An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo

Carbonic anhydrase XII (CAXII) is a membrane‐tethered ectoenzyme involved in intracellular pH regulation and overexpressed across various types of human cancer. Because CAXII inhibition shows antitumor activity in vitro, it is thought that the enzyme is mandatory for maximum tumor growth, above all...

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Veröffentlicht in:	International journal of cancer 2018-10, Vol.143 (8), p.2065-2075
Hauptverfasser:	von Neubeck, Bettina, Gondi, Gabor, Riganti, Chiara, Pan, Chenchen, Parra Damas, Arnaldo, Scherb, Hagen, Ertürk, Ali, Zeidler, Reinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	6A10 antibody Anthracycline Antitumor activity Breast cancer Cancer Carbonic anhydrase Carbonic anhydrases CAXII Cell death Chemoresistance Doxorubicin Hypoxia Inhibition Lung cancer Lungs Medical research Metastases Metastasis Monoclonal antibodies Proteins P‐glycoprotein Tumor cells Xenografts
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