Overexpression of Tet3 in donor cells enhances goat somatic cell nuclear transfer efficiency

Ten–eleven translocation 3 (TET3) mediates active DNA demethylation of paternal genomes during mouse embryonic development. However, the mechanism of DNA demethylation in goat embryos remains unknown. In addition, aberrant DNA methylation reprogramming prevalently occurs in embryos cloned by somatic...

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Veröffentlicht in:	The FEBS journal 2018-07, Vol.285 (14), p.2708-2723
Hauptverfasser:	Han, Chengquan, Deng, Ruizhi, Mao, Tingchao, Luo, Yan, Wei, Biao, Meng, Peng, Zhao, Lu, Zhang, Qing, Quan, Fusheng, Liu, Jun, Zhang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives 5-Methylcytosine - metabolism Animals Blastocyst - metabolism Blastocysts Cellular Reprogramming Cloning, Organism - methods Demethylation Deoxyribonucleic acid Dioxygenases - genetics Dioxygenases - metabolism DNA DNA Demethylation DNA methylation Embryogenesis Embryonic Development Embryonic growth stage Embryos Female Gene expression Gene Expression Regulation, Developmental Genomes goat Goats Goats - embryology Goats - genetics Implantation Male Nanog Homeobox Protein - genetics Nanog Homeobox Protein - metabolism Nuclear transfer Nuclear Transfer Techniques Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Pluripotency Pregnancy Somatic cell nuclear transfer somatic cell nuclear transfer efficiency Somatic cells Surgical implants Tet3 Translocation
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