Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder
ABSTRACT Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence an...
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| Veröffentlicht in: | Microbiology and immunology 2018-07, Vol.62 (7), p.473-476 |
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| container_title | Microbiology and immunology |
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| creator | Honda, Tomoyuki Sofuku, Kozue Matsunaga, Hidenori Tachibana, Masaya Mohri, Ikuko Taniike, Masako Tomonaga, Keizo |
| description | ABSTRACT
Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence analysis, western blotting and radio ligand assay. The prevalence of antibodies against bornavirus‐specific speckles, nucleoprotein and phosphoprotein were 22%, 48%, and 33%, respectively, in children with ASD. According to our criteria, the prevalence of antibodies against bornaviruses was 7.4% in children with ASD. This is the first report of the serological prevalence of bornavirus in Japanese children. Our results provide valuable baseline‐data for future studies regarding bornavirus epidemiology in children. |
| doi_str_mv | 10.1111/1348-0421.12603 |
| format | Article |
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Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence analysis, western blotting and radio ligand assay. The prevalence of antibodies against bornavirus‐specific speckles, nucleoprotein and phosphoprotein were 22%, 48%, and 33%, respectively, in children with ASD. According to our criteria, the prevalence of antibodies against bornaviruses was 7.4% in children with ASD. This is the first report of the serological prevalence of bornavirus in Japanese children. Our results provide valuable baseline‐data for future studies regarding bornavirus epidemiology in children.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/1348-0421.12603</identifier><identifier>PMID: 29786872</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Antibodies ; antibody ; Autism ; Autistic children ; Borna disease ; bornavirus ; Children ; Epidemiology ; Immunofluorescence ; Immunoglobulins ; Proteins ; Viruses ; Western blotting</subject><ispartof>Microbiology and immunology, 2018-07, Vol.62 (7), p.473-476</ispartof><rights>2018 The Societies and John Wiley & Sons Australia, Ltd</rights><rights>2018 The Societies and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5023-57de0f7f32cd1363413b36550202462c2908bdf1c2aad696779bfd73e0e8dc723</citedby><cites>FETCH-LOGICAL-c5023-57de0f7f32cd1363413b36550202462c2908bdf1c2aad696779bfd73e0e8dc723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1348-0421.12603$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1348-0421.12603$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29786872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Honda, Tomoyuki</creatorcontrib><creatorcontrib>Sofuku, Kozue</creatorcontrib><creatorcontrib>Matsunaga, Hidenori</creatorcontrib><creatorcontrib>Tachibana, Masaya</creatorcontrib><creatorcontrib>Mohri, Ikuko</creatorcontrib><creatorcontrib>Taniike, Masako</creatorcontrib><creatorcontrib>Tomonaga, Keizo</creatorcontrib><title>Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>ABSTRACT
Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence analysis, western blotting and radio ligand assay. The prevalence of antibodies against bornavirus‐specific speckles, nucleoprotein and phosphoprotein were 22%, 48%, and 33%, respectively, in children with ASD. According to our criteria, the prevalence of antibodies against bornaviruses was 7.4% in children with ASD. This is the first report of the serological prevalence of bornavirus in Japanese children. Our results provide valuable baseline‐data for future studies regarding bornavirus epidemiology in children.</description><subject>Antibodies</subject><subject>antibody</subject><subject>Autism</subject><subject>Autistic children</subject><subject>Borna disease</subject><subject>bornavirus</subject><subject>Children</subject><subject>Epidemiology</subject><subject>Immunofluorescence</subject><subject>Immunoglobulins</subject><subject>Proteins</subject><subject>Viruses</subject><subject>Western blotting</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkTlPxDAQhS0EYpejpkOWaGjC-khibwmIUyAooLYce8J6lQs7Ae2_x2FhCxrcjOT3zdPMG4SOKDmj8c0oT2VCUkbPKMsJ30LTzc82mhIusyTLCZmgvRCWhDDBZLqLJmwuZC4Fm6Lu2cOHrqAxgNsS66Z3RWsdBKzftGtCjy9a32hsXQAdAH84PwTc-baHqGLX4Hvd6QaiZBaush4a_On6BdZD70KNQwem90M9GrTegj9AO6WuAhz-1H30en31cnmbPDzd3F2ePyQmI4wnmbBASlFyZizlOU8pL3ieRY2wNGeGzYksbEkN09rm81yIeVFawYGAtEYwvo9O175x1vcBQq9qFwxUVRy2HYJiMSORUUFJRE_-oMt2iEtXIyUITSWXaaRma8r4NgQPpeq8q7VfKUrUeAw1Rq_G6NX3MWLH8Y_vUNRgN_xv-hHI1sCnq2D1n596vHtcG38BLSuTvw</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Honda, Tomoyuki</creator><creator>Sofuku, Kozue</creator><creator>Matsunaga, Hidenori</creator><creator>Tachibana, Masaya</creator><creator>Mohri, Ikuko</creator><creator>Taniike, Masako</creator><creator>Tomonaga, Keizo</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201807</creationdate><title>Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder</title><author>Honda, Tomoyuki ; Sofuku, Kozue ; Matsunaga, Hidenori ; Tachibana, Masaya ; Mohri, Ikuko ; Taniike, Masako ; Tomonaga, Keizo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5023-57de0f7f32cd1363413b36550202462c2908bdf1c2aad696779bfd73e0e8dc723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antibodies</topic><topic>antibody</topic><topic>Autism</topic><topic>Autistic children</topic><topic>Borna disease</topic><topic>bornavirus</topic><topic>Children</topic><topic>Epidemiology</topic><topic>Immunofluorescence</topic><topic>Immunoglobulins</topic><topic>Proteins</topic><topic>Viruses</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Honda, Tomoyuki</creatorcontrib><creatorcontrib>Sofuku, Kozue</creatorcontrib><creatorcontrib>Matsunaga, Hidenori</creatorcontrib><creatorcontrib>Tachibana, Masaya</creatorcontrib><creatorcontrib>Mohri, Ikuko</creatorcontrib><creatorcontrib>Taniike, Masako</creatorcontrib><creatorcontrib>Tomonaga, Keizo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Honda, Tomoyuki</au><au>Sofuku, Kozue</au><au>Matsunaga, Hidenori</au><au>Tachibana, Masaya</au><au>Mohri, Ikuko</au><au>Taniike, Masako</au><au>Tomonaga, Keizo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiol Immunol</addtitle><date>2018-07</date><risdate>2018</risdate><volume>62</volume><issue>7</issue><spage>473</spage><epage>476</epage><pages>473-476</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><abstract>ABSTRACT
Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence analysis, western blotting and radio ligand assay. The prevalence of antibodies against bornavirus‐specific speckles, nucleoprotein and phosphoprotein were 22%, 48%, and 33%, respectively, in children with ASD. According to our criteria, the prevalence of antibodies against bornaviruses was 7.4% in children with ASD. This is the first report of the serological prevalence of bornavirus in Japanese children. Our results provide valuable baseline‐data for future studies regarding bornavirus epidemiology in children.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29786872</pmid><doi>10.1111/1348-0421.12603</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Freely Accessible Japanese Titles (ERDB Project); Wiley Online Library Journals; Alma/SFX Local Collection |
| subjects | Antibodies antibody Autism Autistic children Borna disease bornavirus Children Epidemiology Immunofluorescence Immunoglobulins Proteins Viruses Western blotting |
| title | Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder |
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