5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus

The Streptomyces clavuligerus clavam gene cluster was examined to identify genes specifically involved in 5S clavam biosynthesis. A reduction/loss of 5S clavam production was seen in cvm2 and cvm5 gene mutants, and a clavam metabolite not previously observed, 2-carboxymethylideneclavam, accumulated...

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Veröffentlicht in:	Chemistry & biology 2007-02, Vol.14 (2), p.131-142
Hauptverfasser:	Tahlan, Kapil, Anders, Cecilia, Wong, Annie, Mosher, Roy H, Beatty, Perrin H, Brumlik, Michael J, Griffin, Allison, Hughes, Claire, Griffin, John, Barton, Barry, Jensen, Susan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Southern Chromatography, Liquid Clavulanic Acid - biosynthesis Clavulanic Acids - biosynthesis DNA, Bacterial - genetics Genes, Bacterial Mass Spectrometry Multigene Family Mutagenesis, Insertional Sequence Analysis, DNA Streptomyces - genetics Streptomyces - metabolism Streptomyces clavuligerus
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