Metalation of the Amyotrophic Lateral Sclerosis Mutant Glycine 37 to Arginine Superoxide Dismutase (SOD1) Apoprotein Restores Its Structural and Dynamical Properties in Solution to Those of Metalated Wild-Type SOD1

The G37R copper−zinc superoxide dismutase (SOD1) is one of the many mutant SOD1 proteins known to cause familial amyotrophic lateral sclerosis by an unknown mechanism. This particular mutation occurs in the β barrel plug, a region proposed to be critical for the structural stability of the protein....

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