What do we (need to) know about the kinetic properties of nanoparticles in the body?
Nowadays the development and applications of nanotechnology are of major importance in both industrial and consumer areas. However, the knowledge on human exposure and possible toxicity of nanotechnology products is limited. To understand the mechanism of toxicity, thorough knowledge of the toxicoki...
Gespeichert in:
| Veröffentlicht in: | Regulatory toxicology and pharmacology 2007-12, Vol.49 (3), p.217-229 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 229 |
|---|---|
| container_issue | 3 |
| container_start_page | 217 |
| container_title | Regulatory toxicology and pharmacology |
| container_volume | 49 |
| creator | Hagens, Werner I. Oomen, Agnes G. de Jong, Wim H. Cassee, Flemming R. Sips, Adriënne J.A.M. |
| description | Nowadays the development and applications of nanotechnology are of major importance in both industrial and consumer areas. However, the knowledge on human exposure and possible toxicity of nanotechnology products is limited. To understand the mechanism of toxicity, thorough knowledge of the toxicokinetic properties of nanoparticles is warranted. There is a need for information on the absorption, distribution, metabolism and excretion (ADME) of nanoparticles and validated detection methods of these man-made nanoparticles. Determination of the ADME properties of nanoparticles requires specialised detection methods in different biological matrices (e.g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (detection, dose, ADME processes) are identified. |
| doi_str_mv | 10.1016/j.yrtph.2007.07.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20425399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S027323000700102X</els_id><sourcerecordid>20425399</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-a650bb8a4cbb8c50ea0c92026668fb1ae9c34f603d1f176cba7d5525befe76f63</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMobn78AkFyJXrReZKuaXshIsMvGHgz8TKk6SnLPpqapI79e9tt4J1wOCEvT96T8xJyxWDEgIn7xWjrQjMfcYB01BeIIzJkkIsIeJ4ckyHwNI54DDAgZ94vAIBnWXpKBizNRJaLeEhmX3MVaGnpBultjVjSYO_osrYbqgrbBhrmSJemxmA0bZxt0AWDntqK1qq2jequetUJpt6hhS23jxfkpFIrj5eH85x8vjzPJm_R9OP1ffI0jXQC4xApkUBRZGqsu95JqEDnHLgQIqsKpjDX8bgSEJesYqnQhUrLJOFJgRWmohLxObnZ-3Yf-27RB7k2XuNqpWq0rZccxjyJ87wD4z2onfXeYSUbZ9bKbSUD2YcpF3IXpuzDlH1Bb399sG-LNZZ_bw7pdcDDHsBuyR-DTnptsNZYGoc6yNKafwf8Am1chzU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20425399</pqid></control><display><type>article</type><title>What do we (need to) know about the kinetic properties of nanoparticles in the body?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hagens, Werner I. ; Oomen, Agnes G. ; de Jong, Wim H. ; Cassee, Flemming R. ; Sips, Adriënne J.A.M.</creator><creatorcontrib>Hagens, Werner I. ; Oomen, Agnes G. ; de Jong, Wim H. ; Cassee, Flemming R. ; Sips, Adriënne J.A.M.</creatorcontrib><description>Nowadays the development and applications of nanotechnology are of major importance in both industrial and consumer areas. However, the knowledge on human exposure and possible toxicity of nanotechnology products is limited. To understand the mechanism of toxicity, thorough knowledge of the toxicokinetic properties of nanoparticles is warranted. There is a need for information on the absorption, distribution, metabolism and excretion (ADME) of nanoparticles and validated detection methods of these man-made nanoparticles. Determination of the ADME properties of nanoparticles requires specialised detection methods in different biological matrices (e.g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (detection, dose, ADME processes) are identified.</description><identifier>ISSN: 0273-2300</identifier><identifier>EISSN: 1096-0295</identifier><identifier>DOI: 10.1016/j.yrtph.2007.07.006</identifier><identifier>PMID: 17868963</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Absorption ; ADME ; Animals ; Detection ; Distribution ; Excretion ; Humans ; Kinetics ; Metabolism ; Models, Biological ; Nanoparticles ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Particle Size ; Pharmacokinetics</subject><ispartof>Regulatory toxicology and pharmacology, 2007-12, Vol.49 (3), p.217-229</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-a650bb8a4cbb8c50ea0c92026668fb1ae9c34f603d1f176cba7d5525befe76f63</citedby><cites>FETCH-LOGICAL-c504t-a650bb8a4cbb8c50ea0c92026668fb1ae9c34f603d1f176cba7d5525befe76f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S027323000700102X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17868963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagens, Werner I.</creatorcontrib><creatorcontrib>Oomen, Agnes G.</creatorcontrib><creatorcontrib>de Jong, Wim H.</creatorcontrib><creatorcontrib>Cassee, Flemming R.</creatorcontrib><creatorcontrib>Sips, Adriënne J.A.M.</creatorcontrib><title>What do we (need to) know about the kinetic properties of nanoparticles in the body?</title><title>Regulatory toxicology and pharmacology</title><addtitle>Regul Toxicol Pharmacol</addtitle><description>Nowadays the development and applications of nanotechnology are of major importance in both industrial and consumer areas. However, the knowledge on human exposure and possible toxicity of nanotechnology products is limited. To understand the mechanism of toxicity, thorough knowledge of the toxicokinetic properties of nanoparticles is warranted. There is a need for information on the absorption, distribution, metabolism and excretion (ADME) of nanoparticles and validated detection methods of these man-made nanoparticles. Determination of the ADME properties of nanoparticles requires specialised detection methods in different biological matrices (e.g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (detection, dose, ADME processes) are identified.</description><subject>Absorption</subject><subject>ADME</subject><subject>Animals</subject><subject>Detection</subject><subject>Distribution</subject><subject>Excretion</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Metabolism</subject><subject>Models, Biological</subject><subject>Nanoparticles</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Particle Size</subject><subject>Pharmacokinetics</subject><issn>0273-2300</issn><issn>1096-0295</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobn78AkFyJXrReZKuaXshIsMvGHgz8TKk6SnLPpqapI79e9tt4J1wOCEvT96T8xJyxWDEgIn7xWjrQjMfcYB01BeIIzJkkIsIeJ4ckyHwNI54DDAgZ94vAIBnWXpKBizNRJaLeEhmX3MVaGnpBultjVjSYO_osrYbqgrbBhrmSJemxmA0bZxt0AWDntqK1qq2jequetUJpt6hhS23jxfkpFIrj5eH85x8vjzPJm_R9OP1ffI0jXQC4xApkUBRZGqsu95JqEDnHLgQIqsKpjDX8bgSEJesYqnQhUrLJOFJgRWmohLxObnZ-3Yf-27RB7k2XuNqpWq0rZccxjyJ87wD4z2onfXeYSUbZ9bKbSUD2YcpF3IXpuzDlH1Bb399sG-LNZZ_bw7pdcDDHsBuyR-DTnptsNZYGoc6yNKafwf8Am1chzU</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Hagens, Werner I.</creator><creator>Oomen, Agnes G.</creator><creator>de Jong, Wim H.</creator><creator>Cassee, Flemming R.</creator><creator>Sips, Adriënne J.A.M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20071201</creationdate><title>What do we (need to) know about the kinetic properties of nanoparticles in the body?</title><author>Hagens, Werner I. ; Oomen, Agnes G. ; de Jong, Wim H. ; Cassee, Flemming R. ; Sips, Adriënne J.A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-a650bb8a4cbb8c50ea0c92026668fb1ae9c34f603d1f176cba7d5525befe76f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Absorption</topic><topic>ADME</topic><topic>Animals</topic><topic>Detection</topic><topic>Distribution</topic><topic>Excretion</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Metabolism</topic><topic>Models, Biological</topic><topic>Nanoparticles</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Particle Size</topic><topic>Pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hagens, Werner I.</creatorcontrib><creatorcontrib>Oomen, Agnes G.</creatorcontrib><creatorcontrib>de Jong, Wim H.</creatorcontrib><creatorcontrib>Cassee, Flemming R.</creatorcontrib><creatorcontrib>Sips, Adriënne J.A.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Regulatory toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagens, Werner I.</au><au>Oomen, Agnes G.</au><au>de Jong, Wim H.</au><au>Cassee, Flemming R.</au><au>Sips, Adriënne J.A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>What do we (need to) know about the kinetic properties of nanoparticles in the body?</atitle><jtitle>Regulatory toxicology and pharmacology</jtitle><addtitle>Regul Toxicol Pharmacol</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>49</volume><issue>3</issue><spage>217</spage><epage>229</epage><pages>217-229</pages><issn>0273-2300</issn><eissn>1096-0295</eissn><abstract>Nowadays the development and applications of nanotechnology are of major importance in both industrial and consumer areas. However, the knowledge on human exposure and possible toxicity of nanotechnology products is limited. To understand the mechanism of toxicity, thorough knowledge of the toxicokinetic properties of nanoparticles is warranted. There is a need for information on the absorption, distribution, metabolism and excretion (ADME) of nanoparticles and validated detection methods of these man-made nanoparticles. Determination of the ADME properties of nanoparticles requires specialised detection methods in different biological matrices (e.g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (detection, dose, ADME processes) are identified.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>17868963</pmid><doi>10.1016/j.yrtph.2007.07.006</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0273-2300 |
| ispartof | Regulatory toxicology and pharmacology, 2007-12, Vol.49 (3), p.217-229 |
| issn | 0273-2300 1096-0295 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20425399 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Absorption ADME Animals Detection Distribution Excretion Humans Kinetics Metabolism Models, Biological Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Particle Size Pharmacokinetics |
| title | What do we (need to) know about the kinetic properties of nanoparticles in the body? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T12%3A58%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=What%20do%20we%20(need%20to)%20know%20about%20the%20kinetic%20properties%20of%20nanoparticles%20in%20the%20body?&rft.jtitle=Regulatory%20toxicology%20and%20pharmacology&rft.au=Hagens,%20Werner%20I.&rft.date=2007-12-01&rft.volume=49&rft.issue=3&rft.spage=217&rft.epage=229&rft.pages=217-229&rft.issn=0273-2300&rft.eissn=1096-0295&rft_id=info:doi/10.1016/j.yrtph.2007.07.006&rft_dat=%3Cproquest_cross%3E20425399%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20425399&rft_id=info:pmid/17868963&rft_els_id=S027323000700102X&rfr_iscdi=true |