barzegari ; Shahriar, Alipour ; Mohammad, Asghari Jafarabadi ; Nazila, Farrin ; Alireza, Ostadrahimi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-b65454fc3ae8fb11e2d03885a08b3bcafb90815da11f0da9f91aae8737d53a773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anthropometric measurements</topic><topic>Appetite</topic><topic>Appetite - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Diet, Reducing - methods</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Endocannabinoids - administration & dosage</topic><topic>Energy homeostasis</topic><topic>Female</topic><topic>Humans</topic><topic>Iran</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Obesity - therapy</topic><topic>Oleic Acids - administration & dosage</topic><topic>Oleoylethanolamide</topic><topic>PPAR alpha - drug effects</topic><topic>PPAR-α</topic><topic>Satiation - drug effects</topic><topic>Treatment Outcome</topic><topic>Weight Loss</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laleh, Payahoo</creatorcontrib><creatorcontrib>Yaser, Khajebishak</creatorcontrib><creatorcontrib>Abolfazl, Barzegari</creatorcontrib><creatorcontrib>Shahriar, Alipour</creatorcontrib><creatorcontrib>Mohammad, Asghari Jafarabadi</creatorcontrib><creatorcontrib>Nazila, Farrin</creatorcontrib><creatorcontrib>Alireza, Ostadrahimi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Appetite</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laleh, Payahoo</au><au>Yaser, Khajebishak</au><au>Abolfazl, Barzegari</au><au>Shahriar, Alipour</au><au>Mohammad, Asghari Jafarabadi</au><au>Nazila, Farrin</au><au>Alireza, Ostadrahimi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oleoylethanolamide increases the expression of PPAR-Α and reduces appetite and body weight in obese people: A clinical trial</atitle><jtitle>Appetite</jtitle><addtitle>Appetite</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>128</volume><spage>44</spage><epage>49</epage><pages>44-49</pages><issn>0195-6663</issn><eissn>1095-8304</eissn><abstract>Obesity is a crucial public health problem worldwide and is considered as the main cause of many chronic diseases. The present study evaluated the effects of Oleoylethanolamide (OEA) supplementation on proximal proliferator-activated receptor-α (PPAR-α) gene expression, appetite sensations, and anthropometric measurements in obese people. This randomized, double-blind, placebo-controlled clinical trial was carried out on 60 healthy obese people in Tabriz, Iran, in 2016. The eligible subjects were divided into an intervention group (who received two 125 mg OEA capsules daily) and a placebo group (who received the same amount of starches) and treated for 60 days. Anthropometric measurements and body composition were assessed in a fasting state at baseline and at the end of the study. The visual analogue scales (VAS) were used to assess appetite sensations. Quantitative real-time PCR analysis targeting the 16S rRNA gene of PPAR-α was done. Analysis was done on 56 participants who continued intervention until the end of the study. A significant increase in PPAR-α gene expression was observed in the intervention group (p < 0.001). Weight, body mass index, waist circumference, and fat percent decreased significantly at the end of the study in the intervention group (all p < 0.01). Hunger, the desire to eat, and cravings for sweet foods decreased significantly and fullness increased significantly by the end of study in the intervention group at the end of study (all p < 0.01). The fullness item increased significantly by the end of study in the intervention group (p < 0.001). Use of OEA as a complementary approach could be effective in suppressing appetite and modulating energy balance in obese people.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29787831</pmid><doi>10.1016/j.appet.2018.05.129</doi><tpages>6</tpages></addata></record> |
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| ispartof | Appetite, 2018-09, Vol.128, p.44-49 |
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| subjects | Adolescent Adult Anthropometric measurements Appetite Appetite - drug effects Body Weight - drug effects Diet, Reducing - methods Dietary Supplements Double-Blind Method Endocannabinoids - administration & dosage Energy homeostasis Female Humans Iran Male Middle Aged Obesity Obesity - metabolism Obesity - therapy Oleic Acids - administration & dosage Oleoylethanolamide PPAR alpha - drug effects PPAR-α Satiation - drug effects Treatment Outcome Weight Loss Young Adult |
| title | Oleoylethanolamide increases the expression of PPAR-Α and reduces appetite and body weight in obese people: A clinical trial |
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