Development of a Topical 48-H Release Formulation as an Anti-scarring Treatment for Deep Partial-Thickness Burns

The purpose of this study was to develop pirfenidone (PF) ointment formulations for a dose finding study in the prophylactic treatment of deep partial-thickness burns in a mouse model. A preformulation study was performed to evaluate the solubility of PF in buffers and different solvents and its sta...

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Veröffentlicht in:	AAPS PharmSciTech 2018-07, Vol.19 (5), p.2264-2275
Hauptverfasser:	Dorati, Rossella, Medina, Jorge L., DeLuca, Patrick P., Leung, Kai P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Burns - drug therapy Burns - metabolism Burns - pathology Cicatrix - drug therapy Cicatrix - metabolism Cicatrix - pathology Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - metabolism Drug Liberation Male Mice Mice, Inbred C57BL Ointments - administration & dosage Ointments - metabolism Pharmacology/Toxicology Pharmacy Pyridones - administration & dosage Pyridones - metabolism Research Article Treatment Outcome Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Wound Healing - drug effects Wound Healing - physiology
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