Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines

A facile, general, and economical synthesis of diversely functionalized pyrimidines has been realized under basic conditions via the copper-catalyzed cyclization of ketones with nitriles. The reaction proceeds via a novel pathway involving the nitriles acting as electrophiles and consecutive C–C bon...

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Veröffentlicht in:	Organic letters 2018-06, Vol.20 (11), p.3399-3402
Hauptverfasser:	Su, Lebin, Sun, Kang, Pan, Neng, Liu, Long, Sun, Mengli, Dong, Jianyu, Zhou, Yongbo, Yin, Shuang-Feng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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