Design and synthesis of aminocoumarin derivatives as DPP-IV inhibitors and anticancer agents

We have designed 3-aminocoumarin derivatives 11a–f and 7-amino-4-methylcoumarin derivatives 17a–l for DPP-IV inhibition. Compounds 17h, 17i and 17k showed moderate activity as compared to standard drug Vildagliptin. Interestingly, compound 17l showed very good anticancer activity against A549 cell l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic chemistry 2018-09, Vol.79, p.277-284
Hauptverfasser:	Soni, Rina, Soman, Shubhangi S.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Aminocoumarin derivatives 7-Amino-4-methylcoumarin derivatives Aminocoumarins - chemical synthesis Aminocoumarins - chemistry Aminocoumarins - pharmacology Anticancer activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Dipeptidyl Peptidase 4 - metabolism Dipeptidyl-Peptidase IV Inhibitors - chemical synthesis Dipeptidyl-Peptidase IV Inhibitors - chemistry Dipeptidyl-Peptidase IV Inhibitors - pharmacology Dose-Response Relationship, Drug DPP-IV inhibition Drug Design Drug Screening Assays, Antitumor Humans MCF-7 Cells Molecular Structure Recombinant Proteins - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!