Identification of a Novel HIV-1 Unique Recombinant Form Comprising CRF01_AE, Subtype B', and CRF65_cpx Among Men Who Have Sex with Men in Jilin, China
The current HIV-1 epidemic in China is featured by diverse subtypes and continual emergence of new recombinant viruses. This study identified a novel unique recombinant form (URF), JL16013, among men who have sex with men (MSM) in Jilin, China. The JL16013 virus was different from all known subtypes...
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| Veröffentlicht in: | AIDS research and human retroviruses 2018-08, Vol.34 (8), p.714-718 |
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| container_title | AIDS research and human retroviruses |
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| creator | Lin, Yuan-Long Song, Bo Shao, Bing Liu, Si-Yu Huo, Qing-Qing Li, Jin Wang, Jia-Ye Wang, Fu-Xiang |
| description | The current HIV-1 epidemic in China is featured by diverse subtypes and continual emergence of new recombinant viruses. This study identified a novel unique recombinant form (URF), JL16013, among men who have sex with men (MSM) in Jilin, China. The JL16013 virus was different from all known subtypes and set up a distinct branch on the phylogenetic tree. This virus had a CRF01_AE backbone with two subtype B' fragments and one CRF65_cpx fragment inserted into gag, pol, env, and nef regions, suggesting that this novel URF might have originated from the CRF01_AE, subtype B', and CRF65_cpx viruses that were cocirculating in Jilin province. This was the first report of the CRF01_AE/B'/CRF65_cpx recombinant in China. Identification of this URF indicated the severity and complexity of the HIV-1 epidemic among MSM in Jilin province. Timely surveillance of new HIV-1 infections and new recombinants among the MSM population is urgently required. |
| doi_str_mv | 10.1089/AID.2018.0109 |
| format | Article |
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This study identified a novel unique recombinant form (URF), JL16013, among men who have sex with men (MSM) in Jilin, China. The JL16013 virus was different from all known subtypes and set up a distinct branch on the phylogenetic tree. This virus had a CRF01_AE backbone with two subtype B' fragments and one CRF65_cpx fragment inserted into gag, pol, env, and nef regions, suggesting that this novel URF might have originated from the CRF01_AE, subtype B', and CRF65_cpx viruses that were cocirculating in Jilin province. This was the first report of the CRF01_AE/B'/CRF65_cpx recombinant in China. Identification of this URF indicated the severity and complexity of the HIV-1 epidemic among MSM in Jilin province. Timely surveillance of new HIV-1 infections and new recombinants among the MSM population is urgently required.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/AID.2018.0109</identifier><identifier>PMID: 29786452</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adult ; AIDS/HIV ; China ; Epidemics ; Gag protein ; Genotype ; HIV ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; HIV-1 - isolation & purification ; Homosexuality, Male ; Human immunodeficiency virus ; Humans ; Male ; Phylogeny ; Protease inhibitors ; Recombinants ; Recombination, Genetic ; Sequence Analysis, DNA ; Sexually transmitted diseases ; STD ; Viruses</subject><ispartof>AIDS research and human retroviruses, 2018-08, Vol.34 (8), p.714-718</ispartof><rights>(©) Copyright 2018, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-522c8108f9f507dcd3df74c499d5730fa6c66aace9a6f31f568b877d763f21dd3</citedby><cites>FETCH-LOGICAL-c321t-522c8108f9f507dcd3df74c499d5730fa6c66aace9a6f31f568b877d763f21dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29786452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yuan-Long</creatorcontrib><creatorcontrib>Song, Bo</creatorcontrib><creatorcontrib>Shao, Bing</creatorcontrib><creatorcontrib>Liu, Si-Yu</creatorcontrib><creatorcontrib>Huo, Qing-Qing</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><creatorcontrib>Wang, Jia-Ye</creatorcontrib><creatorcontrib>Wang, Fu-Xiang</creatorcontrib><title>Identification of a Novel HIV-1 Unique Recombinant Form Comprising CRF01_AE, Subtype B', and CRF65_cpx Among Men Who Have Sex with Men in Jilin, China</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>The current HIV-1 epidemic in China is featured by diverse subtypes and continual emergence of new recombinant viruses. This study identified a novel unique recombinant form (URF), JL16013, among men who have sex with men (MSM) in Jilin, China. The JL16013 virus was different from all known subtypes and set up a distinct branch on the phylogenetic tree. This virus had a CRF01_AE backbone with two subtype B' fragments and one CRF65_cpx fragment inserted into gag, pol, env, and nef regions, suggesting that this novel URF might have originated from the CRF01_AE, subtype B', and CRF65_cpx viruses that were cocirculating in Jilin province. This was the first report of the CRF01_AE/B'/CRF65_cpx recombinant in China. Identification of this URF indicated the severity and complexity of the HIV-1 epidemic among MSM in Jilin province. Timely surveillance of new HIV-1 infections and new recombinants among the MSM population is urgently required.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>China</subject><subject>Epidemics</subject><subject>Gag protein</subject><subject>Genotype</subject><subject>HIV</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - isolation & purification</subject><subject>Homosexuality, Male</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Male</subject><subject>Phylogeny</subject><subject>Protease inhibitors</subject><subject>Recombinants</subject><subject>Recombination, Genetic</subject><subject>Sequence Analysis, DNA</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Viruses</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9v1DAQxS0EotvCkSsaiQM9bBbbiRP7uIQuu6iA1FI4Wl7_YV0l9hInpf0ifF68tHDgNNLMT29m3kPoBcELgrl4s9y8W1BM-AITLB6hGRElKXiF2WM0w5yLglIqjtBxStcYY0Epe4qOqGh4XTE6Q782xobRO6_V6GOA6EDBp3hjO1hvvhYEroL_MVm4sDr2Wx9UGGEVhx7a2O8Hn3z4Du3FChO5PJvD5bQd7_YW3r6egwrmMKmZ1PtbWPYxkx9tgG-7CGt1Y-HS3sJPP-7-dH2AD77zYQ7tLm95hp441SX7_KGeoKvV2Zd2XZx_fr9pl-eFLikZC0ap5tkGJxzDjdGmNK6pdCWEYU2Jnap1XSulrVC1K4ljNd_ypjFNXTpKjClP0Om97n6I-c00yt4nbbtOBRunJCmuaMNITauMvvoPvY7TEPJ1meJY4IpglqnintJDTGmwTmaXejXcSYLlITCpvJGHwOQhsMy_fFCdtr01_-i_CZW_ARatjUI</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Lin, Yuan-Long</creator><creator>Song, Bo</creator><creator>Shao, Bing</creator><creator>Liu, Si-Yu</creator><creator>Huo, Qing-Qing</creator><creator>Li, Jin</creator><creator>Wang, Jia-Ye</creator><creator>Wang, Fu-Xiang</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201808</creationdate><title>Identification of a Novel HIV-1 Unique Recombinant Form Comprising CRF01_AE, Subtype B', and CRF65_cpx Among Men Who Have Sex with Men in Jilin, China</title><author>Lin, Yuan-Long ; 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This study identified a novel unique recombinant form (URF), JL16013, among men who have sex with men (MSM) in Jilin, China. The JL16013 virus was different from all known subtypes and set up a distinct branch on the phylogenetic tree. This virus had a CRF01_AE backbone with two subtype B' fragments and one CRF65_cpx fragment inserted into gag, pol, env, and nef regions, suggesting that this novel URF might have originated from the CRF01_AE, subtype B', and CRF65_cpx viruses that were cocirculating in Jilin province. This was the first report of the CRF01_AE/B'/CRF65_cpx recombinant in China. Identification of this URF indicated the severity and complexity of the HIV-1 epidemic among MSM in Jilin province. Timely surveillance of new HIV-1 infections and new recombinants among the MSM population is urgently required.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>29786452</pmid><doi>10.1089/AID.2018.0109</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult AIDS/HIV China Epidemics Gag protein Genotype HIV HIV Infections - virology HIV-1 - classification HIV-1 - genetics HIV-1 - isolation & purification Homosexuality, Male Human immunodeficiency virus Humans Male Phylogeny Protease inhibitors Recombinants Recombination, Genetic Sequence Analysis, DNA Sexually transmitted diseases STD Viruses |
| title | Identification of a Novel HIV-1 Unique Recombinant Form Comprising CRF01_AE, Subtype B', and CRF65_cpx Among Men Who Have Sex with Men in Jilin, China |
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