Procalcitonin and C-reactive protein as markers of infection in systemic lupus erythematosus: the controversy continues
Objective The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients. Patients and methods Sixty-nine SLE patients with symptoms and signs of infection proved by culture an...
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| Veröffentlicht in: | Lupus 2019-10, Vol.28 (11), p.1329-1336 |
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| creator | El-serougy, E Zayed, H S Ibrahim, N M Maged, L A |
| description | Objective
The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients.
Patients and methods
Sixty-nine SLE patients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLE patients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay.
Results
SLE patients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104.5 (25.5–100.9) and 10.3 (5.4–23.1) mg/l, respectively), p |
| doi_str_mv | 10.1177/0961203318777101 |
| format | Article |
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The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients.
Patients and methods
Sixty-nine SLE patients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLE patients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay.
Results
SLE patients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104.5 (25.5–100.9) and 10.3 (5.4–23.1) mg/l, respectively), p<0.001).
Conclusion
Serum PCT could not differentiate SLE patients with or without bacterial infection in this study, while the utility of CRP as a marker of infection has been confirmed.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203318777101</identifier><identifier>PMID: 29779437</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Antibiotics ; Bacterial Infections - blood ; Bacterial Infections - diagnosis ; Biomarkers - blood ; C-reactive protein ; C-Reactive Protein - analysis ; Enzyme-linked immunosorbent assay ; Female ; Humans ; Infections ; Lupus ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - complications ; Male ; Middle Aged ; Procalcitonin ; Procalcitonin - blood ; Prospective Studies ; Systemic lupus erythematosus ; Young Adult</subject><ispartof>Lupus, 2019-10, Vol.28 (11), p.1329-1336</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-3005072d037705b0d086e5288ccbe1ebd56cd5a0f6ccadf41d0b2a2294ca26a73</citedby><cites>FETCH-LOGICAL-c365t-3005072d037705b0d086e5288ccbe1ebd56cd5a0f6ccadf41d0b2a2294ca26a73</cites><orcidid>0000-0002-1019-2742 ; 0000-0001-9755-2677</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203318777101$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203318777101$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29779437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-serougy, E</creatorcontrib><creatorcontrib>Zayed, H S</creatorcontrib><creatorcontrib>Ibrahim, N M</creatorcontrib><creatorcontrib>Maged, L A</creatorcontrib><title>Procalcitonin and C-reactive protein as markers of infection in systemic lupus erythematosus: the controversy continues</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Objective
The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients.
Patients and methods
Sixty-nine SLE patients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLE patients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay.
Results
SLE patients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104.5 (25.5–100.9) and 10.3 (5.4–23.1) mg/l, respectively), p<0.001).
Conclusion
Serum PCT could not differentiate SLE patients with or without bacterial infection in this study, while the utility of CRP as a marker of infection has been confirmed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibiotics</subject><subject>Bacterial Infections - blood</subject><subject>Bacterial Infections - diagnosis</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Humans</subject><subject>Infections</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Procalcitonin</subject><subject>Procalcitonin - blood</subject><subject>Prospective Studies</subject><subject>Systemic lupus erythematosus</subject><subject>Young Adult</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1LxDAQDaLounr3JAEvXqqTpG1ab7L4BYIe9FzSdKrVNlmTVNl_b9b1AxY85THz3puZPEIOGJwwJuUplDnjIAQrpJQM2AaZsFTKJNb5Jpks28myv0N2vX8BAMHKfJvs8FLKMhVyQj7undWq112wpjNUmYbOEodKh-4d6dzZgMuyp4Nyr-g8tS3tTIuxb01E1C98wKHTtB_no6foFuEZBxWsH_0ZjZhqa4Kz71G8-MKdGdHvka1W9R73v98peby8eJhdJ7d3Vzez89tEizwLiQDIQPIGhJSQ1dBAkWPGi0LrGhnWTZbrJlPQ5lqrpk1ZAzVXnJepVjxXUkzJ8co3nvIW54Zq6LzGvlcG7egrDinnQhRFGalHa9QXOzoTt6t43KPksswhsmDF0s5677Ct5q6Ln7OoGFTLUKr1UKLk8Nt4rAdsfgU_KURCsiJ49YR_U_81_AQaopW2</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>El-serougy, E</creator><creator>Zayed, H S</creator><creator>Ibrahim, N M</creator><creator>Maged, L A</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1019-2742</orcidid><orcidid>https://orcid.org/0000-0001-9755-2677</orcidid></search><sort><creationdate>20191001</creationdate><title>Procalcitonin and C-reactive protein as markers of infection in systemic lupus erythematosus: the controversy continues</title><author>El-serougy, E ; Zayed, H S ; Ibrahim, N M ; Maged, L A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-3005072d037705b0d086e5288ccbe1ebd56cd5a0f6ccadf41d0b2a2294ca26a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibiotics</topic><topic>Bacterial Infections - blood</topic><topic>Bacterial Infections - diagnosis</topic><topic>Biomarkers - blood</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Humans</topic><topic>Infections</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Procalcitonin</topic><topic>Procalcitonin - blood</topic><topic>Prospective Studies</topic><topic>Systemic lupus erythematosus</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-serougy, E</creatorcontrib><creatorcontrib>Zayed, H S</creatorcontrib><creatorcontrib>Ibrahim, N M</creatorcontrib><creatorcontrib>Maged, L A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-serougy, E</au><au>Zayed, H S</au><au>Ibrahim, N M</au><au>Maged, L A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Procalcitonin and C-reactive protein as markers of infection in systemic lupus erythematosus: the controversy continues</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>28</volume><issue>11</issue><spage>1329</spage><epage>1336</epage><pages>1329-1336</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Objective
The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients.
Patients and methods
Sixty-nine SLE patients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLE patients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay.
Results
SLE patients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104.5 (25.5–100.9) and 10.3 (5.4–23.1) mg/l, respectively), p<0.001).
Conclusion
Serum PCT could not differentiate SLE patients with or without bacterial infection in this study, while the utility of CRP as a marker of infection has been confirmed.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29779437</pmid><doi>10.1177/0961203318777101</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1019-2742</orcidid><orcidid>https://orcid.org/0000-0001-9755-2677</orcidid></addata></record> |
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| language | eng |
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| subjects | Adolescent Adult Antibiotics Bacterial Infections - blood Bacterial Infections - diagnosis Biomarkers - blood C-reactive protein C-Reactive Protein - analysis Enzyme-linked immunosorbent assay Female Humans Infections Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - complications Male Middle Aged Procalcitonin Procalcitonin - blood Prospective Studies Systemic lupus erythematosus Young Adult |
| title | Procalcitonin and C-reactive protein as markers of infection in systemic lupus erythematosus: the controversy continues |
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