Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis

Interstitial cystitis is a syndrome characterized by detrusor overactivity and chronic inflammation of the bladder. The mechanisms responsible for the altered smooth muscle contractility remain poorly understood. The aim of the study was to investigate the role of intracellular signalling pathways i...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2018-11, Vol.123 (5), p.567-576
Hauptverfasser:	Denizalti, Merve, Durlu‐Kandilci, Nezahat Tugba, Simsek, Gul, Bozkurt, Turgut Emrah, Sahin‐Erdemli, Inci
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Amides - pharmacology Animals Bladder Calcium Carbachol Carbachol - pharmacology Cholinergic Agonists - pharmacology Contraction Cyclophosphamide Cystitis Cystitis, Interstitial - metabolism Cystitis, Interstitial - physiopathology Enzyme inhibitors Enzyme Inhibitors - pharmacology Heparin Heparin - pharmacology Indoles - pharmacology Inhibitors Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors Intracellular signalling Isoforms Kinases Maleimides - pharmacology Muscle contraction Muscle Contraction - drug effects Muscle Relaxants, Central - pharmacology Muscles Protein kinase C Protein Kinase C - metabolism Proteins Pyridines - pharmacology Rats Rho-associated kinase rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - metabolism RhoA protein Rodents Ryanodine Ryanodine - pharmacology Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Signal Transduction Smooth muscle Sodium chloride Urinary Bladder - metabolism Urinary Bladder - physiopathology
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