Evaluation of pyrosequencing for extensive drug resistance-defining anti-tuberculosis drugs for use in public healthcare

MGIT 960 drug susceptibility testing (DST) for Mycobacterium tuberculosis was compared for performance and speed with pyrosequencing (PSQ). Pulmonary samples (n = 100), from GeneXpert/MTB/Rifampicin-resistant patients receiving second-line treatment for 1–3 months, were subjected to DST and PSQ for...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2018-05, Vol.110, p.86-90
Hauptverfasser:	Nambiar, Remya, Shah, Daksha, Ajbani, Kanchan, Kazi, Mubin, Sadani, Meeta, Shetty, Anjali, Keskar, Padmaja, Kamble, Sanjeev, van Belkum, Alex, Rodrigues, Camilla
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin Antitubercular Agents - pharmacology Bacteria Capreomycin DNA, Bacterial - genetics Drug resistance Drug Resistance, Multiple, Bacterial - genetics Drugs Extensively Drug-Resistant Tuberculosis - microbiology Feasibility Studies Genotype Genotypes Health care High-Throughput Nucleotide Sequencing - methods Humans Isoniazid Kanamycin Microbial Sensitivity Tests - methods Moxifloxacin Mutation Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Ofloxacin Phenotype Phenotypic DST Post-production processing Public Health Pyrosequencing Resistance Rifampin RpoB protein Sequence Analysis, DNA - methods Tuberculosis
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