Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy
[Display omitted] The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranost...
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creator | Zhang, Linhua Qin, Yu Zhang, Zhiming Fan, Fan Huang, Chenlu Lu, Li Wang, Hai Jin, Xu Zhao, Hanxue Kong, Deling Wang, Chun Sun, Hongfan Leng, Xigang Zhu, Dunwan |
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The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs exhibited nano-sized structure (∼100 nm) with good monodispersity, high encapsulation efficiency of both ICG and DOX, triggered DOX release in response to acid pH and reduction environment, and excellent temperature conversion with laser irradiation. In vitro cellular uptake study indicated FA Co-PMs achieved significant targeting to BEL-7404 cells via folate receptor-mediated endocytosis, and laser-induced hyperthermia further enhanced drug accumulation into cancer cells. In vivo biodistribution study indicated that FA Co-PMs prolonged drug circulation and enhanced drug accumulation into the tumor via EPR effect and FA targeting. Furthermore, the ICG-based photo-triggered hyperthermia combined with DOX-based chemotherapy synergistically induced the BEL-7404 cell death and apoptosis, and efficiently suppressed the BEL-7404 xenografted tumor growth while significantly reduced systemic toxicity in vivo. Therefore, the designed dual-responsive Co-PMs were promising theranostic nanocarriers for versatile antitumor drug delivery and imaging-guided cancer chemo-photothermal combination therapy.
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed novel pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs triggered DOX release in response to acid pH and reduction environment and exhibited excellent temperature conversion with laser irradiation. The results indicated FA Co-PMs achieved significant targeting to BEL-7404 cells in vitro and efficiently suppressed the BEL-7404 xenografted tumor growth while significantly reduced systemic toxicity in vivo. Therefore, the designed dual-responsive Co-PMs displayed great potential in imaging-guided cancer chemo-photothermal combination therapy as |
doi_str_mv | 10.1016/j.actbio.2018.05.026 |
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The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs exhibited nano-sized structure (∼100 nm) with good monodispersity, high encapsulation efficiency of both ICG and DOX, triggered DOX release in response to acid pH and reduction environment, and excellent temperature conversion with laser irradiation. In vitro cellular uptake study indicated FA Co-PMs achieved significant targeting to BEL-7404 cells via folate receptor-mediated endocytosis, and laser-induced hyperthermia further enhanced drug accumulation into cancer cells. In vivo biodistribution study indicated that FA Co-PMs prolonged drug circulation and enhanced drug accumulation into the tumor via EPR effect and FA targeting. Furthermore, the ICG-based photo-triggered hyperthermia combined with DOX-based chemotherapy synergistically induced the BEL-7404 cell death and apoptosis, and efficiently suppressed the BEL-7404 xenografted tumor growth while significantly reduced systemic toxicity in vivo. Therefore, the designed dual-responsive Co-PMs were promising theranostic nanocarriers for versatile antitumor drug delivery and imaging-guided cancer chemo-photothermal combination therapy.
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed novel pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs triggered DOX release in response to acid pH and reduction environment and exhibited excellent temperature conversion with laser irradiation. The results indicated FA Co-PMs achieved significant targeting to BEL-7404 cells in vitro and efficiently suppressed the BEL-7404 xenografted tumor growth while significantly reduced systemic toxicity in vivo. Therefore, the designed dual-responsive Co-PMs displayed great potential in imaging-guided cancer chemo-photothermal combination therapy as theranostic nanocarriers.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2018.05.026</identifier><identifier>PMID: 29777957</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Accumulation ; Animals ; Apoptosis ; Biocompatibility ; Cancer ; Cell death ; Cell Line, Tumor ; Cells ; Chemo-photothermal therapy ; Chemotherapy ; Delayed-Action Preparations - chemistry ; Delayed-Action Preparations - pharmacokinetics ; Delayed-Action Preparations - pharmacology ; Doxorubicin ; Doxorubicin - chemistry ; Doxorubicin - pharmacokinetics ; Doxorubicin - pharmacology ; Drug delivery ; Drug delivery systems ; Dual-responsive ; Encapsulation ; Endocytosis ; Female ; Folic acid ; Humans ; Hybrid polymeric micelles ; Hyperthermia ; Hyperthermia, Induced ; In vivo methods and tests ; Indocyanine green ; Indocyanine Green - chemistry ; Indocyanine Green - pharmacokinetics ; Indocyanine Green - pharmacology ; Irradiation ; Liver Neoplasms, Experimental - diagnostic imaging ; Liver Neoplasms, Experimental - metabolism ; Liver Neoplasms, Experimental - therapy ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Micelles ; Molecules ; Optical Imaging ; pH effects ; Phototherapy ; Photothermal conversion ; Polymers ; Reduction ; Toxicity ; Tumors ; Xenograft Model Antitumor Assays ; Xenografts</subject><ispartof>Acta biomaterialia, 2018-07, Vol.75, p.371-385</ispartof><rights>2018 Acta Materialia Inc.</rights><rights>Copyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Jul 15, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-bafc3e0028db9c8c54fe833e2601ccf6bfd601b3d62fca33efab7a8b9896276a3</citedby><cites>FETCH-LOGICAL-c390t-bafc3e0028db9c8c54fe833e2601ccf6bfd601b3d62fca33efab7a8b9896276a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706118302952$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29777957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Linhua</creatorcontrib><creatorcontrib>Qin, Yu</creatorcontrib><creatorcontrib>Zhang, Zhiming</creatorcontrib><creatorcontrib>Fan, Fan</creatorcontrib><creatorcontrib>Huang, Chenlu</creatorcontrib><creatorcontrib>Lu, Li</creatorcontrib><creatorcontrib>Wang, Hai</creatorcontrib><creatorcontrib>Jin, Xu</creatorcontrib><creatorcontrib>Zhao, Hanxue</creatorcontrib><creatorcontrib>Kong, Deling</creatorcontrib><creatorcontrib>Wang, Chun</creatorcontrib><creatorcontrib>Sun, Hongfan</creatorcontrib><creatorcontrib>Leng, Xigang</creatorcontrib><creatorcontrib>Zhu, Dunwan</creatorcontrib><title>Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs exhibited nano-sized structure (∼100 nm) with good monodispersity, high encapsulation efficiency of both ICG and DOX, triggered DOX release in response to acid pH and reduction environment, and excellent temperature conversion with laser irradiation. In vitro cellular uptake study indicated FA Co-PMs achieved significant targeting to BEL-7404 cells via folate receptor-mediated endocytosis, and laser-induced hyperthermia further enhanced drug accumulation into cancer cells. In vivo biodistribution study indicated that FA Co-PMs prolonged drug circulation and enhanced drug accumulation into the tumor via EPR effect and FA targeting. Furthermore, the ICG-based photo-triggered hyperthermia combined with DOX-based chemotherapy synergistically induced the BEL-7404 cell death and apoptosis, and efficiently suppressed the BEL-7404 xenografted tumor growth while significantly reduced systemic toxicity in vivo. Therefore, the designed dual-responsive Co-PMs were promising theranostic nanocarriers for versatile antitumor drug delivery and imaging-guided cancer chemo-photothermal combination therapy.
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed novel pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs triggered DOX release in response to acid pH and reduction environment and exhibited excellent temperature conversion with laser irradiation. The results indicated FA Co-PMs achieved significant targeting to BEL-7404 cells in vitro and efficiently suppressed the BEL-7404 xenografted tumor growth while significantly reduced systemic toxicity in vivo. Therefore, the designed dual-responsive Co-PMs displayed great potential in imaging-guided cancer chemo-photothermal combination therapy as theranostic nanocarriers.</description><subject>Accumulation</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biocompatibility</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Cells</subject><subject>Chemo-photothermal therapy</subject><subject>Chemotherapy</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Delayed-Action Preparations - pharmacokinetics</subject><subject>Delayed-Action Preparations - pharmacology</subject><subject>Doxorubicin</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - pharmacokinetics</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Dual-responsive</subject><subject>Encapsulation</subject><subject>Endocytosis</subject><subject>Female</subject><subject>Folic acid</subject><subject>Humans</subject><subject>Hybrid polymeric micelles</subject><subject>Hyperthermia</subject><subject>Hyperthermia, Induced</subject><subject>In vivo methods and tests</subject><subject>Indocyanine green</subject><subject>Indocyanine Green - chemistry</subject><subject>Indocyanine Green - pharmacokinetics</subject><subject>Indocyanine Green - pharmacology</subject><subject>Irradiation</subject><subject>Liver Neoplasms, Experimental - diagnostic imaging</subject><subject>Liver Neoplasms, Experimental - metabolism</subject><subject>Liver Neoplasms, Experimental - therapy</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Micelles</subject><subject>Molecules</subject><subject>Optical Imaging</subject><subject>pH effects</subject><subject>Phototherapy</subject><subject>Photothermal conversion</subject><subject>Polymers</subject><subject>Reduction</subject><subject>Toxicity</subject><subject>Tumors</subject><subject>Xenograft Model Antitumor Assays</subject><subject>Xenografts</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1TAQhqMK1Bu8AUKR2LBJ6ktiOxskVFqKVIkNrC1fxhxHSRxsp9J5exydlgULVjOa-eaf0fxV9Q6jFiPMbsZWmax9aAnCokV9iwg7qy6x4KLhPROvSs470nDE8EV1ldKIEBWYiPPqggyc86Hnl9X4ZVNTvT7cRLCbyT4sTYS0hiX5J6gPRx29rdcwHWeI3tSzNzBNkGoXYp1V_AUZbG0OMIdmPYQc8gHiXBRNmLVf1C5Y7zW1Ht9Ur52aErx9jtfVz_u7H7cPzeP3r99uPz82hg4oN1o5QwEhIqwejDB950BQCoQhbIxj2tmSaWoZcUaVhlOaK6EHMTDCmaLX1ceT7hrD7w1SlrNP-9lqgbAlSVBHCEU97Qr64R90DFtcynWFGjjrGUG0UN2JMjGkFMHJNfpZxaPESO5eyFGevJC7FxL1snhRxt4_i296Bvt36OX5Bfh0AqB848lDlMl4WAxYH8FkaYP__4Y_UNmfGw</recordid><startdate>20180715</startdate><enddate>20180715</enddate><creator>Zhang, Linhua</creator><creator>Qin, Yu</creator><creator>Zhang, Zhiming</creator><creator>Fan, Fan</creator><creator>Huang, Chenlu</creator><creator>Lu, Li</creator><creator>Wang, Hai</creator><creator>Jin, Xu</creator><creator>Zhao, Hanxue</creator><creator>Kong, Deling</creator><creator>Wang, Chun</creator><creator>Sun, Hongfan</creator><creator>Leng, Xigang</creator><creator>Zhu, Dunwan</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20180715</creationdate><title>Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy</title><author>Zhang, Linhua ; Qin, Yu ; Zhang, Zhiming ; Fan, Fan ; Huang, Chenlu ; Lu, Li ; Wang, Hai ; Jin, Xu ; Zhao, Hanxue ; Kong, Deling ; Wang, Chun ; Sun, Hongfan ; Leng, Xigang ; Zhu, Dunwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-bafc3e0028db9c8c54fe833e2601ccf6bfd601b3d62fca33efab7a8b9896276a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Accumulation</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biocompatibility</topic><topic>Cancer</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Cells</topic><topic>Chemo-photothermal therapy</topic><topic>Chemotherapy</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Delayed-Action Preparations - pharmacokinetics</topic><topic>Delayed-Action Preparations - pharmacology</topic><topic>Doxorubicin</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - pharmacokinetics</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Dual-responsive</topic><topic>Encapsulation</topic><topic>Endocytosis</topic><topic>Female</topic><topic>Folic acid</topic><topic>Humans</topic><topic>Hybrid polymeric micelles</topic><topic>Hyperthermia</topic><topic>Hyperthermia, Induced</topic><topic>In vivo methods and tests</topic><topic>Indocyanine green</topic><topic>Indocyanine Green - chemistry</topic><topic>Indocyanine Green - pharmacokinetics</topic><topic>Indocyanine Green - pharmacology</topic><topic>Irradiation</topic><topic>Liver Neoplasms, Experimental - diagnostic imaging</topic><topic>Liver Neoplasms, Experimental - metabolism</topic><topic>Liver Neoplasms, Experimental - therapy</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Micelles</topic><topic>Molecules</topic><topic>Optical Imaging</topic><topic>pH effects</topic><topic>Phototherapy</topic><topic>Photothermal conversion</topic><topic>Polymers</topic><topic>Reduction</topic><topic>Toxicity</topic><topic>Tumors</topic><topic>Xenograft Model Antitumor Assays</topic><topic>Xenografts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Linhua</creatorcontrib><creatorcontrib>Qin, Yu</creatorcontrib><creatorcontrib>Zhang, Zhiming</creatorcontrib><creatorcontrib>Fan, Fan</creatorcontrib><creatorcontrib>Huang, Chenlu</creatorcontrib><creatorcontrib>Lu, Li</creatorcontrib><creatorcontrib>Wang, Hai</creatorcontrib><creatorcontrib>Jin, Xu</creatorcontrib><creatorcontrib>Zhao, Hanxue</creatorcontrib><creatorcontrib>Kong, Deling</creatorcontrib><creatorcontrib>Wang, Chun</creatorcontrib><creatorcontrib>Sun, Hongfan</creatorcontrib><creatorcontrib>Leng, Xigang</creatorcontrib><creatorcontrib>Zhu, Dunwan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Linhua</au><au>Qin, Yu</au><au>Zhang, Zhiming</au><au>Fan, Fan</au><au>Huang, Chenlu</au><au>Lu, Li</au><au>Wang, Hai</au><au>Jin, Xu</au><au>Zhao, Hanxue</au><au>Kong, Deling</au><au>Wang, Chun</au><au>Sun, Hongfan</au><au>Leng, Xigang</au><au>Zhu, Dunwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2018-07-15</date><risdate>2018</risdate><volume>75</volume><spage>371</spage><epage>385</epage><pages>371-385</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs exhibited nano-sized structure (∼100 nm) with good monodispersity, high encapsulation efficiency of both ICG and DOX, triggered DOX release in response to acid pH and reduction environment, and excellent temperature conversion with laser irradiation. In vitro cellular uptake study indicated FA Co-PMs achieved significant targeting to BEL-7404 cells via folate receptor-mediated endocytosis, and laser-induced hyperthermia further enhanced drug accumulation into cancer cells. In vivo biodistribution study indicated that FA Co-PMs prolonged drug circulation and enhanced drug accumulation into the tumor via EPR effect and FA targeting. Furthermore, the ICG-based photo-triggered hyperthermia combined with DOX-based chemotherapy synergistically induced the BEL-7404 cell death and apoptosis, and efficiently suppressed the BEL-7404 xenografted tumor growth while significantly reduced systemic toxicity in vivo. Therefore, the designed dual-responsive Co-PMs were promising theranostic nanocarriers for versatile antitumor drug delivery and imaging-guided cancer chemo-photothermal combination therapy.
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed novel pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs triggered DOX release in response to acid pH and reduction environment and exhibited excellent temperature conversion with laser irradiation. The results indicated FA Co-PMs achieved significant targeting to BEL-7404 cells in vitro and efficiently suppressed the BEL-7404 xenografted tumor growth while significantly reduced systemic toxicity in vivo. Therefore, the designed dual-responsive Co-PMs displayed great potential in imaging-guided cancer chemo-photothermal combination therapy as theranostic nanocarriers.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29777957</pmid><doi>10.1016/j.actbio.2018.05.026</doi><tpages>15</tpages></addata></record> |
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subjects | Accumulation Animals Apoptosis Biocompatibility Cancer Cell death Cell Line, Tumor Cells Chemo-photothermal therapy Chemotherapy Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug delivery Drug delivery systems Dual-responsive Encapsulation Endocytosis Female Folic acid Humans Hybrid polymeric micelles Hyperthermia Hyperthermia, Induced In vivo methods and tests Indocyanine green Indocyanine Green - chemistry Indocyanine Green - pharmacokinetics Indocyanine Green - pharmacology Irradiation Liver Neoplasms, Experimental - diagnostic imaging Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - therapy Mice Mice, Inbred BALB C Mice, Nude Micelles Molecules Optical Imaging pH effects Phototherapy Photothermal conversion Polymers Reduction Toxicity Tumors Xenograft Model Antitumor Assays Xenografts |
title | Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy |
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