Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines

Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines

A facile, general, and economical synthesis of diversely functionalized pyrimidines has been realized under basic conditions via the copper-catalyzed cyclization of ketones with nitriles. The reaction proceeds via a novel pathway involving the nitriles acting as electrophiles and consecutive C–C bon...

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Veröffentlicht in:Organic letters 2018-06, Vol.20 (11), p.3399-3402
Hauptverfasser: Su, Lebin, Sun, Kang, Pan, Neng, Liu, Long, Sun, Mengli, Dong, Jianyu, Zhou, Yongbo, Yin, Shuang-Feng
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container_end_page 3402
container_issue 11
container_start_page 3399
container_title Organic letters
container_volume 20
creator Su, Lebin
Sun, Kang
Pan, Neng
Liu, Long
Sun, Mengli
Dong, Jianyu
Zhou, Yongbo
Yin, Shuang-Feng
description A facile, general, and economical synthesis of diversely functionalized pyrimidines has been realized under basic conditions via the copper-catalyzed cyclization of ketones with nitriles. The reaction proceeds via a novel pathway involving the nitriles acting as electrophiles and consecutive C–C bond and two C–N bond formations and shows broad substrate scope and good tolerance of many important functional groups. This strategy represents a new platform for constructing pyrimidine structures.
doi_str_mv 10.1021/acs.orglett.8b01324
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title Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines
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