Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor

A catalytic asymmetric [3 + 2] cyclization of novel 4-isothiocyanato pyrazolones and isatin-derived ketimines was developed, delivering a wide range of intriguing dispirotriheterocyclic products in high yield with excellent diastereoselectivity and enantioselectivity. A chiral sulfoxide derivative o...

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Veröffentlicht in:	Organic letters 2018-06, Vol.20 (11), p.3394-3398
Hauptverfasser:	Bao, Xiaoze, Wei, Shiqiang, Qian, Xingkai, Qu, Jingping, Wang, Baomin, Zou, Liwei, Ge, Guangbo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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