Total flavonoid extract of Epimedium herb increases the peak bone mass of young rats involving enhanced activation of the AC10/cAMP/PKA/CREB pathway

Epimedium sagittatum brevicornum Maxim. is an important traditional Chinese herb that has long been used to promote bone fracture healing and treat osteoporosis. Achieving peak bone mass by adolescence has now been accepted to be fundamental for preventing osteoporosis in adulthood life. This study...

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Veröffentlicht in:	Journal of ethnopharmacology 2018-09, Vol.223 (NA), p.76-87
Hauptverfasser:	Xi, Hui-Rong, Ma, Hui-Ping, Yang, Fang-Fang, Gao, Yu-Hai, Zhou, Jian, Wang, Yuan-Yuan, Li, Wen-Yuan, Xian, Cory J., Chen, Ke-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Bone and Bones - diagnostic imaging Bone and Bones - drug effects Bone and Bones - metabolism Bone Density - drug effects Bone mineral density Bone Morphogenetic Protein 2 - genetics Collagen Type I - genetics Core Binding Factor Alpha 1 Subunit - genetics Cyclic AMP - blood Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Dual-energy X-ray absorptiometry Epimedium Epimedium herb Female Flavonoids - pharmacology Micro-CT Osteoporosis Peak bone mass Rats, Wistar Signal Transduction - drug effects Transcription Factors - genetics X-Ray Microtomography
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