Transition metal-free one-pot double C-H functionalization of quinolines with disubstituted electron-deficient acetylenes

Transition metal-free one-pot reaction of quinolines with acylarylacetylenes and water proceeds in the presence of KOH (55-60 °C, MeCN, 48 h) to afford 2-aryl-3-acylquinolines in up to 66% yield. Here, a formal replacement of the acetylene moiety by the aryl and acyl substituents in the quinoline sc...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018, Vol.54 (46), p.5863-5866
Hauptverfasser:	Trofimov, B A, Belyaeva, K V, Nikitina, L P, Mal'kina, A G, Afonin, A V, Ushakov, I A, Vashchenko, A V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylene Aromatic compounds Functional groups Organic compounds Quinoline
Online-Zugang:	Volltext
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