The effect of variable cigarette consumption on the interaction with clozapine and olanzapine

Cigarette smoking has been shown in several studies to induce the metabolism of the cytochrome P4501A2 (CYP1A2) substrates clozapine and olanzapine. The aim of the present study was to investigate the dose-dependent effect of cigarette smoking on serum concentrations of these drugs in a naturalistic...

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Veröffentlicht in:	European journal of clinical pharmacology 2006-12, Vol.62 (12), p.1049-1053
Hauptverfasser:	HASLEMO, Tore, EIKESETH, Per Haakon, TANUM, Lars, MOLDEN, Espen, REFSUM, Helge
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antipsychotic Agents - blood Antipsychotic Agents - pharmacokinetics Antipsychotic Agents - therapeutic use Benzodiazepines - blood Benzodiazepines - pharmacokinetics Benzodiazepines - therapeutic use Biological and medical sciences Chromatography, High Pressure Liquid Cigarettes Clozapine - blood Clozapine - pharmacokinetics Clozapine - therapeutic use Cytochrome P-450 CYP1A2 - metabolism Dose-Response Relationship, Drug Drug dosages Drug Interactions Drug Monitoring - methods Drug therapy Female General aspects Humans Inpatients - statistics & numerical data Male Mass Spectrometry Medical sciences Metabolic Clearance Rate Middle Aged Nursing Homes Pharmacology Pharmacology. Drug treatments Schizophrenia - drug therapy Schizophrenia - metabolism Smoking - blood Tobacco, tobacco smoking Toxicology
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