Dynamics of the action of dFOXO on adult mortality in Drosophila

Summary The insulin/insulin growth factor (IGF)‐like signaling (IIS) pathway has a conserved role in regulating lifespan in Caenorhabditis elegans, Drosophila and mice. Extension of lifespan by reduced IIS has been shown in C. elegans to require the key IIS target, forkhead box class O (FOXO) transc...

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Veröffentlicht in:	Aging cell 2007-08, Vol.6 (4), p.429-438
Hauptverfasser:	Giannakou, Maria E., Goss, Martin, Jacobson, Jake, Vinti, Giovanna, Leevers, Sally J., Partridge, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - physiology Animals Caenorhabditis elegans Drosophila Drosophila melanogaster - metabolism Drosophila melanogaster - physiology Drosophila Proteins - metabolism Female Forkhead Transcription Factors - metabolism Gene Expression Regulation Insulin-Like Growth Factor I - metabolism insulin/IGF signalling life span Longevity - physiology Mifepristone - adverse effects mortality Signal Transduction
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