MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells
Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA e...
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Veröffentlicht in: | Doklady. Biochemistry and biophysics 2018-03, Vol.479 (1), p.101-104 |
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container_title | Doklady. Biochemistry and biophysics |
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creator | Tarasov, V. A. Tyutyakina, M. G. Makhotkin, M. A. Shin, E. F. Naboka, A. V. Mashkarina, A. N. Chebotarev, D. A. Cherkasova, E. N. Kogan, M. I. Chibichyan, M. B. Matishov, D. G. |
description | Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor (
IGF1R
) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells. |
doi_str_mv | 10.1134/S1607672918020138 |
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IGF1R
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IGF1R
) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells.</description><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Gene expression</subject><subject>Insulin</subject><subject>Insulin-like growth factor I receptors</subject><subject>Life Sciences</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Molecular Biology</subject><subject>Prostate cancer</subject><issn>1607-6729</issn><issn>1608-3091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctOwzAQRS0EoqXwAWyQJTZsAmM7jZNlVdqCxEstrCMnmVSpWrvYCY-_x6FQJBArj2bO3LnyJeSYwTljIryYsQhkJHnCYuDARLxDur4VBwIStvtZy6Cdd8iBcwvwEBf9fdLhiZQJg7hLXm-r3Jrp3SC4xDXqAnVNpzhvlqqujKampNeTMZvSCWqko7e1RefaQaXplbErozGYoXZVXb0gVbrYdqfoKlcrL_dgjS9qpEOlc7R0iMulOyR7pVo6PPp6e-RpPHocXgU395Pr4eAmyAUP64BHjPchzwqeZUryMozipC_iWOQgJBSqzPKMKwgBw6SUouSsCCUkkYASFSaF6JGzje7amucGXZ2uKpd7B0qjaVzKIeRcCBmCR09_oQvTWO3dtZT3IaNIeoptKP9tzlks07WtVsq-pwzSNpX0Typ-5-RLuclWWGw3vmPwAN8Azo_0HO3P6f9VPwB21pWh</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Tarasov, V. 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Biochemistry and biophysics</jtitle><stitle>Dokl Biochem Biophys</stitle><addtitle>Dokl Biochem Biophys</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>479</volume><issue>1</issue><spage>101</spage><epage>104</epage><pages>101-104</pages><issn>1607-6729</issn><eissn>1608-3091</eissn><abstract>Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor (
IGF1R
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subjects | Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Gene expression Insulin Insulin-like growth factor I receptors Life Sciences MicroRNAs miRNA Molecular Biology Prostate cancer |
title | MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells |
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