MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells

Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA e...

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Veröffentlicht in:Doklady. Biochemistry and biophysics 2018-03, Vol.479 (1), p.101-104
Hauptverfasser: Tarasov, V. A., Tyutyakina, M. G., Makhotkin, M. A., Shin, E. F., Naboka, A. V., Mashkarina, A. N., Chebotarev, D. A., Cherkasova, E. N., Kogan, M. I., Chibichyan, M. B., Matishov, D. G.
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container_end_page 104
container_issue 1
container_start_page 101
container_title Doklady. Biochemistry and biophysics
container_volume 479
creator Tarasov, V. A.
Tyutyakina, M. G.
Makhotkin, M. A.
Shin, E. F.
Naboka, A. V.
Mashkarina, A. N.
Chebotarev, D. A.
Cherkasova, E. N.
Kogan, M. I.
Chibichyan, M. B.
Matishov, D. G.
description Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor ( IGF1R ) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells.
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source SpringerNature Journals
subjects Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Gene expression
Insulin
Insulin-like growth factor I receptors
Life Sciences
MicroRNAs
miRNA
Molecular Biology
Prostate cancer
title MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells
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